Latest Interviews

I Tested 100,000 People's DNA. This Diet Will Kill You - Gary Brecka

Gary Brecka

Former life insurer Dr. Gary Brekka is leveraging his actuarial background to reframe chronic disease as a consequence of internal nutrient deficiencies and genetic methylation errors rather than external pathology. His approach integrates specific biomarkers, genetic testing for mutations like MTHFR, and daily rituals including grounding and sunlight exposure to address root causes of conditions ranging from anxiety to hypertension. Brekka aims to transition from treating symptoms with pharmaceuticals to empowering a network of professionals who can utilize preventative data to correct underlying metabolic failures and extend human longevity.

Embracing American Dynamism to Upgrade Manufacturing Production With Oden CEO Willem Sundblad

Willem Sundblad, Molly O'Shea

Odin Technologies secured a $28.5 million Series B investment led by Sweden's North Star Growth, with participation from Flat Capital and current customers to accelerate the deployment of its real-time Process AI platform. The company targets large-scale manufacturing operations in sectors like paper, pulp, and plastics, where its interpretability-focused technology reduces operator dependency and shortens sales cycles by half. Following over three times growth since 2022, the capital will fund the integration of domain-specific foundation models and data enrichment tools to expand operations from North America into Europe and Latin America.

Mark Zuckerberg — Llama 3, $10B models, Caesar Augustus, & 1 GW datacenters

Mark Zuckerberg, Caesar Augustus

Meta has launched its open-source Llama 3 family, featuring 8 billion and 70 billion parameter models that compete with leading benchmarks, while simultaneously integrating the new Meta AI assistant across Facebook, Instagram, WhatsApp, and Messenger. To support these capabilities and future multi-agent applications, the company is rapidly expanding its hardware infrastructure to 350,000 GPUs and developing custom silicon to overcome energy and permitting bottlenecks. Founder Mark Zuckerberg emphasizes a strategic commitment to open distribution to mitigate concentrated AI risks, framing these technological shifts as fundamental changes to global productivity comparable to the invention of computing.

Jocko Willink (Former Navy Seal): Use This Weird Trick To Overcome Fear, Anxiety & Self-Doubt!

Jocko Willink, Dario Vecchio

This presentation by Willink distills leadership and resilience through Navy SEAL insights, emphasizing core tenets like extreme ownership, disciplined action, and the power of a defined purpose to navigate adversity. Drawing from personal history and training statistics, the discussion outlines a framework for building confidence through incremental wins and managing trauma by balancing emotional awareness with forward momentum. Ultimately, the session advocates for a lifestyle of non-negotiable discipline and collaborative planning to foster personal growth and effective leadership in high-stakes environments.

When Should You Trust Your Gut?

Dalton, Michael

Startup guidance at YC distinguishes between founders bringing deep prior expertise, who should trust their gut to build products that impress themselves, and those building expertise, who must rely on rapid learning and customer discovery to avoid over-planning. The most frequent failure mode involves role confusion where experts chase investor trends instead of leveraging their unique vision, or novices apply complex roadmaps without validating assumptions. Consequently, advisors are urged to tailor feedback dynamically, shifting from instinct-driven validation for experts to iterative market learning for generalists to align strategy with the founders' actual capabilities.

Jared Cohen on US leaders finding purpose post-presidency

Jared Cohen, John F.W. Rogers

Jared's new #9 New York Times bestseller analyzes the historical trajectories of post-presidencies through four distinct case studies, including William Howard Taft, Herbert Hoover, George W. Bush, and Grover Cleveland. By examining how these leaders successfully deferred ambitions, recovered from defeat, detached from former power, or faced the limitations of a political comeback, the work illustrates that the institution's resilience relies on evolving norms rather than constitutional text alone. The author argues that longevity and fulfillment in retirement require abandoning the vanity of office to pursue new service or hobbies, offering a framework for navigating life after the presidency regardless of political affiliation.

Are inflation fears overblown? The outlook for inflation, US growth, and long-term rates

David Mericle, Alison Nathan

Goldman Sachs projects U.S. GDP growth of 2.5% in 2024, driven by labor supply expansions from immigration that prevent overheating despite disinflation from shelter rents. The firm argues the neutral interest rate has structurally shifted to 3.0%–3.5%, forecasting Federal Reserve rate cuts beginning in July 2024 as financial conditions remain accommodative. This outlook suggests a balanced labor market and mechanical rent adjustments will allow inflation to trend toward 2.5% without triggering wage-price spirals.

Jimmy Carr: "There's A Crisis Going On With Men!"

Jimmy Carr, Dario Vecchio

Comedian and podcaster James Carr explores the psychological tensions between modern comfort and character development, arguing that a "No Man's Land" of deliberate struggle is essential for self-actualization and that imposter syndrome serves as a healthy signal of growth. He systematically analyzes professional strategy by applying specific cadence metrics to public speaking and defending comedy as a vital counter to social censorship, while simultaneously addressing mental health through the distinction between clinical depression and circumstantial sadness. Carr concludes by advocating for a shift from measurable career metrics to immeasurable life priorities, emphasizing that building resilience requires young people to embrace real-world risk and maintain strong social bonds amidst a culture of digital isolation.

E174: Inflation stays hot, AI disclosure bill, Drone warfare, defense startups & more

J-Cal, Jason, Biden, Zelenskiy, Chamath Palihapitiya, Dave Friedberg, Nick

Scheduled for September 8–10 in Los Angeles, the upcoming All-In Summit 2024 will feature a confirmed single-tier ticket structure while finalizing speaker announcements and leveraging the hosts' recent analysis of AI market shifts and global urban decay. During the event, speakers will debate critical macroeconomic pressures from persistent inflation and the structural challenges facing NVIDIA, alongside the geopolitical implications of autonomous drone warfare and new copyright legislation for generative AI. These discussions aim to synthesize complex industry dynamics, ranging from cloud computing ecosystems to the potential end of the declining interest rate era, providing attendees with a comprehensive outlook on emerging technological and financial landscapes.

Kyle Harrison, GP at Contrary on Techno-Optimism, Talent Vortexes, & Writing “Investing 101”

Kyle Harrison, Molly O'Shea

Kyle Harrison, a former film major who transitioned into venture capital through diverse roles at TCV, Coatue, and Index, now applies a holistic framework at Contrary to support talent from undergraduate studies through company exits. Contrary operates as a "talent vortex" that leverages a productized research arm and a generalist investment strategy across sectors like defense and AI to identify the "smartest people" early and facilitate career growth via its open-source reports. Harrison's approach emphasizes navigating geopolitical shifts and hype cycles by treating truth as a narrative construct while preparing for an upcoming age of acquisition driven by capital recycling and market correction.

Inside The Hard Tech Startups Turning Sci-Fi Into Reality

Y Combinator advises hard tech founders to leverage a $500,000 investment and three-month timeline to validate specific technical kernels rather than building full-scale complex products. By isolating manageable milestones—such as securing massive Letters of Intent or demonstrating proof-of-concept prototypes—companies like Boom Supersonic and Relativity Space de-risk their ventures to achieve billion-dollar valuations or successful commercial launches. This strategy prioritizes "timeline compression" and tangible execution over traditional fundraising, allowing teams to mitigate technical risks while capitalizing on obvious market demand.

Advancing Inclusion Through Leadership with Boston Athletic Association’s Dr. Cheri Blauwet

Dr. Cheri Blauwet, Dean Athanasia

Dr. Sherry Blauwet, a Paralympic medalist and former Boston Athletic Association chair, leads the Boston Marathon bombing anniversary's expanded mission to prioritize year-round community health through the newly established Kelly Adaptive Sports Research Institute. Her strategy reframes adaptive sports as a public health solution for over 25% of U.S. adults by leveraging corporate partnerships and a small grants program to support diverse physical activity needs. Blauwet drives this initiative by challenging societal lowered expectations and promoting leadership intentionality, aiming to transform public perception of disability while maintaining a focus on fun and accessibility for all age groups.

The Longevity Expert: Is There A Link Between Milk & Cancer? + Ozempic Can Really Mess You Up!

Dr Mark Hyman, Stephen

Mark Hyman and his Functional Medicine team at Function Health advocate for a root-cause approach to health that prioritizes personalized diagnostics and lifestyle interventions over symptomatic drug treatments like Ozempic. This philosophy emphasizes reversing chronic metabolic dysfunction by eliminating ultra-processed foods, optimizing protein intake, and addressing psychological trauma alongside environmental toxins known as the exposome. By leveraging AI to analyze over 100 biomarkers, the initiative aims to democratize elite-level health optimization while calling for systemic policy changes to reshape the toxic food environment driving 11 million annual deaths.

Global insurers turn to private credit — and AI

Mike Siegel, Matt Armas, Alison Nathan

The Goldman Sachs Insurance Survey, recorded on April 4, 2024, reveals that global insurers are reallocating $26 trillion in assets toward private credit and high-yield fixed income to counteract recession risks and declining interest rates. While the industry accelerates AI adoption to improve underwriting accuracy and drive consolidation, it simultaneously reduces commercial real estate exposure and pivots ESG strategies toward climate transition financing. These shifts reflect a strategic effort to balance portfolio resiliency against economic downturns with the operational efficiencies promised by new technology.

Ronda Rousey: I Kept This A Secret My Entire Career! WWE Is A Mess!

Ronda Rousey

Former judo champion and UFC fighter Rhonda Rousey discusses her traumatic early life, the normalization of abuse in combat sports, and the severe cumulative brain injuries that concealed her decline until her 2015 loss to Holly Holm. Following a crisis involving depression and suicidal ideation, she leverages her experience to critique the dangerous, unchecked power structures in the WWE while detailing her current life on an Oregon ranch dedicated to regenerative agriculture and creative writing. Rousey advocates for stricter regulatory oversight in athletics to prevent similar athlete exploitation and calls for a comprehensive overhaul of the professional wrestling industry's management culture.