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  1. Milken Institute1h 1m

    Building Businesses for Impact and Purpose | Global Conference 2025

    Devi Brown, Jessica Alba, Mark Hyman, Moj Mahdara, Pritika Swarup, Quentin Vennie

    Leaders from Honest Company, Function Health, Procti Beauty, Equity, and Kinship Ventures discuss pivoting from advocacy or individual care to scalable, for-profit models that democratize access to ethical health and wellness solutions. The panel highlights critical strategies for maintaining brand integrity during rapid expansion while leveraging technology to reduce preventive care costs, such as Function Health's $4.99 MRI offering and the shift toward predictive, data-driven healthcare. By addressing systemic barriers in supply chains and investor expectations, these founders aim to transform wellness from a luxury for the few into an accessible necessity for diverse communities, including marginalized populations historically excluded from the industry.

  2. 20VC with Harry Stebbings1h 5m

    Windsurf CEO & Co-Founder, Varun Mohan: AI's Biggest Acquisition to Date!

    Varun Mohan, Harry Stebbings

    Windsurf CEO Varun strategically pivoted his company from autonomous vehicle infrastructure to Code AI, launching a proprietary IDE to deliver agentic coding tools that now derive over half its revenue from enterprise clients like JPMorgan Chase. By prioritizing rapid weekly releases and a 100% in-person culture, the startup differentiates itself from hyperscalers by competing on execution speed and deep backend specialization rather than relying on commoditized model layers. This aggressive approach aims to reduce software development time by 99% while acknowledging that future AI agents will expand beyond writing code to debugging complex systems and navigating legacy workflows.

  3. All-In Podcast1h 30m

    AI Doom vs Boom, EA Cult Returns, BBB Upside, US Steel and Golden Votes

    Chamath, Jason, Friedberg, David Sacks

    Amidst fierce debate over AI's dual impact on displacing entry-level white-collar workers while potentially lowering consumer costs and driving economic abundance, experts warn that US geopolitical strategy must prioritize winning the technology race against China to avoid strategic vulnerability. This technological urgency is compounded by a pressing fiscal crisis where mandatory spending on entitlements and debt interest consumes the majority of the federal budget, threatening Social Security insolvency within seven years without structural reform or significant GDP growth. While some advocates propose government investment in strategic industries and energy infrastructure to solve capacity constraints, others caution against state intervention in private markets, highlighting a fundamental clash between rapid technological advancement and the nation's long-term financial stability.

  4. Milken Institute1h 2m

    Road to Brazil: Preparing for COP30 | Global Conference 2025

    Sergio Gusmão, Régine Clément, Tariye Gbadegesin, Rémy Rioux, Maria Netto Schneider, Virgilio Viana

    Leading climate financiers and policymakers at COP30 are mobilizing to bridge the $8–10 trillion annual funding gap by shifting climate investment from donor pools to leveraged capital markets, exemplified by the Climate Investment Funds' recent triple-A-rated issuance. The event prioritizes systemic reforms including standardized asset classes for nature-based solutions, accelerated debt-for-nature swaps, and country-led programming to overcome bureaucratic barriers in the Amazon and emerging markets. Experts emphasized that immediate private capital deployment is critical to prevent the Amazon from reaching a climate tipping point while addressing the inefficiencies of current insurance and carbon market frameworks.

  5. a16z46 min

    Hey Tech, Come to Healthcare

    Vijay Pande, Daisy Wolf, BJ

    In a 2022 analysis, analysts BJ and Daisy predict that consumer health technology will produce the world's first trillion-dollar company by leveraging a $4 trillion U.S. market where 88% of the population faces metabolic challenges. The event details how artificial intelligence and post-pandemic cultural shifts are enabling a transition from reactive sick care to predictive, home-centric prevention while bypassing traditional incumbent barriers through new "payvider," marketplace, and financial infrastructure models. These strategies aim to unify fragmented health data and engineer behavioral change, ultimately positioning tech founders with hybrid clinical expertise to replace legacy systems with AI-driven, high-UX solutions.

  6. Milken Institute57 min

    From Experience to Excellence: Women Redefining Business and Financial Wellness | Global Conference

    Sheryl WuDunn, Sheila Marcelo, Lauren Miller Rogen, Penny Pennington, Michele Trogni, Michelle Choney

    This panel convened financial leaders, health innovators, and care advocates to address systemic failures in institutions designed around male lifespans, highlighting that women over 45 now launch businesses at twice the rate of men despite facing significantly higher chronic illness rates and lower retirement savings. Through initiatives by Zinnia, Edward Jones, Hilarity for Charity, and Ojai.ai, the discussion proposed a holistic framework integrating financial longevity, AI-driven household management, and brain health education to transition from "work-life balance" to comprehensive power. The resulting strategy advocates for redesigned risk profiles, early protective insurance planning, and intergenerational conversations to secure the $10 trillion in assets currently held by women against the projected demographic shifts in caregiving and wealth transfer.

  7. Dwarkesh Patel1h 30m

    Xi Jinping’s paranoid approach to AGI, debt crisis, & Politburo politics — Victor Shih

    Xi Jinping, Victor Shih, Dwarkesh

    Chinese leadership under Xi Jinping is accelerating AI development while simultaneously enforcing strict "kill switch" mechanisms to prevent the technology from usurping Party power, led by Ding Zhesheng's centralized oversight. This strategic focus occurs alongside a severe local debt crisis and a rigid governance structure that prioritizes political survival and state control over technical expertise or economic efficiency. Future forecasts suggest that while a full-scale invasion of Taiwan remains unlikely this decade, the regime will continue diverting resources toward AI and national defense, potentially triggering financial instability during a power transition marked by the absence of a designated successor.

  8. 20VC with Harry Stebbings1h 19m

    OpenAI’s $6BN Jony Ive Deal & YC Is Both Chanel and Walmart, and Has Officially Won!

    Jony Ive, Rory O'Driscoll, Jason Lemkin, Harry Stebbings

    Venture capital strategies for funds exceeding $6 billion now prioritize extreme capital concentration in single top-tier winners to offset the mathematical improbability of traditional fund return models. Concurrently, the AI sector is reshaping dilution dynamics and talent acquisition, with founders prioritizing engineering retention over capital provision while facing rising early-stage dilution rates of 66%. Finally, market sentiment is shifting toward stricter IPO requirements for profitability and revenue, alongside a consensus that AGI economic utility will be defined by contract leverage around 2028 rather than pure technical milestones.

  9. Jane Street1h 20m

    Building Tools for Traders with Ian Henry

    Ian Henry, Ron Minsky, Mark Mandelbaum, Mark Mirchandani, David Eastman, Brian Dorsey

    Ian Henry, a Jane Street engineer who transitioned from general web development to options trading tools, leverages the firm's custom OCaml ecosystem to build high-density interfaces that eliminate mouse usage and manage complex volatility surfaces. His recent work includes creating Bauble, a live 3D graphics environment in the Janet language that demonstrates how side projects using image-based state serialization and novel macro systems can rapidly inform internal production tooling. Through this process, Henry illustrates how Jane Street bridges the gap between low-latency exchange architecture and expert user needs by prioritizing type safety, extreme information density, and a parallel software universe free from standard web protocols.

  10. Sourcery with Molly O'Shea1h 8m

    How Wander Raised Over $100M+ to Reinvent Luxury Travel

    John Andrew Entwistle, Molly

    Wander, a verticalized vacation rental marketplace led by founder John Andrew, recently secured a Series B term sheet with QED to scale its curated inventory of top-tier properties beyond 1,000 locations. The company differentiates itself through a proprietary AI-driven operating system that automates 60% of management tasks and maintains strict brand safety standards while transitioning from an asset-heavy balance sheet to a REIT-based model. With a $40 million GMV run rate and a $100 million annual revenue target, Wander is restructuring into business units to support efficient growth toward Series C while prioritizing operational frugality and ethical cultural fit.

  11. Milken Institute1h 13m

    The Milken-Motsepe Prize in FinTech Pitches and Grand Prize Ceremony | Global Conference 2025

    Milken, Motsepe, Emily Musil, Meghan McCormick, Precious Moloi-Motsepe, Sam Njuguna, Ola Oyetayo, Jonathan Wilson

    The 2025 Milken-Motsepe Prize awarded $2 million to ten semi-finalists to support African-led FinTech innovations targeting underbanked populations, with Virto securing the $1 million grand prize for its cross-border payment infrastructure. Key figures including Mike Milken and Patrice Motsepe emphasized the program's role in leveraging Africa's demographic growth and entrepreneurship to catalyze follow-on investment and impact over one million lives since its inception. Building on this momentum, the initiative launched a new accelerator and announced an upcoming challenge cycle in AI and Manufacturing to further address financial inclusion and infrastructure gaps across the continent.

  12. a16z1h 18m

    Rick Rubin: Vibe Coding is the Punk Rock of Software

    Rick Rubin, Marc Andreessen, Ben Horowitz, Anjney Midha, Erik Torenberg

    Rick Rubin introduces "vibe coding" as a methodology merging the ancient spiritual principles of the Tao Te Ching with modern AI to democratize creation for non-technical users. The discussion outlines how this approach treats AI as a tool for human expression rather than an autonomous creator, aiming to counteract the homogenization of global culture and narrow demographic biases in current tech development. Ultimately, the event advocates for a future of education focused on cultivating taste and self-knowledge, allowing artists to leverage AI to raise creative ceilings while maintaining authentic individual agency.

  13. Milken Institute1h 3m

    Business and the Global Economy: Driving Growth and Innovation | Global Conference 2025

    Conrad Kiechel, Gerard Baker, Ajay Banga, Mariam bint Mohammed AlMheiri, Rich Lesser, Gilberto Tomazoni, Jerry Baker

    At the 28th Milken Institute Global Conference, panelists led by World Bank officials and BCG executives discussed strategies to navigate global trade fragmentation and a looming labor surplus in developing nations. The discussion highlighted the critical need for public-private partnerships to fund infrastructure and energy grids capable of supporting both AI adoption and agricultural transformation. Experts concluded that while geopolitical tensions threaten traditional globalization, targeted regional integration and regulatory reforms can unlock new growth vectors for the global economy.

  14. Milken Institute1h 1m

    The Global Quest to Reinvent the City | Global Conference 2025

    Maggie Switek, Mikkel Bülow-Lehnsby, Thomas Heatherwick, Matthew Kahn, Erin L. Murphy

    A global panel of experts and investors, including Urban Partners' Mikael Lindberg and architect Thomas Heatherwick, outlines a strategic shift toward resilient, human-centric cities that address the impending doubling of the urban population and severe climate threats in Southeast Asia. The discussion highlights the transition from fragmented asset management to integrated "live, work, play" districts, leveraging AI-driven tools and public-private partnerships to overcome the "blandemic" of sterile architecture and rising sea-level risks. Ultimately, the consensus emphasizes that aligning capital with emotional engagement and functional design will drive the economic viability necessary to build carbon sinks and adaptive infrastructure in rapidly urbanizing regions.

  15. All-In Podcast1h 2m

    Senator Ron Johnson on the Senate showdown over Trump's Big Beautiful Bill | All-In Interview

    Ron Johnson, Trump, Friedberg, Chamath, Jason

    Senator Mike Johnson warns that projecting federal spending to reach $7.3 trillion annually could swell the national debt to $63 trillion by 2035, a trajectory he argues the current House reconciliation bill fails to address. While acknowledging the limitations of budget reconciliation, he vows to vote against the legislation unless it commits to returning spending to pre-pandemic levels and codifies efficiency findings through rescission rather than broad political packages. Joined by allies like Senators Rand Paul and Mike Lee, Johnson insists that without immediate corrective measures to curb interest costs and discretionary spending, the United States risks a debt spiral that would fundamentally erode the conservative movement and the economy.