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  1. The Diary Of A CEO1h 51m

    No. 1 Sugar Expert: You've Been Sold A Lie About "Healthy" Food!

    Dr. Robert Lustig

    Robert Lustig synthesizes a biological framework linking ultra-processed foods and non-nutritive sweeteners to dementia by detailing how reactive oxygen species deplete mitochondrial ATP and trigger amyloid plaque formation. The presentation contrasts these environmental drivers with metabolic interventions like ketogenic diets and dopamine regulation, while explicitly rejecting the GLP-1 analog approach in favor of systemic food reform that could save the healthcare system trillions. Furthermore, Lustig addresses public health policy by defending vaccine efficacy, advocating for the removal of sugar from food subsidies, and urging individuals to utilize continuous glucose monitoring to bypass algorithmic echo chambers.

  2. All-In Podcast14 min

    Multicoin Capital’s Kyle Samani on Internet Capital Markets

    Kyle Samani

    At the All In Summit, Multicoin Capital founder Kyle Simani argued that the convergence of scalable blockchain infrastructure and pro-crypto executive orders under the Trump administration is creating a historic inflection point for global capital markets in 2025. New legislative frameworks like the Genius Act and SEC Chair Paul Atkins' directive to update antiquated rules are expected to unify trading, settlement, and media into borderless "super apps" that eliminate legacy intermediaries. Simani predicts this regulatory and technological shift will not merely adapt the existing financial system but will consume its functions, replacing traditional TV analysts with social finance platforms and embedding trading directly into everyday digital behaviors.

  3. Milken Institute29 min

    Singapore Defence Minister & Coordinating Minister for Public Services, Chan Chun Sing | Asia Summit

    Chan Chun Sing, Laura Deal Lacey

    Amidst global economic stagnation and rising political fragmentation mirroring the pre-World War II era, this event examines strategies to counteract protectionism through deliberate cooperation between governments and the private sector. Singapore's leaders outline four enduring competitive advantages—long-term policy consistency, progressive rule of law, strategic partnerships, and the SkillsFuture initiative—to demonstrate how investment in human capital can maintain social cohesion. The presentation concludes with a call for industry leaders to advocate for integrated global rules and prioritize workforce upskilling, ensuring that technological progress translates into shared prosperity rather than nativist backlash.

  4. Milken Institute47 min

    The State of Global Capital Markets and the Future of Finance | Asia Summit 2025

    Richard Lui, David Chua, Michael Goosay, Hisham Hamdan, Noriko Honda Chen

    A panel of investment experts analyzed the diverging returns between emerging and developed markets, highlighting Asia's undervalued status despite its dominance in global GDP and growth. The discussion identified a strategic shift toward a "third wave" centered on India and Japan, driven by regulatory reforms, demographic trends, and the need for active management to overcome state-owned enterprise inefficiencies. Participants concluded that navigating liquidity risks, deglobalization, and the AI boom requires skilled investors to capitalize on structural transitions while balancing commercial returns with evolving social mandates.

  5. All-In Podcast23 min

    Rick Caruso on California’s Collapse: Broken Leadership, LA Wildfire Failures & the Fix

    Rick Caruso, Karen Bass, Chamath, Jason

    In the wake of the Palisades fires, developer Rick Caruso contrasts his private sector emergency preparations against the city's failures, blaming incompetent governance under Mayor Karen Bass for the destruction of 90% of the homes. Caruso argues that ideological politics have paralyzed local authorities, leading him to propose a competency-based administration that enforces zero tolerance for street encampments while simultaneously securing federal aid and infrastructure upgrades for rebuilding. As he evaluates potential political bids, Caruso emphasizes that California must prioritize practical solutions over political maneuvering to reverse systemic decay and restore the state's status as a national leader.

  6. Lex Fridman4h 34m

    Pavel Durov: Telegram, Freedom, Censorship, Money, Power & Human Nature | Lex Fridman Podcast #482

    Pavel Durov, Lex Fridman

    Telegram CEO Pavel Durov guides the billion-user platform, which he owns entirely with a lean 40-person engineering team, to achieve 2024 profitability by prioritizing user privacy, speed, and self-funded innovation without external shareholders. Durov has repeatedly resisted state pressure from France, Russia, and Iran to compromise on encryption or censorship, facing arrest, travel bans, and poisoning attempts while maintaining a business model that relies on Premium subscriptions and blockchain integration rather than data monetization. This resilience is supported by Durov's extreme personal discipline and philosophical stance on self-restriction, which together sustain an ecosystem designed to protect free speech and technical sovereignty against both government censorship and addictive algorithmic models.

  7. All-In Podcast25 min

    Arm CEO Rene Haas on AI: Nvidia Lessons, Intel’s Decline and the US-China Chip War

    Rene Haas, Jensen Huang, David, Jason

    Following a landmark September IPO that vaulted its valuation to $150 billion, Arm is leveraging its foundational IP to transition from a smartphone architecture provider into a strategic partner for Nvidia and a supplier for the emerging "Physical AI" robotics market. Chief Executive Officer Rene Haas is aggressively reshaping the company's global culture and engineering focus to accelerate speed-to-market, while explicitly navigating complex geopolitical frictions and supply chain constraints to maintain a unified global ecosystem. With its architecture underpinning critical advances in both data center training chips and energy-efficient endpoint inference, Arm is positioning itself to dominate a diverging semiconductor landscape where specialized hardware will define future AI capabilities.

  8. The Economist9 min

    Will President Trump’s Gaza peace plan work?

    Trump, Gregg Carlstrom, Rosie Blau, Rosie Bloor

    Donald Trump unveiled a comprehensive 20-point plan for Gaza that mandates Hamas to release all hostages and disarm in exchange for an international peacekeeping force and a Board of Peace co-led by the former president. While the proposal includes immediate humanitarian aid and a long-term governance framework, it faces significant friction due to Israeli Prime Minister Benjamin Netanyahu's opposition to Palestinian Authority involvement and divergent views on establishing a Palestinian state. The initiative places direct pressure on both Hamas to accept terms before facing potential unilateral action by Israel and on the Israeli government to adhere to the stipulated governance structure despite internal disagreements.

  9. a16z52 min

    Building an AI Physicist: ChatGPT Co-Creator’s Next Venture

    Anjney Midha, Liam Fedus, Ekin Dogus Cubuk

    Founded by co-creators of ChatGPT and DeepMind physicists, Periodic Labs operates a frontier AI research facility dedicated to advancing physical science by coupling Large Language Models with automated high-throughput experimentation. The organization deploys a unique "mid-training" methodology and physically grounded reward functions to overcome the epistemic limits of current models, specifically targeting the discovery of high-temperature superconductors exceeding 200 Kelvin. By integrating ML scientists, experimentalists, and simulators into a unified workflow, the company aims to replace theoretical predictions with real-world data loops, eventually expanding its "AI physicist" capabilities to serve aerospace, defense, and semiconductor industries.

  10. RAISE Summit19 min

    Alok Sama & Nikesh Arora: AI, Cybersecurity, and Bold Leadership

    Alok Sama, Nikesh Arora

    The event outlines a systemic shift toward the democratization of intelligence, where agentic AI transforms search, disrupts traditional ride-sharing economics through autonomous fleets, and expands cybersecurity threats into state-sponsored warfare. Parallel to these technological shifts, the discussion contrasts high-risk investment strategies at SoftBank with Palo Alto Networks' disciplined acquisition model of retaining founders to build unified security platforms. The presentation concludes by warning of an imminent quantum computing vulnerability that threatens current encryption standards before defenders can establish quantum-safe protocols.

  11. RAISE Summit20 min

    Dr. Uri Yerushalmi, Co-Founder&CAIO, Fetcherr: How AI Driven Decision Maximizes Business Performance

    Dr. Uri Yerushalmi, Uri Arushalmi

    Uri Arushalmi, Chief AI Officer of Fetcher, presents Large Market Models as a quantitative evolution beyond current generative AI, utilizing deep learning on complex market data to simulate probabilistic dynamics rather than just processing text. These systems integrate internal and external data to run computational simulations that select policies maximizing revenue, successfully generating statistically significant revenue uplifts exceeding 10% in A/B testing. By enabling proactive anticipation of market shifts instead of reactive responses, this approach allows organizations to define competitive outcomes through structural market access rather than traditional operational metrics.

  12. RAISE Summit18 min

    Mike Mattacola, CBO of CoreWeave: Building the Next Generation of Cloud in Europe

    Mike Mattacola, Michael

    CoreWeave announced an all-stock acquisition of Core Scientific to secure over 1.3 gigawatts of U.S. power capacity, while its revenue surged from $15.8 million to nearly $2 billion driven by strategic partnerships with major AI firms like Mistral and NVIDIA. The company is aggressively expanding European infrastructure with €1 billion in investments across six data centers and a seventh pipeline, utilizing a global supply chain strategy to mitigate local capital and talent shortages. Looking ahead, CoreWeave aims to lead industry consolidation by focusing on rapid capacity deployment and talent acquisition rather than active mergers, positioning its Blackwell and future Rubin hardware to support the next generation of high-performance computing.

  13. RAISE Summit21 min

    Alexis Ohanian, Founder, 776, Reddit & Victorien Tixier, CEO, ScorePlay: The Future of AI in Sports

    Alexis Ohanian, Victorien Tixier, Vic

    At an industry conference, Reddit co-founder Alexis Ohanian interviewed Scoreplay CEO Vic LaRosa to discuss how artificial intelligence will commoditize content production while elevating live sports as the premier vehicle for authentic, real-time human connection. Their dialogue highlighted Scoreplay's mission to replace legacy infrastructure with centralized AI automation for media asset management, a strategy designed to unlock global market reach through instant localization and data-driven camera placement. The conversation further emphasized a strategic pivot toward women's sports, where Ohanian argues that re-underwriting assets from first principles and leveraging digital-first storytelling will drive exponential valuation growth and reshape traditional league dynamics.

  14. RAISE Summit19 min

    Jennifer Tejada, CEO&Chairperson, PagerDuty: Never Miss a Beat Building Reliable Experiences with AI

    Jennifer Tejada, Tyson Singer

    Spotify and PagerDuty are leveraging artificial intelligence and standardized infrastructure to address a 43% surge in major operational incidents that cost enterprises nearly $1 million each. By shifting from a pet-centric to a cattle-centric philosophy, Spotify enforced rigid "golden paths" through its Backstage platform, a move that enabled fleet-wide code transformations and the commercialization of its internal tools as the B2B "Portal" product. This evolution toward automated digital resilience and code remediation prioritizes predictability over developer autonomy, allowing Spotify to manage its massive codebase while transforming into a higher-margin infrastructure provider.

  15. RAISE Summit10 min

    Jack Collier, Chief Growth & Marketing Manager, IO.Net: Why Open Models Need Open Infrastructure

    Jack Collier

    A recent analysis identifies a critical infrastructure bottleneck where centralized control of compute power and API dominance force 70% of users toward closed-source models despite 83% preferring open alternatives. To dismantle these barriers, io.net leverages a global distributed network of over 1,000 GPUs to slash costs from $15 to $3.50 per million tokens while offering transparent, blockchain-verified access for training and inference. The platform is further expanding its ecosystem through a new "Training as a Service" feature and an inaugural hackathon, aiming to accelerate the shift toward a permissionless, decentralized AI future.