Latest Interviews
Showing 1021–1035 of 3,136 interview transcripts.
- a16z34 min
What Comes After Mobile? Meta’s Andrew Bosworth on AI and Consumer Tech
Meta envisions a post-smartphone era driven by AI-powered AR glasses like Orion, which aim to replace touch interfaces with natural interaction modalities while leveraging open-source models to accelerate innovation. This strategic pivot shifts the market from app-centric selection to AI agent orchestration, though widespread adoption faces significant hurdles regarding hardware constraints, regulatory privacy concerns, and the societal acceptance of always-on devices. By rejecting passive technological evolution, the company positions these developments as a generational opportunity to fundamentally redesign human-computer interaction despite the risks of social backlash.
- All-In Podcast7 min
Mitotherapy Breakthrough: Supercharging Your Cells ⚡️| Science Corner with David Friedberg
Recent breakthroughs in mitochondrial biology have established physical transfer between cells and enabled the engineered amplification of mitochondria to produce 854 times normal ATP output. These advancements allow researchers to successfully repair cartilage and bone in osteoarthritis models while creating detailed brain maps that link mitochondrial dysfunction to cognitive decline. Consequently, this supply solution is launching "mitotherapy" as a viable clinical modality for treating sports injuries, heart attacks, and neurodegenerative diseases.
- Goldman Sachs26 min
Will tariffs lead to a recession?
Paul Krugman, Jan Hatzius, Oren Cass, Allison Nathan
Prominent economists Paul Krugman, Jan Hatzius, and Oren Cass debated the Trump administration's historic tariff expansion, which Krugman identifies as an unprecedented economic shock and Hatzius projects will reduce GDP growth by two percentage points while raising recession probabilities to 45%. While Krugman warns that policy uncertainty will stifle business investment and Hatzius cautions that the Federal Reserve faces a difficult trade-off between inflation and stagnation, Cass argues the measures represent a necessary structural correction to global supply chains that will eventually stimulate domestic production. The panel concluded that although immediate data lags obscure the full extent of damage, the severity of the downturn will ultimately depend on the Federal Reserve's ability to balance conflicting price and employment mandates against a backdrop of rapidly shifting trade policy.
- a16z27 min
Powering the Next Big Things
Erin Price-Wright, Doug Burgum
Secretary Doug Burgum chairs the newly formed National Energy Dominance Council alongside Energy Secretary Chris Wright to address a declared national energy emergency driven by the AI arms race and threats from China and Iran. The administration is implementing a regulatory overhaul that utilizes AI to accelerate permitting from years to weeks, establishes Freedom Zones with guaranteed 30-day approvals, and deploys the Defense Production Act to modernize critical mineral mining and electricity generation. This strategy prioritizes abundant, reliable fossil fuel and nuclear power to support the tech sector's $300 billion infrastructure investment while explicitly excluding subsidized renewable sources.
- a16z16 min
The Kill Chain: 2025 Edition
By early 2025, the defense technology ecosystem has matured into a collaborative network where companies like Anduril, Palantir, and SpaceX are delivering autonomous systems at scale, a shift catalyzed by the war in Ukraine and accelerated by a 25-year trajectory of theoretical innovation. Anduril now prioritizes mass production of low-cost assets, including cruise missiles and undersea vehicles, to meet the U.S. government's demand for industrial capacity in great power competition rather than relying on traditional, low-volume procurement models. This evolution reflects a broader strategic pivot toward iterative development and manufacturing readiness, challenging the Department of Defense to accept calculated risks and chaos as essential components of modern warfare.
- a16z21 min
Mobilizing the American Industrial Base
This analysis argues that the U.S. defense industrial base has stagnated due to a 1990s consolidation that created monopolies and a bureaucratic procurement system that stifles innovation by prioritizing rigid regulations over visionary leadership. Speakers critique current strategies for relying on legacy manufacturing processes and call for a paradigm shift toward high-risk, high-reward projects that emulate historical "heroes and heretics" who bypassed rules to ensure victory. To address these failures and secure AI-driven autonomy, the proposed solution involves implementing integrated software platforms like Palantir to shorten feedback loops and empowering practitioners to design both the technology and its oversight rather than waiting for external regulators.
- a16z30 min
Ben Horowitz on Leadership and Culture
Ben Horowitz discusses the critical role of decisive action in leadership while outlining Andreessen Horowitz's strategic pivot to invest in defense technology and advocate for crypto-based AI infrastructure. The firm leverages its Washington, D.C. presence to shape policy, arguing that the Biden administration's refusal to engage on these issues necessitated an alignment with the current administration to foster regulatory clarity. Simultaneously, a16z deploys advanced surveillance and drone technologies in Las Vegas to improve public safety, demonstrating a practical application of these innovations to reduce profiling errors and increase crime clearance rates.
- The Economist23 min
Division multiplication: the UAE’s foreign meddling
Jason Palmer, Greg Karlstrom, Moeka Iida, John Fassman
The United Arab Emirates faces international condemnation and legal challenges at the International Court of Justice for allegedly supplying weapons to Sudan's Rapid Support Forces while simultaneously advancing diplomatic ties with the EU and acting as a mediator in the Russia-Ukraine war. In Japan, thousands of farmers staged rare protests during a historic rice shortage driven by climate damage and supply chain distortions, forcing the government to release strategic reserves despite structural policies that continue to suppress domestic production. Concurrently in the United States, the cultural debate over gender-neutral language has intensified politically, prompting a linguistic reassessment of English pronouns that highlights the historical validity and practical necessity of the singular "they" amidst efforts to codify usage through government mandates.
Superpower Raises $30M Series A Led by Forerunner
Superpower, led by founder Jacob Peters, secured a $30 million Series A round led by Forerunner Ventures to advance its vision of replacing fragmented healthcare with an AI-driven concierge model. The company leverages a three-part architecture of data centralization, diagnostic intelligence, and action-oriented marketplace tools to provide comprehensive health monitoring at a fraction of traditional costs. By capitalizing on widespread metabolic dysfunction and Peters' personal health crisis, Superpower aims to disintermediate the current system and build a vertically integrated preventative care network.
- The Economist21 min
Cardinals in: choosing the next pope
Jason Palmer, John Hooper, Sarah Burke
Following Pope Francis's death, the Catholic Church prepares for a high-stakes conclave where key figures like Camerlengo Kevin Farrell and Dean Giovanni Battista Re must navigate deep ideological divisions regarding geopolitical strategy and sexual abuse accountability. Simultaneously, Mexico faces a deepening humanitarian crisis as the discovery of a CJNG cartel training camp with cremation ovens underscores the rising disappearance rate under current and previous administrations, prompting President Claudia Sheinbaum to propose reforms despite severe forensic resource gaps. In the entertainment sector, the *Minecraft* film's record-breaking $300 million opening signals a potential revival for theatrical eventing by targeting the teenage demographic, even as unruly TikTok-fueled behavior forces theaters to implement strict attendance policies.
- Goldman Sachs42 min
Warburg Pincus CEO Jeffrey Perlman on navigating a trickier private equity environment
Warburg Pincus CEO Jeffrey Perlman, who succeeded Chip Kaye in September 2025, outlined the firm's strategy to navigate a structural interest rate environment and declining performance persistence by leveraging a $45 billion distribution record and a "diversification by design" approach. The discussion highlighted the firm's 30th anniversary expansion in Asia, where shifting from minority stakes to majority control aims to capitalize on two-thirds of projected global growth despite tariff disruptions. Looking forward, Perlman emphasized the transformative potential of Artificial Intelligence in deal sourcing and operational efficiency while reinforcing a culture that prioritizes the institution over individual legacy.
- The Economist20 min
A man of the people: Pope Francis has died
Pope Francis, Jason Palmer, Anne Rowe, Avantika Chalkoti, Juergen Esser, Andrew Palmer
Pope Francis has implemented a radical reform strategy within the Catholic Church by prioritizing mercy and direct engagement while facing internal resistance from the Curia regarding child abuse protocols and doctrinal changes. Simultaneously, the global high-protein market is surging due to GLP-1 drug usage and shifting consumer demographics, prompting major manufacturers like Danone and Nestlé to launch specialized products despite warnings of unnecessary supplementation. In the corporate sector, organizations are increasingly addressing workplace turnover by replacing indirect "quiet firing" tactics with purpose-alignment workshops, a method proven to improve productivity while naturally separating low-performing employees.
- All-In Podcast1h 39m
Trump vs Harvard, Nvidia export controls, how DEI killed Hollywood with Tim Dillon
Trump, Tim Dillon, Chamath, Jason, Friedberg, David Sacks
The White House recently imposed indefinite export restrictions on NVIDIA's H20 chips, projecting a $5.5 billion earnings hit while prompting debates over whether enforcement will accelerate China's domestic semiconductor ambitions or effectively curb dual-use technology flows. Simultaneously, the Trump administration is contesting Harvard University over federal funding mandates, freezing billions in grants after the university refused to dismantle DEI programs and face a potential revocation of its tax-exempt status based on civil rights precedents. Experts warn that these geopolitical and educational crackdowns must address China's rising research parity with the U.S. while acknowledging that traditional university models may be too inefficient to sustain American scientific competitiveness without structural reform or AI-driven alternatives.
- Y Combinator38 min
How Zepto Became India’s Fastest Growing Startup
Zepto co-founders Aadit Palicha and Aadit Palicha (KB) scaled a Mumbai-based grocery startup into a $5 billion unicorn by pioneering a "customer backward" dark store model that delivers 1.5 million daily orders across 50 Indian cities in ten minutes. The company achieved financial efficiency by breaking even just over two years ago despite a global capital freeze, while diversifying revenue streams through advertising and new verticals like Zepto Cafe. Driven by a long-term vision to rival global giants like Amazon, Zepto leverages generative AI and a cost-effective Indian talent pool to expand beyond groceries into electronics and general merchandise.
Inside the $350M Pelosi Stock Tracker
Autopilot, formerly known as the Nancy Pelosi stock tracker, is a venture-backed fintech platform that has grown to manage $500 million in assets for 2.5 million users before pivoting to a creator economy model allowing influencers to offer tradable portfolios. The company leverages its history of tracking high-performing politicians like Nancy Pelosi and Richard Burr to highlight market timing disparities while advocating for the bipartisan "Pelosi Act" to ban congressional stock trading. Having generated eight-figure revenue without a down month, Autopilot is transitioning from a single-figure focus to a sustainable social investing ecosystem funded by roughly $7 million in venture capital.