Latest Interviews
Showing 856–870 of 2,502 transcripts.
Clear all filters- Sequoia Capital56 min
The Quest to ‘Solve All Diseases’ with AI: Isomorphic Labs’ Max Jaderberg
Founded to construct a general AI-driven drug design engine, Isomorphic Labs has leveraged Demis Hassabis's Nobel Prize-winning leadership and Max Yoderberg's AI expertise to release AlphaFold 3, a diffusion-based model that predicts the 3D structures of proteins, DNA, RNA, and small molecules. By replacing months of traditional crystallization with instant in-silico analysis, the company collaborates with industry partners like Eli Lilly and Novartis to navigate the 10^60-sized chemical space and advance programs in oncology and immunology without operating its own wet labs. This approach positions AI as a fundamental, indispensable tool for the entire pharmaceutical industry within five years, while the firm advocates for new regulatory frameworks to validate these predictive models for clinical trials.
- a16z44 min
The Software Crisis Behind America's Infrastructure
Leila Hay, Phillip Buckendorf, Leonard J. Kosinski
ASI Co-founders Philip and retired General Leo Leo address the United States' critical software crisis by merging commercial aviation technology with Department of Defense logistics to replace fragmented legacy systems. Their strategy establishes a unified "collective logistics" framework that leverages AI-driven predictive capabilities to secure supply chains against cyber threats and geopolitical instability. By standardizing software stacks across the private and public sectors, the organization aims to rapidly modernize military infrastructure and maintain U.S. power projection capabilities by 2034.
- All-In Podcast1h 30m
Trump Rally or Bessent Put? Elon Back at Tesla, Google's Gemini Problem, China's Thorium Discovery
Trump, Bessent, Elon, Andrew Ross Sorkin, Chamath, Jason, Friedberg
A panel of experts analyzes global market dynamics, noting that recent rallies stem from trade deal expectations rather than Federal Reserve support, while highlighting strategic tensions over China's control of rare earths and its lead in thorium energy research. The discussion extends to foreign policy, where participants advocate for accepting the Istanbul Deal to end the Ukraine war and criticizing the moralistic approach to nation-building. Finally, the group evaluates corporate strategies for Alphabet and Tesla, the fiscal hurdles facing the Department of Government Efficiency, and the regulatory complexities surrounding Nvidia's global supply chain.
- All-In Podcast17 min
Inside the All-In Summit: Behind the Scenes of the World's Greatest Conference 🚀
JD Vance, Elon Musk, Sergey Brin, Peter Thiel, Megyn Kelly, Mearsheimer, Sachs, Travis Kalanick, Marc Benioff, Woody Hoburg, Chamath, Jason, Friedberg, TheZachEffect, Zach
The Year Three conference featured a diverse lineup of high-profile guests, including Vice Presidential candidate J.D. Vance and Elon Musk, who discussed political independence, AI development, and economic expansion amidst tight security. Notable speakers such as John Mearsheimer, Travis Kalanick, and astronaut Woody Hobart contributed to dynamic segments on geopolitics, enterprise software, and scientific scales that defined the event's unscripted format. The gathering concluded with social festivities and a forward-looking toast, highlighting the organizers' intent to foster debate through an eclectic mix of political, technological, and scientific discourse.
- The Economist9 min
Is the world still working from home?
A 2024 survey by Stanford's Nicholas Bloom across 40 nations reveals that hybrid work adoption correlates strongly with cultural individualism, ranging from 1.9 days weekly in Canada to 0.5 days in South Korea. These divergent patterns have reshaped housing markets by driving suburban price surges of up to 50% while depressing urban centers, alongside increased leisure efficiency but a notable 30-minute rise in daily solitary time. Despite concerns over social isolation, the aggregate assessment remains that remote work delivers a net positive global impact by unlocking economic efficiencies in housing and providing critical autonomy for workers.
- a16z34 min
What Comes After Mobile? Meta’s Andrew Bosworth on AI and Consumer Tech
Meta envisions a post-smartphone era driven by AI-powered AR glasses like Orion, which aim to replace touch interfaces with natural interaction modalities while leveraging open-source models to accelerate innovation. This strategic pivot shifts the market from app-centric selection to AI agent orchestration, though widespread adoption faces significant hurdles regarding hardware constraints, regulatory privacy concerns, and the societal acceptance of always-on devices. By rejecting passive technological evolution, the company positions these developments as a generational opportunity to fundamentally redesign human-computer interaction despite the risks of social backlash.
- All-In Podcast7 min
Mitotherapy Breakthrough: Supercharging Your Cells ⚡️| Science Corner with David Friedberg
Recent breakthroughs in mitochondrial biology have established physical transfer between cells and enabled the engineered amplification of mitochondria to produce 854 times normal ATP output. These advancements allow researchers to successfully repair cartilage and bone in osteoarthritis models while creating detailed brain maps that link mitochondrial dysfunction to cognitive decline. Consequently, this supply solution is launching "mitotherapy" as a viable clinical modality for treating sports injuries, heart attacks, and neurodegenerative diseases.
- a16z27 min
Powering the Next Big Things
Erin Price-Wright, Doug Burgum
Secretary Doug Burgum chairs the newly formed National Energy Dominance Council alongside Energy Secretary Chris Wright to address a declared national energy emergency driven by the AI arms race and threats from China and Iran. The administration is implementing a regulatory overhaul that utilizes AI to accelerate permitting from years to weeks, establishes Freedom Zones with guaranteed 30-day approvals, and deploys the Defense Production Act to modernize critical mineral mining and electricity generation. This strategy prioritizes abundant, reliable fossil fuel and nuclear power to support the tech sector's $300 billion infrastructure investment while explicitly excluding subsidized renewable sources.
- a16z16 min
The Kill Chain: 2025 Edition
By early 2025, the defense technology ecosystem has matured into a collaborative network where companies like Anduril, Palantir, and SpaceX are delivering autonomous systems at scale, a shift catalyzed by the war in Ukraine and accelerated by a 25-year trajectory of theoretical innovation. Anduril now prioritizes mass production of low-cost assets, including cruise missiles and undersea vehicles, to meet the U.S. government's demand for industrial capacity in great power competition rather than relying on traditional, low-volume procurement models. This evolution reflects a broader strategic pivot toward iterative development and manufacturing readiness, challenging the Department of Defense to accept calculated risks and chaos as essential components of modern warfare.
- a16z21 min
Mobilizing the American Industrial Base
This analysis argues that the U.S. defense industrial base has stagnated due to a 1990s consolidation that created monopolies and a bureaucratic procurement system that stifles innovation by prioritizing rigid regulations over visionary leadership. Speakers critique current strategies for relying on legacy manufacturing processes and call for a paradigm shift toward high-risk, high-reward projects that emulate historical "heroes and heretics" who bypassed rules to ensure victory. To address these failures and secure AI-driven autonomy, the proposed solution involves implementing integrated software platforms like Palantir to shorten feedback loops and empowering practitioners to design both the technology and its oversight rather than waiting for external regulators.
- a16z30 min
Ben Horowitz on Leadership and Culture
Ben Horowitz discusses the critical role of decisive action in leadership while outlining Andreessen Horowitz's strategic pivot to invest in defense technology and advocate for crypto-based AI infrastructure. The firm leverages its Washington, D.C. presence to shape policy, arguing that the Biden administration's refusal to engage on these issues necessitated an alignment with the current administration to foster regulatory clarity. Simultaneously, a16z deploys advanced surveillance and drone technologies in Las Vegas to improve public safety, demonstrating a practical application of these innovations to reduce profiling errors and increase crime clearance rates.
Superpower Raises $30M Series A Led by Forerunner
Superpower, led by founder Jacob Peters, secured a $30 million Series A round led by Forerunner Ventures to advance its vision of replacing fragmented healthcare with an AI-driven concierge model. The company leverages a three-part architecture of data centralization, diagnostic intelligence, and action-oriented marketplace tools to provide comprehensive health monitoring at a fraction of traditional costs. By capitalizing on widespread metabolic dysfunction and Peters' personal health crisis, Superpower aims to disintermediate the current system and build a vertically integrated preventative care network.
- a16z39 min
The Dual-Use Founder: Vets Now Building For America
Matt Shortal, John Doyle, David Tuttle, Grant Jordan
Three former military officers and defense technology veterans founded Cape and related ventures to address the asymmetry between legacy, high-cost defense systems and modern low-cost threats like commercial drones. By rejecting traditional bureaucratic structures, these companies prioritize rapid iteration and dual-use technologies that serve both national security and critical infrastructure needs. Their collective strategy aims to bridge the funding gap between early-stage prototypes and large-scale deployment while advocating for faster government acquisition cycles to match commercial innovation speeds.
- Goldman Sachs42 min
Warburg Pincus CEO Jeffrey Perlman on navigating a trickier private equity environment
Warburg Pincus CEO Jeffrey Perlman, who succeeded Chip Kaye in September 2025, outlined the firm's strategy to navigate a structural interest rate environment and declining performance persistence by leveraging a $45 billion distribution record and a "diversification by design" approach. The discussion highlighted the firm's 30th anniversary expansion in Asia, where shifting from minority stakes to majority control aims to capitalize on two-thirds of projected global growth despite tariff disruptions. Looking forward, Perlman emphasized the transformative potential of Artificial Intelligence in deal sourcing and operational efficiency while reinforcing a culture that prioritizes the institution over individual legacy.
- All-In Podcast1h 39m
Trump vs Harvard, Nvidia export controls, how DEI killed Hollywood with Tim Dillon
Trump, Tim Dillon, Chamath, Jason, Friedberg, David Sacks
The White House recently imposed indefinite export restrictions on NVIDIA's H20 chips, projecting a $5.5 billion earnings hit while prompting debates over whether enforcement will accelerate China's domestic semiconductor ambitions or effectively curb dual-use technology flows. Simultaneously, the Trump administration is contesting Harvard University over federal funding mandates, freezing billions in grants after the university refused to dismantle DEI programs and face a potential revocation of its tax-exempt status based on civil rights precedents. Experts warn that these geopolitical and educational crackdowns must address China's rising research parity with the U.S. while acknowledging that traditional university models may be too inefficient to sustain American scientific competitiveness without structural reform or AI-driven alternatives.