Human Brain Development - Paola Arlotta, Professor, Harvard Stem Cell Institute | AI Podcast Clips

Brain development begins in the embryo with a neural tube that follows a strict temporal and spatial hierarchy to generate neurons before glial cells, driven by both genetic programs and mechanical forces. While in vivo construction ensures high structural fidelity through distributed biological mechanisms, current in vitro organoid models struggle with significant variability due to the lack of an authentic developmental environment. This fundamental building process continues postnatally through extensive myelination and maturation that persists well into adulthood, typically concluding between ages 25 and 30.