Latest Interviews
Showing 2401–2415 of 9,648 transcripts.
Clear all filters- Goldman Sachs37 min
Nasdaq CEO Adena Friedman on the future of public markets
Adena Friedman, John Waldron, Allison
Led by CEO Adena Friedman, the NASDAQ has evolved from a US electronic stock exchange into a global technology platform supplying critical infrastructure to 130 markets while prioritizing liquidity, transparency, and anti-financial crime solutions. The organization recently navigated record trading volumes and leverages hybrid cloud architecture and generative AI to enhance market resilience, with a specific strategic focus on the anti-financial crime sector following the Verifin acquisition. Looking forward, leadership advocates for structural regulatory reforms to reverse the decline in public listings and attract capital back to public markets against the backdrop of rapid private market growth.
- The Diary Of A CEO1h 28m
Michelle Obama: This Is A Scam! People Were Running From Us Because We Were Black!
Michelle Obama, Steven, Craig Robinson, Barack Obama
Michelle and Craig Robinson's podcast explores their upbringing in Chicago, where their parents instilled resilience and advocacy through personal sacrifice and community leadership. The conversation details Michelle's pivotal career shift from corporate law to public service, influenced by personal tragedy and her relationship with Barack Obama, alongside the challenges of navigating the White House as the first Black First Lady. Concluding with their mother's recent passing, the siblings emphasize a legacy of mentorship, urging audiences to prioritize character, practice boundary-setting, and navigate adversity with empathy.
- a16z27 min
Biotech CEO on where we are in the fight to cure cancer
Former Halozyme CEO Jonathan Lim leverages his experience scaling biotech startups to lead Araska Therapeutics, a company targeting the historically undruggable RAS pathway with a pipeline including the pan-RAF inhibitor Naporafenib. Concurrently, his family office, City Hill Ventures, manages a diversified portfolio of life sciences assets and media projects that parallel the high-risk, high-reward dynamics of pharmaceutical development. Lim's strategy emphasizes capital preservation and the combination of novel molecular glues with standard therapies to drive long-term remission rates beyond current limits in pancreatic, lung, and colon cancers.
- Dwarkesh Patel1h 16m
Mark Zuckerberg — AI will write most Meta code in 18 months
Meta has officially launched four Llama 4 models, immediately releasing the efficient Scout and Maverick variants while developing a massive two-trillion parameter "Behemoth" to distill intelligence into smaller, consumer-ready agents. The company is shifting its evaluation metrics from external leaderboards to internal product performance, prioritizing low-latency, full-duplex voice interactions and AI-driven content that reacts dynamically to user input across its billion-person ecosystem. By leveraging internal coding agents to accelerate development and advocating for a dual ad-supported and premium business model, Meta aims to narrow the gap with closed-source competitors while navigating infrastructure bottlenecks that will constrain the pace of an anticipated intelligence explosion.
- a16z1h 31m
How Andreessen Horowitz Disrupted VC & What’s Coming Next
Marc Andreessen, Ben Horowitz, Erik Torenberg
Established in 2009 by Ben Horowitz and Marc Andreessen, Andreessen Horowitz (a16z) redefined venture capital by replacing the passive "Sushi Boat" model with an active, capital-intensive platform strategy designed to provide deep operational support for "Full Stack" companies across verticals like AI and crypto. This structural shift responded to an overfunded market and dysfunctional public exits, enabling the firm to scale from a traditional two-person partnership into a decentralized network of expert operators that rivals major tech giants in domain capability. By prioritizing founder success over secrecy and leveraging a media-centric branding approach, a16z has transformed the VC asset class into a mechanism that fuels a wider pool of ambitious entrepreneurs despite the enduring unpredictability of human judgment in project selection.
- Goldman Sachs14 min
How AI and geopolitics are reshaping cybersecurity
Driven by escalating cyber threats and the strategic necessity for platform consolidation, the cybersecurity sector has witnessed record-breaking M&A activity despite a soft overall market, highlighted by Google's $32 billion acquisition of Wiz. While macroeconomic volatility creates near-term uncertainty for IPOs, the industry's resilient, "sticky" spending habits and significant private equity capital are redirecting focus toward cloud security and AI-driven defense solutions. This evolving landscape, bolstered by government partnerships and geopolitical tensions, positions the field as a critical competitive advantage even as it grapples with emerging risks from generative AI and autonomous attack vectors.
- Sequoia Capital56 min
The Quest to ‘Solve All Diseases’ with AI: Isomorphic Labs’ Max Jaderberg
Founded to construct a general AI-driven drug design engine, Isomorphic Labs has leveraged Demis Hassabis's Nobel Prize-winning leadership and Max Yoderberg's AI expertise to release AlphaFold 3, a diffusion-based model that predicts the 3D structures of proteins, DNA, RNA, and small molecules. By replacing months of traditional crystallization with instant in-silico analysis, the company collaborates with industry partners like Eli Lilly and Novartis to navigate the 10^60-sized chemical space and advance programs in oncology and immunology without operating its own wet labs. This approach positions AI as a fundamental, indispensable tool for the entire pharmaceutical industry within five years, while the firm advocates for new regulatory frameworks to validate these predictive models for clinical trials.
- a16z44 min
The Software Crisis Behind America's Infrastructure
Leila Hay, Phillip Buckendorf, Leonard J. Kosinski
ASI Co-founders Philip and retired General Leo Leo address the United States' critical software crisis by merging commercial aviation technology with Department of Defense logistics to replace fragmented legacy systems. Their strategy establishes a unified "collective logistics" framework that leverages AI-driven predictive capabilities to secure supply chains against cyber threats and geopolitical instability. By standardizing software stacks across the private and public sectors, the organization aims to rapidly modernize military infrastructure and maintain U.S. power projection capabilities by 2034.
Plural Partner, Taavet Hinrikus: Why Founders Will Realise Multi-Stage Funds Damage Seed Rounds
Taavet Hinrikus, Harry Stebbings
Venture capitalist Tal Talbot outlines Plural's strategic shift toward a low-fee, high-volume model that aligns incentives by charging half the industry standard management fee and requiring partners to personally back every investment. The firm targets deep hard-tech sectors like defense, fusion, and AI, explicitly rejecting saturated enterprise software markets to pursue 100x returns while advocating for European geopolitical sovereignty through government purchasing and unified capital mobilization. With Fund II expanding its reserve ratio to 50% and targeting companies such as Helsing and Proxima Fusion, Plural aims to rebuild Europe's critical industries amid a tri-polar global landscape where traditional VC metrics are declining.
- The Economist21 min
Modi behaviour: will India retaliate against Pakistan?
Narendra Modi, Rosie Bloor, Jason Palmer, Jeremy Page, Kerry and Richmond Jones, Daniel Knowles
Escalating India-Pakistan tensions have surged following a deadly 2024 attack in Kashmir, prompting New Delhi to suspend river treaties and mobilize forces while Islamabad threatens to withdraw from the Shimla Agreement. Analysts warn that high pressure for military retaliation, exacerbated by reduced US influence in the region, creates a significant risk of a broader conflict surpassing the 2019 crisis. Concurrently, domestic economic and technological dynamics persist, with religious institutions in Brazil expanding via tax incentives and global demand for magnetic tape storage surging for AI data archiving despite government claims of obsolescence.
- The Diary Of A CEO2h 14m
The Savings Expert: The Truth About America Collapsing! The Cost Of Living Is About To Skyrocket!
This discussion analyzes the volatile mechanics of current tariffs, the historical realities of global manufacturing specialization, and the role of artificial intelligence in accelerating economic disruption. It further outlines a philosophy of wealth creation centered on endurance, humility, and the strategic management of risk to achieve financial independence rather than status. The narrative concludes with actionable guidance for the next generation, emphasizing the development of interpersonal skills and the value of experiencing scarcity to foster resilience and long-term contentment.
- All-In Podcast1h 30m
Trump Rally or Bessent Put? Elon Back at Tesla, Google's Gemini Problem, China's Thorium Discovery
Trump, Bessent, Elon, Andrew Ross Sorkin, Chamath, Jason, Friedberg
A panel of experts analyzes global market dynamics, noting that recent rallies stem from trade deal expectations rather than Federal Reserve support, while highlighting strategic tensions over China's control of rare earths and its lead in thorium energy research. The discussion extends to foreign policy, where participants advocate for accepting the Istanbul Deal to end the Ukraine war and criticizing the moralistic approach to nation-building. Finally, the group evaluates corporate strategies for Alphabet and Tesla, the fiscal hurdles facing the Department of Government Efficiency, and the regulatory complexities surrounding Nvidia's global supply chain.
- Goldman Sachs9 min
“The most attractive hedge”
Goldman Sachs and global investors are reassessing the U.S. dollar following a 10% pre-inauguration depreciation driven by downward real GDP revisions from 2.5% to 1.3% and a widening growth gap against Europe. Analysts predict a multi-month reversal of long-dollar positions as fair value models show the currency remains 10% to 15% overvalued, with the short dollar/yen trade emerging as a primary catalyst contingent on tariff policy and Federal Reserve reaction functions. While immediate directional positioning is advised against pending clearer White House news and data releases, the structural shift suggests accelerated market moves within the next two to three months.
- Y Combinator17 min
How To Get The Most Out Of Vibe Coding | Startup School
The session establishes "vibe coding" as a disciplined engineering practice, recommending specific tool strategies such as using Replit for novices and dual-workflow setups with Cursor and Windsurf for experienced developers. It outlines a rigorous methodology involving architectural planning, modular Git-based implementation, and strict error handling protocols to manage AI-generated code effectively. The discussion further analyzes current model capabilities, highlighting Claude Sonnet 3.7 for implementation and Gemini for planning, while noting expected performance shifts due to training data biases in frameworks like Ruby on Rails.
- The Economist26 min
Carney score: last days of Canada’s campaign
Rosie Bloor, Jason Palmer, Sarah Larniuk, Noah Snyder, Fraser McGilraith
Hosted by Rosie Bloor and Jason Palmer, this broadcast examines Canada's volatile election driven by US protectionism concerns, media fragmentation, and a toxic political climate where Conservative leader Pierre Poilievé leverages social media to bypass traditional journalism. The program simultaneously analyzes the United States' critical shipbuilding deficit relative to Chinese and South Korean capacity, highlighting legal barriers to international co-production and the strategic choice between domestic revitalization or foreign reliance. Concluding with a 1945 archival perspective, the episode reflects on the human cost of Berlin's fall and the geopolitical complexities that followed the Allied victory over the Third Reich.