Latest Interviews
Showing 691–705 of 809 transcripts.
Clear all filters- Milken Institute35 min
A Conversation with FDA Commissioner Scott Gottlieb
Former FDA Commissioner Scott Gottlieb outlines a multifaceted regulatory strategy addressing the opioid epidemic, tobacco addiction, and the aftermath of Hurricane María on Puerto Rico's critical medical manufacturing sector. He emphasizes adapting regulatory frameworks for emerging technologies like artificial intelligence and digital health tools while prioritizing the prevention of medical misinformation and product shortages. The discussion highlights a shift toward reducing review cycles, de-risking early-stage development, and utilizing post-market surveillance to balance safety with innovation.
- Milken Institute34 min
A Conversation with PepsiCo CEO Indra Nooyi
Indra Nooyi, Michael Milken, Andrew, Mike
PepsiCo CEO Indra Nooyi transformed the beverage and snack giant through "Performance with Purpose," a strategy that integrated social and environmental sustainability into core operations while shifting the revenue portfolio toward healthier product lines. This cultural overhaul was driven by scientific leadership under Chief Scientific Officer Dr. Mahmood Khan and reinforced by tying executive compensation to specific nutritional and environmental goals. Nooyi further extended the company's impact by forging partnerships with healthcare institutions to improve access for underserved veterans and advocating for systemic policy changes to address chronic disease and nutritional equity.
- Milken Institute43 min
Putting Prevention First
Liz Szabo, Kelly Close, William Dietz, Frank Hu, Anne Schuchat, Hugh Waters, Bill Dietz
Recent data reveals that US obesity rates continue to rise across all demographics, with annual prevalence increasing by 1% for decades and severe disparities affecting over half of African American and Hispanic women. These trends drive a $3.4 trillion annual economic burden and sharply increase risks for diabetes, cardiovascular disease, and 13 types of cancer, prompting experts to shift focus from treating established obesity to preventing weight gain in young adults through environmental changes and policy reform.
- Y Combinator29 min
Building a Startup is About Solving a Problem - Avni Patel Thompson of Poppy
Founded by Avni, Poppy is a Seattle-based childcare network designed to recreate a modern village by connecting vetted caregivers with families seeking reliability. After a failed subscription box startup and multiple rejections from Y Combinator, Avni pivoted by leveraging manual "concierge" operations to validate demand, eventually securing over $2 million in seed funding and acceptance into the Winter 2016 cohort. The company now operates on a weekly growth rhythm that prioritizes solving core customer frustrations over product perfection, demonstrating how curiosity and user feedback drove the transition from a personal struggle to a scalable business model.
- Y Combinator27 min
Founders of Science Exchange, Goldbely, and The Flex Company Discuss Fundraising
Kat Manalac, Elizabeth Iorns, Vanessa Torrivilla, Erica Jensen, Elizabeth Lyons
Hosted by Kat, a panel featuring YC alumni founders Elizabeth Lyons, Vanessa Torribilla, and Erica examined fundraising hurdles across diverse sectors, revealing that initial seed rounds consistently register as the most difficult stage. The founders detailed a strategic shift from vision-based narratives to rigorous data preparation for Series A, while offering specific tactics for overcoming gender bias and managing team resources to prevent metric stagnation. Ultimately, the discussion emphasized the necessity of aligning investor outreach with relevant demographics and maintaining founder well-being to sustain long-term growth.
- Y Combinator26 min
Morgan DeBaun on Reaching 20M Millennials - With Kat Manalac at the Female Founders Conference
Founded by Morgan de Bon in 2014, Blavity has evolved from a bootstrapped text-based blog into the largest media company for Black millennials, now serving over seven million readers through a community-first model that leverages user-generated content. After securing a $1 million Series A by demonstrating robust organic growth, the company successfully expanded its portfolio by acquiring Shadow and Act and launching verticals like 2190 and Afrotech conferences. De Bon's journey highlights a strategic pivot from traditional editorial control to empowering creators, overcoming early fundraising rejections by validating the unique ecosystem of Black audiences against standard industry benchmarks.
- Bank of America26 min
Small Business Financing Tips for 2017: Banks, Family and Additional Resources
Carol Roth, David Burch, Steve Strauss, Gerri Detweiler
Addressing the financing needs of over 50% of U.S. small business owners planning growth, experts including David Burch of Bank of America and Steve Strauss outline strategies to navigate traditional lending and family funding. The presentation details the critical preparation required for the "Three Cs" of credit, emphasizing accurate financial reporting and formal contracts to mitigate relationship risks with family investors. Panelists further advocate for leveraging free advisory networks like SCORE and SBDCs to build robust capital reserves before crises occur, ensuring businesses can transition from informal financing to institutional support.
- a16z21 min
Derek Belch
Founded by former Stanford coach Derek Belch, Stryver Labs applies spherical-camera virtual reality to athlete training by recording real game footage rather than using rendered graphics. The company achieved immediate traction after a quarterback's career-best performance followed a 15-minute VR review, leading to rapid adoption by seven college football teams, six NFL franchises, and pilot programs in the NBA and NHL. Stryver continues to expand its problem-first approach while monitoring lightfield technology to overcome current hardware limitations that hinder high-speed sports training.
- a16z25 min
Matthew Turk
Matthew Turk, John Luther King Jr., Rich
Cognate, a startup founded by researchers presenting new findings, commercializes an augmented reality system called "Being There" to enable remote experts to virtually collaborate with field technicians by reconstructing physical environments into navigable 3D models. The technology addresses critical technical challenges in environment modeling and annotation rendering, allowing users to independently explore scenes and apply spatially registered instructions without relying on live video streams. Currently targeting the 5.5 million U.S. field service technicians, the platform aims to reduce travel costs and equipment downtime by bridging the gap between dwindling expert availability and an increasingly inexperienced workforce.
- a16z20 min
Dan Boneh
This industry session featured four expert speakers who addressed critical developments in Bitcoin market stability, zero-knowledge proof protocols for exchange solvency, and the performance dominance of Intel's hardware-accelerated AES encryption. The presentations detailed a new cryptographic framework allowing exchanges to verify asset sufficiency without disclosing sensitive data, while also highlighting the Stanford Cyber Initiative's grant-funded efforts to guide ethical data practices. Together, these contributions provided technical and strategic insights into securing digital finance, optimizing hardware cryptography, and navigating the privacy-security trade-off in the modern technology landscape.
- a16z21 min
Jason Mars
Jason Mars, Lingjia Tang, Johann Haswell, Mike
Co-founded by University of Michigan professors Jason Mars and Lingjia Tang, the Clarity Lab spun out into Clarity Lab Inc. to commercialize its open-source voice and vision platform, originally named Sirius and later renamed Lucida by Apple. The company now offers end-to-end AI solutions like the Gin deep learning appliance and a banking-specific assistant for BankJoy, addressing a two-order-of-magnitude scalability gap in mobile personal assistants. By leveraging GPUs and FPGAs to reduce algorithmic latency by roughly ten times, these technologies transition academic research into enterprise-grade products for intelligent automation.
- a16z22 min
Michael Jordan
The speaker distinguishes inferential goals across scientific fields and identifies a critical gap between statistical decision theory and computational complexity in big data systems. New minimax theory unifies statistical inference with differential privacy, while the "Bag of Little Bootstraps" algorithm solves scalability bottlenecks by enabling parallel processing of subsampled data. This approach reduces uncertainty quantification time for terabyte-sized datasets from 15,000 seconds to under 300 seconds, facilitating robust, privacy-preserving personalization without the sensitivity of Bayesian priors.
- a16z23 min
Mark Ring
Mark Ring, co-founder of Kojitai, presents an "iso-laminar learning mechanism" that aims to transition AI from performing superficial tasks to achieving genuine world understanding through continual learning. This approach, utilizing a forecasting system developed alongside Rich Sutton, enables robotic agents to autonomously construct complex geometric abstractions like room layouts and obstacle distances from raw sensory inputs without human labeling. While technical hurdles regarding computational scale remain, Ring anticipates that solving these challenges within the next few years will revolutionize industries ranging from autonomous vehicles to intelligent search systems.
- Y Combinator27 min
Emily Weiss on the Insights That Grew Glossier - With Amy Buechler at the Female Founders Conference
Glossier, led by CEO Emily Weiss, leverages its sister publication *Into the Gloss* and a 600% annual growth trajectory to scale its Direct-to-Consumer beauty model while maintaining accidental profitability with $40 million in raised capital. The company prioritizes product quality and community transparency over traditional retail tactics, driving expansion through peer-to-peer recommendations and a strategic shift to physical locations that function as cultural hubs rather than sales counters. As Weiss directs focus toward a new European headquarters, the firm exemplifies a market shift where data-driven community engagement replaces conventional advertising to cultivate brand loyalty among a predominantly female workforce.
- a16z26 min
What Happens When Mobile (Really) Hits the Wallet
The speaker argues that the banking sector is undergoing a fundamental transformation from physical branch-based models to "Amazon-style" mobile-first ecosystems where services are disaggregated and the physical checkbook is replaced by a layered digital payment stack. This shift enables next-generation personal financial managers to utilize granular Level 3 transaction data for automated refinancing, dynamic insurance switching, and frictionless couponing, while simultaneously threatening legacy payment intermediaries that lack ownership of hardware and operating systems. To fully realize these opportunities, the industry requires open application programming interfaces from major platforms like Apple and Google to facilitate the digitization of all physical wallet items.