Latest Interviews
Showing 781–795 of 3,496 transcripts.
Clear all filtersHow LP Deployment to Venture Will Change in 2025 & Are Endowment Funds in Trouble?
Rory O'Driscoll, Jason Lemkin, Harry Stebbings
OpenAI is pursuing strategic acquisitions like Windsurf or Cursor to solidify its coding dominance against competitors, a move driven by a market consensus that treats AI adoption as an inevitable paradigm shift comparable to the internet era. Parallel to this corporate maneuvering, the venture capital landscape is undergoing structural compression where multi-stage firms are squeezing out pure seed funds and endowments face liquidity pressures, forcing a pivot toward high-conviction bets on outlier founders in the Bay Area. While investors prioritize capital-efficient vertical SaaS opportunities to avoid the churn associated with horizontal AI roll-ups, they remain compelled to deploy capital at elevated valuations to secure positions in potential massive exits.
Superpower Raises $30M Series A Led by Forerunner
Superpower, led by founder Jacob Peters, secured a $30 million Series A round led by Forerunner Ventures to advance its vision of replacing fragmented healthcare with an AI-driven concierge model. The company leverages a three-part architecture of data centralization, diagnostic intelligence, and action-oriented marketplace tools to provide comprehensive health monitoring at a fraction of traditional costs. By capitalizing on widespread metabolic dysfunction and Peters' personal health crisis, Superpower aims to disintermediate the current system and build a vertically integrated preventative care network.
- Sequoia Capital46 min
Pricing in the AI Era: From Inputs to Outcomes, with Paid CEO Manny Medina
Manny Medina, Pat Grady, Lauren Reeder
Manny Medina outlines a strategic pivot for AI success toward narrow, high-utility applications that replace specific Business Process Outsourcing roles rather than general-purpose creative tasks. He details four emerging pricing frameworks, particularly agent-based billing that allows companies to allocate AI costs to human resources budgets, while warning that rising inference costs are compressing margins unless vendors shift to outcome-based revenue models. Medina concludes that sustainable growth requires founders to abandon broad market ambitions in favor of deep vertical expertise, utilizing paid to track unit economics as the industry transitions from trial-based excitement to contract renewals.
- Milken Institute58 min
New Horizons for Accelerating Drug Repurposing
Dr. David Fajgenbaum, Ray, Kristen, Marianne Clancy, Christine Colvis
Hosted by TRiN and Faster Cures, this webinar featured experts from EveryCure, CURE HHT, and NCATS to examine strategies for accelerating the repurposing of existing drugs for rare diseases. Presenters detailed how AI-driven knowledge graphs and patient-led advocacy successfully navigated financial, intellectual property, and regulatory hurdles to secure approvals for conditions like Castleman's disease and Hereditary Hemorrhagic Telangiectasia. The session concluded with a consensus that generating clinical evidence and securing payment pathways are more critical than intellectual property protection for bringing generic therapies to new indications.
Dave CEO, Jason Wilk: The Best Performing Fund Would Only Back YC Founders on Their Second Time
Dave, Jason Wilk, Harry Stebbings
Dave CEO Jason Goldman details how the fintech firm reversed a 98% market capitalization decline to reach $1.13 billion by leveraging AI-driven underwriting to slash credit loss rates and achieve significant profitability without layoffs. The company utilizes cashflow-based analysis across 12 million accounts to offer low-cost credit alternatives to legacy overdraft fees, projecting continued expansion into buy now, pay later and longer-duration lending. Goldman argues that the firm's capital efficiency and removal of traditional debt structures position it to disrupt the $3 trillion credit card market, though he cautions against regulatory overreach that could stifle consumer access to fair lending.
Inside the $350M Pelosi Stock Tracker
Autopilot, formerly known as the Nancy Pelosi stock tracker, is a venture-backed fintech platform that has grown to manage $500 million in assets for 2.5 million users before pivoting to a creator economy model allowing influencers to offer tradable portfolios. The company leverages its history of tracking high-performing politicians like Nancy Pelosi and Richard Burr to highlight market timing disparities while advocating for the bipartisan "Pelosi Act" to ban congressional stock trading. Having generated eight-figure revenue without a down month, Autopilot is transitioning from a single-figure focus to a sustainable social investing ecosystem funded by roughly $7 million in venture capital.
- Sequoia Capital58 min
Arc Institute's Patrick Hsu on Building an App Store for Biology with AI
Patrick Hsu, Josephine Chen, Pat Grady
The ARC Institute, led by Patrick Hsu, has launched EVO2, a generative foundation model trained on genomic sequences across all domains of life to predict the functional consequences of genetic variants with state-of-the-art accuracy. By reclassifying Variants of Unknown Significance, this open-source tool aims to transform genetic testing outcomes and prevent unnecessary medical interventions while establishing a roadmap toward simulating virtual cells by 2030. This initiative reflects a strategic shift within ARC to merge academic rigor with industrial application, utilizing evolutionary data to build a unifying theory of biology rather than focusing solely on traditional drug design.
- The Diary Of A CEO1h 26m
No.1 Nitric Oxide Expert: Why You’re Always Tired and It’s Not Your Fault
Dr Nathan Bryan, Bryan Johnson
Dr. Nathan Bryan presents a framework identifying nitric oxide deficiency as the primary driver of age-related chronic diseases, linking vascular decline to conditions ranging from erectile dysfunction and hypertension to Alzheimer's and metabolic disorders. The presentation details how oral hygiene habits, particularly the use of antibacterial mouthwash and fluoride, disrupt the microbial conversion of dietary nitrates into bioactive nitric oxide, while advocating for specific lifestyle interventions like sugar elimination and nasal breathing to restore endothelial function. Bryan concludes by critiquing the pharmaceutical industry's reliance on chronic disease management and calls for a clinical shift toward early intervention that prioritizes restoring natural biological pathways over managing symptoms.
Tom Hulme & Stan Boland: Lessons from Jensen Huang & How to Fix the UK Tech Ecosystem
Tom Hulme, Stan Boland, Jensen Huang, Harry Stebbings
A panel of experts warns that the UK risks falling behind the US in wealth generation due to a chronic venture capital shortfall, a talent gap exacerbated by brain drain, and structural barriers in tax and education policy. To reverse this trend, the speakers propose a strategic pivot toward specialized sectors like defense and semiconductor design, alongside concrete reforms such as redirecting R&D tax credits into concentrated fund-of-funds models and aggregating pension capital to unlock billions in private investment. This roadmap aims to generate $4 trillion in tech wealth over two decades by aligning public policy with the needs of high-growth hardware and AI infrastructure companies rather than generic consumer applications.
Base Power's $200M Series B | Co-Led by Lee Fixel, A16Z, Lightspeed, & Valor Equity Partners
Lee Fixel, Zach Dell, Justin Lopas, Antonio Gracias, Molly
Base Power, founded in 2023 by Zach and Justin, closed a $200 million Series B round led by Addition with new participation from Andreessen Horowitz and Lightspeed Ventures to accelerate its "violent execution" culture and vertical integration strategy. Leveraging an isolated grid launch in Texas and a proprietary utility model that reduces deployment timelines to 2–4 weeks, the company has installed over 1,000 batteries while securing partnerships with builders like Lennar and utilities such as Bandera. Backed by a talent pool drawn from SpaceX and Tesla, Base Power now aims to scale operations to 50–100 daily installations and expand across all 50 states to address surging electricity demand from AI data centers and electrification.
- Sequoia Capital1h 26m
A Better End State than AGI? Replit CEO Amjad Masad on 1 Billion Developers
Amjad Masad, David Cahn, Sonya Huang
Replit co-founder Amjad Massad argues that while near-term AI excels at data-rich tasks like coding and mathematics, creative problem-solving remains a distinctively human capability, setting the stage for a "billion developers" economy. Following a 2024 strategic pivot to prioritize agent development, the company launched Replit Agent Version 2, which leverages Anthropic's Sonnet 3.5 to automate entire software lifecycles and drive a tenfold increase in app deployments. This shift democratizes global software creation by enabling non-technical sectors to build tailored solutions, transforming users from passive consumers into "creative engines" that leverage AI to multiply productivity.
Carvana CEO & Co-Founder, Ernest Garcia: Building a $50B Company, Losing 99% and Coming Back
Ernest Garcia, Harry Stebbings
Carvana founder Dan Saks describes the company's volatile journey from a near-death capital crisis and a 99% stock decline to operational resilience, driven by a strategic rejection of software-layer models in favor of complex vertical integration. The organization now prioritizes hiring practical operators over strategists and utilizes AI to enhance efficiency while maintaining a flat hierarchy designed to maximize direct problem-solving. Looking forward, Carvana aims to balance growth with foundational stability, leveraging its massive inventory infrastructure to scale toward millions of vehicles while adhering to Benjamin Graham's principle that public markets eventually reward genuine results over short-term sentiment.
- Jane Street47 min
Making OCaml Safe for Performance Engineering
Jane Street's research introduces a suite of OCaml extensions featuring unboxed types and stack allocation to eliminate memory waste and garbage collection overhead in performance-critical applications. These innovations expand into a static mode system that guarantees data race freedom for parallel execution by enforcing lifetime and portability constraints without explicit annotations. Currently deployed in production for memory management features and undergoing beta testing for concurrency safety, this work aims to integrate into mainline OCaml while earning a POPL award for its formal verification of race freedom.
- The Economist47 min
Import-extort: what to make of Donald Trump’s titanic tariffs
Donald Trump, Mike Bird, Ethan Wu, Simon Rabinovitch, Douglas Irwin, Doug Irwin
On April 2, 2025, President Donald Trump invoked national emergency powers to impose a baseline 10% tariff on all imports alongside reciprocal rates targeting nations like China and the European Union, effectively raising the U.S. tariff level to approximately 25%. This unilateral executive action, which exempts Mexico and Canada while closing the de minimis e-commerce loophole, aims to restore domestic manufacturing but faces imminent legal challenges under the International Emergency Economic Powers Act. Economic analysts warn the policy could trigger stagflation with inflation reaching 5% and reduce GDP by 0.6%, yet global markets have initially reacted with falling bond yields despite alarm from oil, gas, and apparel sectors reliant on imported inputs.
- a16z53 min
Can the Military Move at Startup Speed? How the Army and Navy Are Rebuilding
Alex Miller, Justin Fanelli, Leila Hay
DoD leadership is dismantling legacy Cold War-era acquisition structures to replace rigid, decade-long procurement cycles with agile "Military Moneyball" approaches that prioritize speed and overmatch over incremental improvements. By leveraging Software Acquisition Pathways, OTAs, and direct startup partnerships, the Army and Navy are accelerating capability delivery from eighteen months to three while consolidating legacy systems to fund disruptive technologies like AI and autonomous swarms. This strategic pivot aligns military "outcome-driven" metrics with commercial venture speed, enabling rapid fielding of solutions ranging from mobile command apps to counter-drone networks without traditional bureaucratic barriers.