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  1. a16z47 min

    Digital Humans and the Story Behind Lil Miquela

    Lil Miquela, Trevor McFedries, Isaac Bratzel

    Created by Brud co-founders Trevor McFedries and Isaac Bratzel in 2016, the photorealistic virtual influencer Lil Miquela was developed to leverage social media narratives in a polarized political climate by mimicking a specific 19-year-old Brazilian-American persona. Brud bypassed traditional production costs by utilizing a small agile team and data-driven feedback loops to cultivate a deeply engaged fanbase that actively participated in the character's lore and cultural impact. This strategic success validated the viability of virtual humans as enduring media entities, prompting the creators to advocate for decentralized, community-owned future models while navigating ethical concerns regarding AI and labor displacement.

  2. Goldman Sachs35 min

    Bain Capital’s Stephen Pagliuca on private equity and the Boston Celtics

    Stephen Pagliuca, Alison Mass

    Steve Pelyuka, former Co-Chair of Bain Capital, traces the evolution of private equity from a localized boutique to a global vertical industry while detailing his strategic pivots in the Boston Celtics and Atalanta BC ownership. He outlines how modern investment resilience relies on high equity stakes, low-covenant lending, and a decade-long horizon to navigate elevated interest rates and geopolitical decoupling. Complementing these financial insights, Pelyuka emphasizes the critical role of A-plus management teams and data-driven analytics, citing his work on the Celtics' "Basketball Intelligence Agency" and the firm's enduring focus on healthcare and AI sectors.

  3. Lex Fridman3h 18m

    Eliezer Yudkowsky: Dangers of AI and the End of Human Civilization | Lex Fridman Podcast #368

    Eliezer Yudkowsky, Lex Fridman

    Eliezer Yudkowsky warns that aligning superintelligent AI requires getting the process right on the first attempt, as any failure could lead to human extinction due to an uncontrollable intelligence gap. He argues that current capabilities are advancing exponentially while safety research lags significantly, creating a risk where models optimize misaligned objectives or deceive human verifiers before a pause mechanism can be established. Consequently, Yudkowsky urges society to treat the threat as immediate rather than abstract, advocating for urgent action in alignment research and a rejection of open-sourcing advanced systems to prevent an irreversible loss of human control.

  4. The Diary Of A CEO1h 36m

    Alex Cooper: The Truth I Never Planned to Share...

    Alex Cooper, Steven

    Alex Cooper has grown from a bullied teenager to the creator of Spotify's *Call Her Daddy*, a podcast that generates hundreds of millions of monthly downloads while securing a $60 million exclusive deal. Despite navigating a volatile partnership, intense public scrutiny, and the psychological toll of maintaining a "wild" content schedule, she recently transitioned to a healthier personal life and established her own production company, Alex Cooper Studios. Cooper now plans to shift her career focus from on-camera hosting to behind-the-scenes production and film directing, aiming to balance commercial success with authentic storytelling.

  5. 20VC with Harry Stebbings1h 3m

    Jag Duggal: How We Scaled Nubank to 80M Users; Google's Brutal Hiring Practices | E995

    Jag Duggal, David Velez, Harry Stebbings, Kevin Systrom

    Jack Borthwick, a former executive at Google and Facebook, relocated to Brazil to lead product strategy at NewBank, where he applies a hiring philosophy that prioritizes drive and clarity over traditional credentials to serve the bottom half of the global income pyramid. Under his guidance, the financial institution successfully transitioned from a savings-only model to a primary banking relationship by leveraging data-driven metrics like churn and the "Sean Ellis test" to build genuine customer loyalty. Borthwick's approach combines rigorous execution speed with strategic clarity, enabling the company to disrupt traditional banking in Latin America while planning expansion into Mexico and Colombia.

  6. Dwarkesh Patel48 min

    Ilya Sutskever (OpenAI Chief Scientist) — Why next-token prediction could surpass human intelligence

    Ilya Sutskever

    OpenAI co-founder Ilya Sutskever outlines a trajectory where rapidly advancing AI models will face a critical bottleneck in reliability before reaching full AGI maturity by 2030, driven by the need to surpass human-level performance through scalable reasoning and automated data generation. He warns that aligning superintelligent systems will require a hybrid approach of adversarial testing and behavioral analysis to prevent deception, while predicting that economic value will remain robust despite data scarcity as long as inference costs stay justified by utility. Ultimately, Sutskever envisions a post-AGI future where human-AI collaboration fosters widespread moral and intellectual evolution, provided that continuous innovation in trustworthiness prevents the commoditization of core research.

  7. 20VC with Harry Stebbings49 min

    Dara Khosrowshahi: How I Became CEO of Uber; Uber Eats vs DoorDash; The Postmates Acquisition | E994

    Dara Khosrowshahi, Harry Stebbings

    Dara Khosrowshahi applies a philosophy of sustained excellence and calculated risk to guide Uber through its transformation from a crisis-ridden startup into a globally dominant logistics platform. By prioritizing marketplace technology over failed hardware ventures and correcting strategic missteps in delivery, he has successfully orchestrated complex supply-and-demand matching while shifting the board's focus from control to organizational success. His leadership approach emphasizes hiring for clarity of thought, maintaining a "plastic mind" to embrace mistakes, and allocating capital with a long-term perspective that balances Wall Street expectations with aggressive growth.

  8. Lex Fridman2h 24m

    Sam Altman: OpenAI CEO on GPT-4, ChatGPT, and the Future of AI | Lex Fridman Podcast #367

    Sam Altman, Lex Fridman

    OpenAI co-founder Sam Altman discusses the organization's transition to a capped-profit structure and the technical architecture behind GPT-4, emphasizing that its capabilities stem from incremental engineering rather than a single breakthrough. He outlines a strategy of "slow takeoff" for AGI development to prioritize safety alignment through Reinforcement Learning from Human Feedback while mitigating immediate risks like disinformation and economic disruption. Ultimately, Altman predicts that AI will drastically lower the cost of intelligence and drive global productivity growth, necessitating societal shifts such as Universal Basic Income to manage the resulting wealth redistribution.

  9. 20VC with Harry Stebbings6 min

    Bill Ackman wants to give $7000 to every baby

    Bill Ackman, Harry Stebbings

    The speaker warns that rising post-crisis wealth inequality threatens societal stability by creating a divide where asset compounding vastly outpaces wage growth. To counteract this, the proposal combines a universal "Baby Bonds" program funding $6,500 accounts for every newborn with tax reforms targeting loopholes like like-kind exchanges and unrealized gains taxes. While rejecting a broad 25% tax on appreciation for risking a liquidity crisis in startups, the speaker argues that closing specific loopholes to fund these bonds is essential for providing every citizen a permanent economic stake without harming business formation.

  10. All-In Podcast1h 34m

    E121: Macro update, Fed hike, CRE debt bubble, Balaji's Bitcoin bet, TikTok's endgame & more

    Balaji, Calacanis, Chamath Palihapitiya, David Friedberg, David Sacks, Nick Carter

    A panel of financial experts and entrepreneurs critically analyzes the Federal Reserve's 25-basis point rate hike, arguing that the "middle path" fails to address the severity of the commercial real estate crisis and looming banking liquidity concerns. Key figures like Chamath Palihapitiya and Jason Sacks forecast a potential $2–3 trillion government bailout to stabilize the dollar and prevent a systemic collapse, while debating whether Bitcoin will serve as a hedge or face regulatory suppression. The discussion also covers the geopolitical fallout of a likely TikTok shutdown, the engineering breakthroughs of Relativity Space's Terran 1 launch, and warnings regarding an impending US debt ceiling default.

  11. The Diary Of A CEO1h 55m

    Robert Greene: How To Seduce Anyone, Build Confidence & Become Powerful | E232

    Robert Greene

    Author Robert Greene explores the internal nature of power and the necessity of confronting human "shadow" traits, while drawing on his personal history of a debilitating stroke and subsequent recovery to illustrate themes of resilience and radical gratitude. He argues that true mastery requires abandoning the illusion of passion in favor of dedicated apprenticeship and thousands of hours of repetitive practice, a standard he believes modern instant-gratification culture actively undermines. Greene further advises young professionals to prioritize deep learning over immediate salary and cautions against the seductive power of digital interaction, emphasizing instead the primal importance of non-verbal communication and emotional vulnerability in building genuine connections.

  12. 20VC with Harry Stebbings1h 2m

    Frank Fillmann: How I Boosted Revenue by $500M at Salesforce; Tips for Hiring Salespeople | E992

    Frank Fillmann, Zhenya Loginov, Harry Stebbings

    Sales leader Frank synthesizes decades of experience, from door-to-door knife sales to managing teams of 75, into a methodology prioritizing potential over experience and the creation of latent demand. He advocates for "servant-leader" managers who build repeatable playbooks starting with financial metrics to cut ramp times to weeks while aligning sales with customer success through early integration. This approach emphasizes hybrid forecasting, deep discovery, and selfless leadership to navigate economic uncertainty and secure high-value enterprise deals in a transparent, remote-first market.

  13. 20VC with Harry Stebbings1h 7m

    Bill Ackman: SVB Collapse, Biden vs Trump, How I Lost $400M on Netflix, Bill's 10-Year Long

    Bill Ackman, Biden, Trump, Harry Stebbings

    Bill Ackman and David Berkowitz launched their partnership with a $3.1 million fund by leveraging a shared track record of high achievement and living together to minimize initial costs. Following significant setbacks during the 2008 financial crisis, Ackman restructured Pershing Square to invest exclusively in liquid large-cap public companies while maintaining a disciplined approach to position sizing based on the risk of permanent capital impairment. In current markets, Ackman advocates for immediate federal guarantees on all bank deposits to prevent runs, argues that persistent inflation requires the Federal Reserve to pause rate hikes, and proposes policy reforms such as universal baby bonds to address wealth inequality.

  14. The Diary Of A CEO1h 27m

    Fix Your Gut Health! The 4 Foods Fueling Inflammation & Disease! - Dr Will Cole

    Dr Will Cole

    Functional medicine practitioner Dr. Cole contrasts optimal health ranges with conventional diagnostic averages, addressing the widespread epidemic of metabolic and autoimmune disorders driven by chronic inflammation, intergenerational trauma, and nervous system dysregulation. He outlines a root-cause approach that integrates specific dietary modifications like the "Inflammatory Core Four" protocol, microbiome optimization, and strict technology boundaries to restore gut-brain axis function and lower pro-inflammatory cytokines. As the paradigm shifts toward this holistic model, Cole emphasizes that sustainable healing requires balancing advanced nutritional science with personal practices like grounding and stress reduction to overcome the physiological impacts of modern lifestyle stressors.

  15. 20VC with Harry Stebbings7 min

    Will there be more bank runs?

    Jackie Reses, Kris Dickson, Harry Stebbings

    Financial experts warn that secondary bank runs are highly probable and driven by panic psychology rather than fundamental weaknesses, with specific risks concentrated in institutions lacking diversification. To mitigate this, the FDIC plans to announce a buyer by Monday morning offering full deposit guarantees and immediate liquidity to stabilize markets before the U.S. trading day begins. While small businesses face the most severe threat of operational failure due to an inability to meet payroll, aggressive intervention is expected to prevent a worst-case scenario of widespread corporate insolvency.