Latest Interviews
Showing 991–1005 of 3,244 interview transcripts.
Clear all filters- a16z46 min
Hey Tech, Come to Healthcare
In a 2022 analysis, analysts BJ and Daisy predict that consumer health technology will produce the world's first trillion-dollar company by leveraging a $4 trillion U.S. market where 88% of the population faces metabolic challenges. The event details how artificial intelligence and post-pandemic cultural shifts are enabling a transition from reactive sick care to predictive, home-centric prevention while bypassing traditional incumbent barriers through new "payvider," marketplace, and financial infrastructure models. These strategies aim to unify fragmented health data and engineer behavioral change, ultimately positioning tech founders with hybrid clinical expertise to replace legacy systems with AI-driven, high-UX solutions.
- Goldman Sachs9 min
Why emerging markets could keep rallying
Stratford Dennis, Mike Washington
Goldman Sachs projects a 10% rally in MSCI Emerging Markets equities through year-end, driven by positive growth differentials, a weaker US dollar, and widespread institutional underweight positioning. Analysts favor "EM ex-China" strategies over Chinese assets while specifically highlighting Brazil as a high-conviction opportunity supported by attractive valuations and expected rate cuts. The firm recommends purchasing upside calls on dollar-denominated Brazilian indices to capitalize on this convergence, framing the broader shift toward emerging markets as a multi-year structural trade dependent on US bond market stability.
- Goldman Sachs30 min
Alnylam’s Yvonne Greenstreet on RNAi and a ‘golden era’ in biotech
Alnylam Pharmaceuticals leverages a decade of RNA interference research to achieve a 55% clinical success rate and recently secured approval for Amvutra to treat hereditary transthyretin-mediated amyloidosis. Under CEO Yvonne Greenstreet, the company aims to become a top-five biotech leader by 2026 through a five-year strategy to deliver 25 clinical programs and expand into common diseases like hypertension. To reach this goal, Alnylam integrates AI-driven drug design with a culture of diversity and patient advocacy to de-risk development and target tissues beyond the liver, including the central nervous system.
- All-In Podcast25 min
Nico Rosberg on the Booming Business of F1 | All-In Live from Miami
Nico Rosberg, Chamath, Jason, Friedberg
Former 2016 Formula 1 World Champion Nico Rosberg detailed his strategic pivot from racing to venture capital, highlighting significant portfolio investments in AI and software while cautioning against the complexities of the European hardware market. The discussion further analyzed the sport's evolution, noting how rigorous safety innovations and a $130 million budget cap have transformed F1 into a highly profitable enterprise with valuations reaching $6 billion per team. Rosberg emphasized that the sport's recent success stems from a blend of advanced driver training, a Netflix-driven demographic expansion, and the unique convergence of traditional sports with the digital finance ecosystem.
- a16z1h 45m
Beyond Leaderboards: LMArena’s Mission to Make AI Reliable
Anjney Midha, Anastasios N. Angelopoulos, Wei-Lin Chiang, Ion Stoica
LM Arena has transformed from a static benchmark into a dynamic "humanity's exam" that evaluates over 280 AI models through real-time feedback from one million monthly users, effectively eliminating data contamination through fresh prompt generation. By treating evaluation as Reinforcement Learning rather than Supervised Learning, the platform utilizes techniques like "style control" and the open-sourced "Prompt-to-Leaderboard" router to achieve twice the performance-per-cost while maintaining academic neutrality. Looking forward, the organization plans to expand into private industry-specific Arenas and multi-modal agent testing while remaining committed to open-sourcing all data and research to preserve ecosystem trust.
- The Diary Of A CEO1h 31m
The Foot Expert: Your Toes Can Predict If You’ll Die Early! This Will Fix Plantar Fasciitis!
Dr. Courtney Conley and host Stephen Bartlett examine the critical link between foot health, longevity, and mental well-being, highlighting how modern footwear compromises natural mechanics to cause widespread mobility issues. The discussion details how narrow, cushioned shoes exacerbate conditions like plantar fasciitis and depression, while prescribing a transition to zero-drop footwear and specific strength exercises to restore intrinsic muscle function. By addressing root causes such as overstriding and weak musculature, the speakers advocate for a functional approach that reduces cardiovascular and mortality risks while empowering individuals to maintain movement as a fundamental mode of survival.
- Milken Institute21 min
A Conversation with Eric Schmidt | Global Conference 2025
Eric Schmidt analyzes the evolving Ukraine conflict as a volatile stalemate driven by massive drone production, automated sensor-to-shooter loops, and the obsolescence of traditional armored platforms like tanks and aircraft carriers. He contrasts Ukraine's rapid, two-week innovation cycles against the Pentagon's sluggish 16-year procurement process, arguing that rigid bureaucratic structures prevent the U.S. from adopting necessary autonomous systems. Schmidt concludes that to counter modern hypersonic threats and future high-intensity warfare, the U.S. must pivot from expensive stationary assets to affordable, internet-prosecuted robotic forces integrated with its domestic startup ecosystem.
- Jane Street1h 20m
Building Tools for Traders with Ian Henry
Ian Henry, Ron Minsky, Mark Mandelbaum, Mark Mirchandani, David Eastman, Brian Dorsey
Ian Henry, a Jane Street engineer who transitioned from general web development to options trading tools, leverages the firm's custom OCaml ecosystem to build high-density interfaces that eliminate mouse usage and manage complex volatility surfaces. His recent work includes creating Bauble, a live 3D graphics environment in the Janet language that demonstrates how side projects using image-based state serialization and novel macro systems can rapidly inform internal production tooling. Through this process, Henry illustrates how Jane Street bridges the gap between low-latency exchange architecture and expert user needs by prioritizing type safety, extreme information density, and a parallel software universe free from standard web protocols.
How Wander Raised Over $100M+ to Reinvent Luxury Travel
Wander, a verticalized vacation rental marketplace led by founder John Andrew, recently secured a Series B term sheet with QED to scale its curated inventory of top-tier properties beyond 1,000 locations. The company differentiates itself through a proprietary AI-driven operating system that automates 60% of management tasks and maintains strict brand safety standards while transitioning from an asset-heavy balance sheet to a REIT-based model. With a $40 million GMV run rate and a $100 million annual revenue target, Wander is restructuring into business units to support efficient growth toward Series C while prioritizing operational frugality and ethical cultural fit.
- a16z1h 18m
Rick Rubin: Vibe Coding is the Punk Rock of Software
Rick Rubin, Marc Andreessen, Ben Horowitz, Anjney Midha, Erik Torenberg
Rick Rubin introduces "vibe coding" as a methodology merging the ancient spiritual principles of the Tao Te Ching with modern AI to democratize creation for non-technical users. The discussion outlines how this approach treats AI as a tool for human expression rather than an autonomous creator, aiming to counteract the homogenization of global culture and narrow demographic biases in current tech development. Ultimately, the event advocates for a future of education focused on cultivating taste and self-knowledge, allowing artists to leverage AI to raise creative ceilings while maintaining authentic individual agency.
- a16z21 min
7 More Healthy Years: What We Can Learn from Super Agers
The proposed healthcare strategy shifts focus from unproven aging reversal to preventing the "big three" age-related diseases through modifiable lifestyle factors and emerging medical technologies. By integrating personalized omics data, AI-driven risk profiling, and novel treatments like GLP-1 drugs and cellular therapies, this approach aims to extend healthspan by seven years for populations globally. This evidence-based framework prioritizes immediate disease mitigation over theoretical longevity, leveraging a 20-year incubation window to fundamentally redefine the standard of care.
- Goldman Sachs24 min
How AI, tariffs, and the energy transition are reshaping infrastructure investing
Large institutional investors have allocated 6% to 7% of assets to infrastructure, a sector that generated nine percent returns since 2022 while evolving from traditional transport dominance to focus on energy transition and digital assets like AI-driven data centers. Goldman Sachs identifies key opportunities across four segments, noting that solar plus storage is now cost-competitive and that European markets are gaining traction due to Germany's massive infrastructure plan, despite geopolitical and liquidity risks in specialized areas. To capitalize on these secular trends in decarbonization and digitalization, investors utilize closed-ended funds targeting mid-teens returns or evergreen vehicles for long-term capital appreciation.
- Sequoia Capital38 min
From Data Centers to Dyson Spheres: P-1 AI's Path to Hardware Engineering AGI
Paul Eremenko, Sonya Huang, Pat Grady
P1.ai is launching its AI engineering agent "Archie," which addresses the scarcity of physical design data by synthesizing massive, physics-informed datasets to train specialized models for hardware creation. Initially targeting data center cooling applications in 2025, the system operates as a collaborative team member that orchestrates existing CAD and simulation tools to perform complex design synthesis and error correction at entry-level engineer proficiency. With angel investment from Jeff Dean, the company aims to scale the agent's capabilities from residential cooling to aerospace domains over the next four years, ultimately striving for Engineering AGI defined by self-reflection and domain generalization.
- All-In Podcast1h 2m
Senator Ron Johnson on the Senate showdown over Trump's Big Beautiful Bill | All-In Interview
Ron Johnson, Trump, Friedberg, Chamath, Jason
Senator Mike Johnson warns that projecting federal spending to reach $7.3 trillion annually could swell the national debt to $63 trillion by 2035, a trajectory he argues the current House reconciliation bill fails to address. While acknowledging the limitations of budget reconciliation, he vows to vote against the legislation unless it commits to returning spending to pre-pandemic levels and codifies efficiency findings through rescission rather than broad political packages. Joined by allies like Senators Rand Paul and Mike Lee, Johnson insists that without immediate corrective measures to curb interest costs and discretionary spending, the United States risks a debt spiral that would fundamentally erode the conservative movement and the economy.
- a16z16 min
Sovereign AI: Why Nations Are Building Their Own Models
Anjney Midha, Guido Appenzeller
Saudi Arabia has announced the construction of a $100 billion to $250 billion local hyperscaler named "Humane" to establish sovereign AI infrastructure capable of running 500-megawatt clusters that prioritize national control over cultural and informational output. This strategic pivot distinguishes itself from traditional cloud computing by treating AI as a critical cultural asset, requiring nations to build independent "AI Factories" to prevent foreign entities from dictating model values and societal narratives. The resulting geopolitical landscape favors a competitive market ecosystem where nations secure their own inference capabilities, potentially avoiding total centralization while mitigating risks associated with reliance on foreign foundation models.