Latest Interviews
Showing 2686–2700 of 6,431 interview transcripts.
Clear all filters- Goldman Sachs10 min
Biopharma opportunities and macro challenges: A check-up on the industry
Asad Haider, Chris Shibutani, Salveen Richter, Sylvain
Major pharmaceutical and biotech leaders converged to identify GLP-1 agonists and AI integration as primary drivers for a market revised upward to $130 billion, while strategically addressing patent cliffs through aggressive external collaborations and M&A targeting metabolic and neurology assets. Although the biotech IPO window has reopened with nine clinical-stage offerings, investor sentiment remains sensitive to interest rate trajectories and the need for immediate commercial validation of AI-driven discoveries. Consequently, industry capital allocation prioritizes balancing near-term revenue generators with long-term growth catalysts to navigate complex clinical challenges in the central nervous system and cardiovascular disease sectors.
- The Economist25 min
Joe of good faith: Biden bows out
Joe, Biden, Kamala Harris, Dr Ruth, Rosie Bloor, Jason Palmer, John Priddo, Leo Morani, Anne Rowe, Jerry
Following a debate performance that eroded public confidence, President Joe Biden withdrew from the 2024 race and immediately endorsed Vice President Kamala Harris, positioning her to potentially become the first female president despite her lack of a proven national election record. While political analysts warn that the public still associates Harris with Biden's approval ratings and note her previous unsuccessful primary run, the party faces a competitive field led by governors and senators before the mid-August convention. Concurrently, the administration's legacy remains precarious as the upcoming election could overshadow recent legislative victories in climate and economic recovery, leaving the Democratic strategy to pivot on whether a competent opponent can capitalize on Donald Trump's polarizing nature.
- The Diary Of A CEO2h 7m
The Healthy Ageing Doctor: Doing This For 30s Will Burn More Fat Than A Long Run! Dr Vonda Wright
Orthopedic surgeon Dr. Vonda Wright challenges the inevitability of age-related decline by presenting MRI evidence and experimental data proving that active lifestyles, specifically heavy weightlifting and strategic cardio, can preserve muscle mass, bone density, and joint function decades past age 30. Her research highlights that consistent strength training elevates longevity markers like the klotho protein and reverses cellular aging, while targeted interventions such as eliminating simple sugars and optimizing protein intake prevent the rapid atrophy often seen during menopause and male aging. By advocating for a four-component daily mobility regimen and a shift from weight loss to body composition recomposition, Wright aims to help individuals maintain functional independence and surpass traditional frailty thresholds well into their eighties and nineties.
- All-In Podcast1h 16m
Trump assassination attempt, Secret Service failure, Inside the RNC, VC liquidity problem
Trump, Chamath, Jason, Friedberg, Nick, Freeburg
Following a failed assassination attempt by Thomas Matthew Crooks that killed one attendee and injured others, the Republican National Convention solidified a coalition between MAGA populists and tech interests by selecting J.D. Vance as Donald Trump's vice-presidential running mate. The hosts analyzed the event's security failures, debated the impact of political rhetoric on the violence, and examined the administration's potential shift toward isolationist trade policies and regulatory changes regarding Big Tech. Simultaneously, the discussion highlighted significant venture capital developments, including Stripe's liquidity deal and Google's potential acquisition of Wiz, while predicting President Biden's imminent withdrawal from the race due to declining donor confidence.
- Y Combinator14 min
Tarpit Ideas: The Sequel
YC partners Dalton and Michael define "tar pit" ideas as market spaces that appear highly attractive but historically fail due to a lack of genuine technological shifts or fundamental behavioral changes. While Large Language Models have rendered some previously impossible ventures viable, founders must demonstrate concrete problem-solving capabilities rather than relying on social validation or assuming the first successful iteration is imminent. This dynamic framework warns against behavioral coordination failures and fast wealth arbitrage, urging entrepreneurs to rigorously validate ideas against historical precedents and actual user needs.
Cameron Adams: How Canva Builds Products: Lessons Learned, What Works? What Flopped? | E1179
Cameron Adams, Lars Rasmussen, Jens Rasmussen, Mel, Cliff, Harry Stebbings
Co-founder Cliff Obenshain guided Canva from a failed startup pivot to a browser-based platform that democratizes design for non-experts by prioritizing user delight over speed. The company leverages a neutral AI infrastructure to serve over 100 million users while rejecting aggressive competition strategies in favor of creating a new category of visual tools for the global majority. With more than half its 2,000-strong workforce dedicated to R&D, Canva continues to navigate complex technological shifts and environmental challenges through careful feature rollouts and a focus on deep product instincts.
- The Economist24 min
Dicky birds: the next pandemic?
Rosie Bloor, Rebecca Jackson, Kunal Patel, Adam Roberts
Former Judge Heather Hallett's pandemic inquiry report concluded that the UK government failed the public due to critically flawed preparedness, while scientists warn that H5N1's mammalian adaptations pose a distinct pandemic risk despite ongoing mRNA vaccine trials. New historical research from Ohio State University reveals that white women in New Orleans were active participants in the slave trade, utilizing the institution to accumulate independent wealth under 19th-century legal frameworks. Concurrently, The Economist has launched "Dateline," an interactive game designed to engage news-averse readers through historical archive challenges, and Editor-in-Chief Zannie Minton-Beddoes will address the aftermath of the Gaza war in the upcoming Weekend Intelligence.
- 80,000 Hours2h 24m
Navigating the geopolitics of US–China AI competition | Sihao Huang
A 2040 scenario where AI achieves human-level capability necessitates urgent global coordination to prevent existential conflicts arising from a superintelligence race between the United States and China. Current analysis highlights significant constraints on China's frontier progress due to US semiconductor export controls, yet warns that authoritarian regimes may leverage AI for automated repression and biological or cyber warfare. Immediate diplomatic efforts must establish mutual safety verification and continuous dialogue channels to mitigate the risks of pre-emptive military action while navigating complex domestic regulatory and industrial policies.
- The Economist26 min
Veep show: America meets J.D. Vance
J.D. Vance, Donald Trump, Rosie Bloor, Jason Palmer, Adam O'Neill, Kinley Salmon, Kenneth Kukie
Republican vice presidential nominee J.D. Vance delivered a populist speech emphasizing his working-class roots and isolationist economic views to differentiate himself from Donald Trump and reshape the GOP's intellectual foundation. Meanwhile, economists identify Latin America's severe trade underperformance as a result of geographical barriers, economic homogeneity, and political fragmentation that limit intra-regional commerce. Finally, Kenneth Kukie argues that classic literature such as *The Trial* and *Macbeth* provides more profound insights into leadership and organizational chaos than contemporary management manuals.
Pedro Franceschi: What Brex Needs to do to be a Public Company | E1178
Pedro Franceschi, Harry Stebbings
Pedro Franca outlines a dual-pillar framework for startup success that prioritizes the 50/50 balance between initial team and idea validation and a decade-long execution phase, while emphasizing mental health resilience as a critical component of founder endurance. As Brex CEO, Franca details the company's strategic evolution from capital-intensive scaling to a centralized, single-roadmap execution model designed to solve enterprise bottlenecks and establish the revenue predictability required for an IPO. He argues that sustainable growth relies on shifting the competitive narrative from commodity savings to complex global financial infrastructure, ensuring founders maintain authentic leadership and psychological well-being to navigate the exponential complexity of scaling a major fintech firm.
- The Economist23 min
Food for thought: raising the world’s IQ
Jason Palmer, Rosie Bloor, Robert Guest, Shashank Joshi, Emily Steinmark
The event examines the critical impact of early-life malnutrition on cognitive development and global economics, highlighting the success of Uganda's NutriCash pilot and the potential for $12 billion in targeted investment to reverse slow progress. Concurrently, analysts assess growing geopolitical threats to the 600 undersea fiber-optic cables sustaining global telecommunications, noting state-sponsored sabotage risks from Russia and China alongside the strategic vulnerability of limited repair infrastructure. Finally, the discussion presents a breakthrough in menstrual product innovation where alginate polymers transform blood into a firm gel, marking the first significant design evolution since the 1931 applicator tampon.
- Goldman Sachs29 min
Canva CEO Melanie Perkins on growing an idea into a multibillion-dollar design company
Canva, led by co-founders Melanie Perkins and Cliff Obrecht, has scaled to serve 165 million users and 90% of Fortune 500 companies by leveraging a bottom-up adoption strategy and its proprietary Magic Studio for AI-driven design automation. The company recently pivoted toward "wall-to-wall" enterprise deployment while maintaining profitability, a trajectory supported by its strategic acquisition of visual AI firm Collido and a dedicated trust and safety framework. Guided by a dual mission of commercial growth and social impact, Canva plans to expand its ecosystem to one billion monthly active users by donating equity and profits to eradicate extreme poverty.
- a16z1h 31m
Trump Vs. Biden: Tech Policy
Trump, Biden, Marc Andreessen, Ben Horowitz
Marc Andreessen and Ben Horowitz publicly endorse Donald Trump over Joe Biden, arguing that the current administration's hostile regulatory stance toward cryptocurrency, artificial intelligence, and venture capital threatens the future of American innovation and national security. The speakers contrast the Biden administration's restrictive executive orders and proposed unrealized capital gains taxes with Trump's platform promising to repeal these measures, defend self-custody rights, and accelerate technological competition against China. Citing the recent assassination attempt on Trump as a demonstration of the unique leadership required for this era, the venture capitalists conclude that the "little tech" ecosystem faces an existential crisis under current policies that necessitates a 180-degree strategic shift.
- Goldman Sachs28 min
A skeptical look at AI investment
Daron Acemoglu, Jim Covello, Alison Nathan
While Goldman Sachs projects generative AI could boost U.S. GDP by 6.1% over a decade, MIT's Darren Acemoglu and Goldman's Jim Covello warn that high infrastructure costs and technical limitations may restrict automation to less than 5% of tasks. Driven by fear of missing out in a competitive "arms race," major technology firms are currently pouring capital into GPU-heavy infrastructure despite the absence of a cost-effective "killer application," sparking concerns that the sector mirrors the overbuild of the 2000 internet bubble. Analysts emphasize that the next 12 to 18 months serve as a critical inflection point where the emergence of tangible business use cases will determine whether this trillion-dollar investment cycle results in sustained productivity gains or a sharp correction in valuations.
- Milken Institute30 min
A Conversation with Her Majesty Queen Rania Al Abdullah of Jordan | Global Conference 2024
Queen Rania Al Abdullah, Kevin Herglotz, Her Majesty Queen Rania Al Abdullah, Ali Velshi
Queen Rania addresses the global humanitarian crisis by warning that "us vs. them" polarization and unsustainable military operations in Rafah are driving toward large-scale civilian deaths and eroding prospects for peace. She rejects the narrative that the two-state solution is dead, instead attributing stagnation to a deficit of political will and explicitly condemning any forced transfer of Palestinians as a "second Nakba." Urging the United States to enforce international law rather than offering unconditional support, she argues that long-term Israeli security remains impossible without ending the illegal occupation and addressing the systematic injustices facing both populations.