Spero Therapeutics — Third Quarter 2026 Earnings Summary

Spero Therapeutics announced its third-quarter 2026 financial results, reporting a net loss of $44.3 million and research and development expenses of $38.2 million, which included a $35 million upfront payment for the in-licensing of SP001 from Innovent Biologics. The company secured $105 million in non-recourse financing in July 2026, bringing its cash and cash equivalents to $107.9 million as of September 30, 2026, sufficient to fund operations into the second half of 2029. SP001, a third-generation anti-CD40L antibody, is advancing toward a Phase 2 study in IgG4-related disease scheduled for the second quarter of 2027. Spero has also strengthened its leadership team with new appointments for Chief Medical Officer, Chief Regulatory and Quality Officer, and a new Board member to support its clinical development strategy.