Pliant Therapeutics — Third Quarter 2026 Earnings Summary

Pliant Therapeutics reported a net loss of $24.4 million for the third quarter of 2026, with research and development expenses remaining flat at $17.9 million despite the termination of its bexotegrast program. The company's lead candidate, PLN-101095, continues to enroll ahead of schedule in the FORTIFY Phase 1b trial for immune checkpoint inhibitor-refractory solid tumors, with interim data expected in 2027. Pliant also announced the appointment of David Raben as Chief Medical Officer and Craig Blanchette as Senior Vice President of Research to lead its RNAi initiatives. The company's proprietary integrin-mediated delivery platform has demonstrated over 75% target gene knockdown in non-human primate studies while avoiding liver exposure, supporting plans to target neuromuscular and cardiac diseases. As of September 30, 2026, Pliant held $142.6 million in cash and short-term investments, which is projected to fund operations through mid-2028.