Latest Interviews

E113: DOJ tries to break up Google, vaccine questions, Ukraine escalation & more

David Sacks

The U.S. Department of Justice and eight states filed an antitrust lawsuit against Google alleging monopolistic control over digital ad brokering, a move panelists argued would stifle innovation by unwinding the 2008 DoubleClick acquisition. Simultaneously, European regulators probe Microsoft for anti-competitive bundling of Teams with Office, while the panel critiqued the rapid, EUA-bypassed rollout of mRNA vaccines and warned of geopolitical escalation risks in Ukraine that could trigger nuclear confrontation. In a shift toward scientific innovation, researchers demonstrated the reversal of aging in mice by correcting epigenetic degradation, a breakthrough that is prompting investors to target companies developing targeted transcription factor therapies.

The Mindset Doctor: The Secret Man Behind The World's Top Performers | Professor Steve Peters

Professor Steve Peters, Steve Peters

Psychologist Steve Peters presents a three-system mental model distinguishing the rational "Human," the emotional "Chimp," and the automated "Computer" to explain how beliefs, trauma, and habits shape behavior. The framework advocates managing unhelpful emotional impulses through evidence-based reprogramming and commitment rather than relying on fluctuating motivation, as demonstrated by the case of snooker champion Ronnie O'Sullivan overcoming his freeze response. Ultimately, Peters urges individuals to define their core identity separate from these internal systems to achieve stability in relationships, professional performance, and personal growth.

E112: Is Davos a grift? Plus: globalist mishaps, debt ceilings, TikTok's endgame & more

Calacanis, Friedberg, David Sacks, Chamath Palihapitiya

Moderated by Jake Calacanis, David Sacks, and their fellow panelists debate the podcast's origins while analyzing the 2024 presidential landscape, specifically evaluating the strengths of Donald Trump, Ron DeSantis, Nikki Haley, and Glenn Youngkin against a backdrop of voter concerns over fiscal responsibility. The hosts further dissect global economic tensions by critiquing the World Economic Forum, arguing for deglobalization strategies to counter China's energy and industrial dominance, and advocating for a points-based immigration system to attract high-value talent. Finally, the group addresses specific security risks posed by TikTok, the transformative potential of AI in biotech, and the legal liability surrounding the *Rust* shooting tragedy before concluding with insights into emerging aging research.

E111: Microsoft to invest $10B in OpenAI, generative AI hype, America's over-classification problem

Hosts Jason Calacanis and David Sacks critique the erosion of journalistic neutrality, San Francisco's homelessness policy failures, and the manipulation of ESG financial instruments as tools to mask debt. The discussion shifts to the artificial intelligence sector, detailing Microsoft's strategic investment in OpenAI and urging entrepreneurs to secure proprietary data moats against potential copyright litigation. Finally, the conversation examines the political implications of classified document scandals surrounding current and former presidents, questioning how such investigations reinforce a permanent government while deterring qualified business leaders from public service.

Derren Brown: UNLOCK The Secret Power Of Your Mind! | E212

Derren Brown, Dan

In his live show "Showman," Darren Brown explores the psychological necessity of suffering and anxiety as catalysts for growth, utilizing audience interaction to demonstrate how shared isolation fosters connection. Drawing on his personal journey from a shame-driven magician to a public figure who came out in his late thirties, Brown critiques modern self-help narratives that blame individuals for uncontrollable outcomes while advocating for a Stoic framework that distinguishes between internal agency and external fortune. Through this synthesis of magic, hypnosis, and personal revelation, the event challenges audiences to abandon the pursuit of a problem-free life in favor of finding meaning within the present moment and embracing the complexity of human vulnerability.

Lars Doucet — Progress, poverty, Georgism, & why rent is too damn high

Lars Doucet, Sam Altman, Vitalik Buterin, Scott Alexander, Noah Smith

Author Lars Ducey advocates for the Land Value Tax as a mechanism to resolve economic inequality by capturing unearned land rent while incentivizing productive labor and capital development. His proposed transition strategies, supported by his startup Geoland Solutions, aim to replace regressive income taxes with a split-rate system that generates trillions in revenue for public services and a universal citizen dividend. The framework extends beyond physical geography to address digital assets and virtual real estate, arguing that these modern scarcity points require similar taxation to prevent monopolization and ensure fair access.

Feeling Lost? Neuroscience Explains Why! The Science Behind Happiness! - Dr Tali Sharot

Dr Tali Sharot, Tom

This analysis synthesizes Tali Sherrat's research on the U-shaped trajectory of happiness across the lifespan and its profound correlation with economic outcomes, noting that optimism drives significant salary increases and entrepreneurial success through self-fulfilling psychological mechanisms. The findings detail how brain adaptation and confirmation bias influence decision-making, often trapping individuals in certain misery, while strategies like granting agency and introducing novelty offer effective pathways to improve well-being and relationship satisfaction. Ultimately, these insights advocate for managing risk perception and leveraging emotional contagion to navigate life transitions, suggesting that controlled optimism serves as a vital tool for both personal resilience and professional advancement.

E110: 2023 Bestie Predictions!

Chamath, Calacanis, Friedberg, David Sacks

David Sacks, Chamath Palihapitiya, and David Freiberg forecast major geopolitical shifts, predicting that Saudi Arabia's Mohammed bin Salman will gain global influence through a Petro-Yuan alliance while the US dollar loses its status as a risk-free asset. In the technology and business sectors, the speakers identify Relativity Space and OpenAI as top winners alongside a predicted purge of capital-intensive growth startups and a decline in Google Search usage due to AI integration. The panel also anticipates specific market corrections, including a collapse in San Francisco commercial real estate values, a surge in junk debt defaults, and significant consolidation in the gig economy and healthcare sectors.

Davina McCall: How To Overcome ANY Trauma & Live The Life You Deserve | E210

Davina McCall, Steven Bartlett

Television presenter Davina McColl recounts her journey from a childhood marked by maternal abandonment and early substance abuse to achieving sobriety through Narcotics Anonymous and securing a career at MTV Europe. Her personal evolution was further catalyzed by the grief following her sister Caroline's death and her advocacy for destigmatizing menopause in her book *Menopausing*, which challenges medical misconceptions and promotes Hormone Replacement Therapy. Today, at age 55, McColl leverages her platform to encourage authentic self-expression, reject cancel culture, and support others navigating similar psychological and physiological challenges through her evolved "second spring."

Holden Karnofsky — History's most important century

Holden Karnofsky

GiveWell co-founder Holden Karnofsky argues that this century represents the most significant in human history due to the high probability of developing transformative AI capable of compressing thousands of years of progress into a short timeframe. He asserts that while such a shift offers the potential for a post-scarcity future, it carries the risk of creating a dystopian lock-in if AI systems remain misaligned with human moral frameworks. Consequently, Karnofsky's organization, Open Philanthropy, now prioritizes funding AI alignment research and speculative long-term work to navigate these unprecedented stakes while maintaining ethical rigor.

Doctor Tim Spector: The Shocking New Truth About Weight Loss, Calories & Diets | E209

Tim Spector OBE

Professor Tim Spector argues that individualized nutrition based on gut microbiome diversity and food quality is superior to ineffective calorie counting or generic diet trends for sustainable weight loss and disease prevention. His research highlights that ultra-processed foods and artificial sweeteners disrupt metabolic signals while personalized dietary interventions, such as consuming 30 weekly plant types and practicing time-restricted eating, can improve mood, inflammation, and longevity. Leveraging data from 50,000 participants through his company Zoe, Spector advocates for replacing restrictive crash diets with a varied, whole-food approach that prioritizes biological individuality over corporate-backed "one size fits all" guidelines.

E109: 2022 Bestie Awards Live from Twitter HQ

Calacanis, Rudy Giuliani, Shellenberger, David Sacks, David Friedberg, Chamath Palihapitiya, Elon Musk

The All-In podcast team convened in Lake Tahoe in December 2022 to present their annual Bestie Awards, during which Jay Cal was unanimously voted the new Director of the All In Summit. The episode featured extensive analysis of 2022 political winners like Ron DeSantis and Xi Jinping, business shifts involving defense stocks and generative AI, and critical discussions with Elon Musk regarding his Twitter acquisition. Additional guests included Michael Schellenberger, who detailed FBI influence on content moderation, while the panel also recognized top investors, identified worst performers, and selected the year's most significant scientific breakthroughs.

Jamie Carragher: The Untold Story of Liverpool Legend That Pushed Himself Too Far | E206

Jamie Carragher, Gérard Houllier, Ronaldo

Former Liverpool defender Jamie Carragher reflects on a career defined by a father-induced zero-tolerance for weakness and his own psychological struggle with imposter syndrome, detailing how he managed intense self-imposed pressure through sports psychology. He contrasts the leadership styles of Gérard Houllier, Rafa Benítez, and Sir Alex Ferguson while explaining how a collective belief turned the 2005 Champions League final from a likely massacre into a victory. Ultimately, Carragher argues that his longevity stemmed from viewing every obstacle as a challenge to overcome, while acknowledging that his sharp, unromantic demeanor may hinder his future as a football manager despite his analytical expertise.

Neil deGrasse Tyson: Do THIS Every Morning To Find Happiness & Meaning In Your Life!

Neil deGrasse Tyson, Jack

Astrophysicist Neil Tyson engages audiences with accessible storytelling techniques that bridge complex scientific concepts and pop culture while advocating for objective truth as an antidote to societal polarization. Drawing on a childhood marked by strategic parental guidance and a segregated-era father's resilience, he critiques binary thinking and promotes the scientific method as a necessary framework for public policy and personal growth. Tyson further explores profound philosophical themes regarding mortality and meaning, predicting a future where humanity achieves "escape velocity from death" by balancing rational inquiry with emotional intelligence.

Billy McFarland: The Man Behind The Infamous Fyre Festival Disaster | E202

Billy McFarland, Andy king, Ja rule

Billy McFarland, the architect of the fraudulent Fyre Festival who defrauded investors of over $26 million with fake accommodations and false projections, was sentenced to six years in prison and now faces lifetime restitution and an SEC ban on public company leadership. Following his release, McFarland is navigating strict probation while managing severe psychological trauma from ten months of solitary confinement and attempting to rebuild his reputation through a new, small-scale experiential venture called Pirate. His ongoing efforts focus on repaying defrauded investors and avoiding the impulsive behaviors that previously led to the festival's catastrophic collapse, even as he remains banned from returning to the Bahamas where the original event took place.