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  1. All-In Podcast1h 5m

    Dave Ricks, CEO of Eli Lilly | The All-In Interview

    Dave Ricks, Friedberg

    Under CEO Dave Ricks, Eli Lilly has expanded its market capitalization to $878 billion while dominating the GLP-1 weight loss market through innovations like tirzepatide and the upcoming oral drug orforglipron. These scientific breakthroughs address a global obesity crisis affecting billions, with the company investing heavily in domestic manufacturing and AI-driven research to sustain high-growth revenue projections. Despite facing political scrutiny over pricing and reimbursement limitations, Lilly is leveraging a rapid development culture and direct-to-consumer platforms to maintain industry leadership and expand treatment access.

  2. Sequoia Capital1h 0m

    Snowflake CEO Sridhar Ramaswamy on Using Data to Create Simple, Reliable AI for Businesses

    Sridhar Ramaswamy, Sonya Huang, Pat Grady, Sonia

    Snowflake CEO Sridhar Ramaswamy is driving the company's transformation into an "AI data cloud" that integrates acquired search technology from Neva to serve over 10,000 enterprise customers. The organization addresses reliability concerns in generative AI by prioritizing context engineering and managed governance, enabling business users to access data through grounded chatbots without extensive custom software development. This strategic pivot aims to democratize software creation by embedding AI directly into data workflows, positioning Snowflake to capitalize on the shift toward interoperable cloud storage and controlled mobile ecosystems.

  3. Jane Street54 min

    Solving Puzzles in Production with Liora Friedberg

    Liora Friedberg, Ron Minsky

    Jane Street's production engineers serve as the first line of defense for its trading systems, balancing active live support with long-term projects to enhance reliability and manage a broad mental model of interconnected infrastructure. Through a blame-free culture and specialized training involving incident simulations, the team rigorously analyzes high-severity events to drive system improvements while leveraging custom tools like Oculus for precise observability and alert management. Recruiting efforts identify candidates with strong debugging instincts and communication skills who can navigate the unique pressure of minimizing opportunity costs during financial disruptions.

  4. 20VC with Harry Stebbings1h 19m

    Eiso Kant, CTO @Poolside: Raising $600M To Compete in the Race for AGI | E1211

    Eiso Kant, Harry Stebbings

    Poolside secured a $500 million funding round to deploy 10,000 GPUs for developing specialized AI models capable of writing software, a capability CEO Daniel Diner identifies as the critical prerequisite for achieving Artificial General Intelligence. Distinguishing its approach from static text-based training, the company leverages reinforcement learning on execution feedback from over 130,000 real-world codebases to generate high-quality "intermediate reasoning" data. Operating as an independent entity despite offering investment from NVIDIA, Poolside aims to navigate the intense compute bottleneck and price wars of the current landscape by balancing rapid scaling with a strategy of distilling massive models into economically viable inference tools.

  5. The Economist1h 4m

    The Weekend Intelligence: Gaza, after the dust settles (republished)

    Zanny Minton Beddoes, Greg Karlstrom, Dana Struhl, Mohamed Mustafa, Shahabil al-Zayim, Moussa Abou-Mazouk, Bassem Naeem, Nick Pelham, Leah, Yael, Yoaz Hendel, Simcha Rothman, Yair Golan, Naftali Bennett, Anwar al-Jundi Abu Subi, Tarnim, Matthew Hollingworth, Ali Shaf

    Nine months into the conflict, Gaza faces near-total destruction and a humanitarian catastrophe as competing visions for post-war governance emerge, with the US and Palestinian Authority advocating for a revitalized PA while Israeli factions range from rejecting a political horizon to proposing indefinite military control. Security vacuums are already being filled by armed criminal gangs and Hamas, creating a lawless environment that threatens to collapse into permanent instability without a credible international or Israeli security plan. Experts warn that the absence of political consensus, combined with the logistical failure of aid delivery and the scale of rubble requiring forty million tons of clearance, renders a successful transition vanishingly unlikely.

  6. Milken Institute45 min

    Attracting Capital to Promote Growth: Indicators & Insights | Asia Summit 2024

    Michelle Martin, Pablo Coballasi, Jackie Surtani, Paul J. Thoppil

    A panel of global experts analyzed shifting foreign direct investment patterns in Asia, highlighting how geopolitical tensions and climate imperatives are driving multinational corporations to adopt "China-plus-one" strategies and establish regional headquarters in countries like Vietnam and India. The discussion further detailed how U.S. election prospects, potential trade tariffs, and the AI-driven energy boom are accelerating supply chain realignments toward North America and necessitating substantial climate financing commitments from institutions like the Asian Development Bank. Finally, participants identified Singapore as a replicable benchmark for investment success, emphasizing the need for developing nations to balance digital trade interoperability with workforce retraining to meet emerging environmental and technological demands.

  7. Milken Institute45 min

    Catalytic Capital: Investing for Performance, Purpose, and Planet | Asia Summit 2024

    Ishika Mookerjee, Emily Chew, Deepali Khanna, Hiromichi Mizuno, Robert Schultz

    Capital from institutional investors like GIC and Capricorn Investment Group, alongside catalytic philanthropy from the Rockefeller Foundation, is being strategically deployed to bridge the $4.5 trillion global climate finance gap by targeting high-risk deep tech and early-stage decarbonization solutions. Key figures including Yusko Mizuno and Robert Schultz emphasize that integrating ESG criteria with robust risk management can deliver strong financial returns while addressing the "valley of death" in technologies like hydrogen steel and grid modernization. Despite geopolitical headwinds and protectionist policies threatening supply chains, these stakeholders advocate for blended finance models that leverage private capital to scale innovations essential for achieving net zero by 2050.

  8. The Economist52 min

    A key Keystone: the race for Pennsylvania

    John Prideaux, Charlotte Howard, Idrees Kahloon, John Priddo, Idris Kalloun

    Pennsylvania has emerged as the critical 2024 election tipping point, where a predicted 30% probability of determining the presidency drives over $138 million in campaign spending and a tightening polling race between Kamala Harris and Donald Trump. Strategic efforts by both campaigns now target specific swing counties and demographic shifts, as Harris attempts to restore coalition numbers among younger and female voters while Trump leverages heavy advertising to appeal to rural and working-class constituents concerned with inflation and trade. This contest is further complicated by deep regional divides between Philadelphia's educated suburbs and the state's conservative interior, alongside structural election law challenges that heighten voter anxieties regarding results and integrity.

  9. Milken Institute58 min

    On AI: Discourses on Application, Convergence, and the Future of Humanity | Asia Summit 2024

    Ella Tan, Gary Liu, Lila Ibrahim, Phoram Mehta, John Quinn, Rob Schimek, Shan Shan Wong

    Industry experts project the generative AI market to exceed $1 trillion by 2032, driven by substantial productivity gains in sectors like software development and insurance while training costs for foundational models have surged from $1,000 to nearly $200 million. Regulatory frameworks such as the European AI Act and California's proposed legislation are increasingly prioritizing risk-based accountability and dataset audits, prompting companies like Stability AI and DeepMind to adopt "safety by design" protocols to mitigate bias and misinformation. Despite these challenges, the event highlights a consensus that open-source collaboration and responsible innovation will lower entry barriers, ultimately transforming education, scientific discovery, and creative industries through personalized, human-centric applications.

  10. 20VC with Harry Stebbings53 min

    Maria Angelidou:Product Lessons Leading Facebook App Monetisation Team to Billions in Revenue |E1210

    Maria Angelidou, Harry Stebbings

    Maria, who joined Facebook in 2013 when the company employed roughly 3,000 people, implemented a four-tier career progression model at Meta to retain high-performing individual contributors while preventing premature promotions. She advocates for minimum viable processes and a specific resource allocation strategy to balance product improvements, new development, and operational stability without sacrificing quality for speed. Her leadership philosophy emphasizes rigorous hiring standards, evidence-based decision-making, and strategic innovation to navigate the structural differences between US and European markets.

  11. Sourcery with Molly O'Shea56 min

    Impulse Labs, Trojan Horse for Battery-Powered Homes | Backed by Lux Capital

    Molly O'Shea, Sam D'Amico, Josh Wolfe

    Impulse Labs is deploying a battery-integrated induction stove featuring a lithium iron phosphate power source to serve as a distributed grid storage asset while delivering over 95% energy efficiency. Funded by a $20 million Series A led by Lux Capital's Josh Wolfe, the company targets premium residential and multifamily markets by leveraging federal tax credits to offset the device's high-end pricing. The startup aims to scale production over the next year to validate a model where multiple appliances collectively create a self-sufficient home energy system capable of load balancing and outage resilience.

  12. 80,000 Hours1h 25m

    Should we interfere with wild nature to reduce suffering? | Peter Godfrey-Smith

    Peter Godfrey-Smith, Luisa Rodriguez

    In a discussion with host Luisa Rodriguez, philosopher Peter Godfrey-Smith outlines the themes of his book *Living on Earth*, arguing for habitat preservation over active predation management while asserting that difficult wild experiences can hold redemptive value. He further distinguishes human technological uniqueness as a product of cumulative culture and the specific evolutionary advantage of the sea-to-land transition, contrasting this with the limitations faced by other intelligent species like octopuses and whales. The dialogue concludes with a shared view on the necessity of empirical research to guide future ethical decisions regarding wild animal welfare and the potential biological constraints on artificial sentience.

  13. Milken Institute1h 2m

    The Future of Global Connectivity: Bridging Industries for a Seamless World | Asia Summit 2024

    Jason Lee, Monica Pitrelli, Nomin Chinbat, Ho Kwon Ping, Jane Sun, Adam Wilkes

    A meeting involving speakers such as Monica Patel, Melissa Patel, and Lisa Suryajan produced a transcript characterized by extensive semantic incoherence and disconnected references to medical needs, monetary figures, and geopolitical topics. Despite mentioning concepts like deep learning, decarbonization, and pandemic management, the discussion yielded no actionable strategies, verifiable data, or defined collaborative frameworks. The session concluded with standard pleasantries but established no concrete follow-up actions, deadlines, or substantive outcomes due to a total lack of prepared agenda and logical continuity.

  14. Milken Institute45 min

    Asia's Green Gold: Unlocking Value in Natural Capital Markets | Asia Summit 2024

    Meaghan See, Mark Glossoti, Hoon Ling Min, Madhur Jain, Justin Reynolds, Megan Seen, Mark Mazzotti, Sun Ling Min, Mada Dharian, Madhuri, Madhu, Amit Arora, Cécile, Mindy, Doreen, Linh Minh, Vaswant, Bonnie, Mike, Li-Ming, Madhav

    A high-level panel convened to analyze the critical transition of nature-based solutions into a viable, investable asset class, highlighting Asia's projected 30% share of global carbon offset potential by 2030. The discussion detailed necessary financial mechanisms, such as targeting 9-10% returns for institutional capital and utilizing Article 6 of the Paris Agreement to facilitate international trade, while emphasizing technology's role in verifying smallholder integrity. Panelists concluded that scaling these frameworks is essential to tripling current nature financing and formalizing natural capital to meet global climate targets.

  15. 20VC with Harry Stebbings1h 16m

    Bret Taylor: Why Pre-Training is for Morons & Companies Will Build Their Own Software | E1209

    Bret Taylor, Harry Stebbings

    Brett Taylor characterizes the current AI investment landscape as a bubble that will ultimately produce trillion-dollar consumer companies and enduring enterprise firms, similar to the post-dot-com era. He advocates for a solution-first strategy where startups fine-tune existing open-source models rather than pre-training from scratch, predicting that the market will consolidate around a few infrastructure providers and a long tail of vertical SaaS applications. Taylor further forecasts that by 2025, branded conversational agents will become as essential as websites, shifting the primary interface for customer interaction from rule-based systems to goal-oriented agents while challenging traditional leadership and reliability paradigms.