Dr. Thomas Rando

a16z Podcast | The Science Of Extending Life

Dr. Thomas Rando, Kristen Fortney, Vijay Pande, Hannah

Geroscience has transitioned from theoretical concepts to validated interventions like rapamycin and senolytics, which extend lifespan by up to 30% in mammalian models while genomic biomarkers accelerate drug testing from decades to years. Regulatory frameworks are evolving to approve age-delaying therapies such as the FDA's review of the TAME metformin trial, shifting focus from treating specific diseases to preventing aging as a primary risk factor. BioAge and other entities are developing diverse therapeutics to add healthy years to life, aiming to generate massive public cost savings and reshape demographics despite challenges regarding equity and access.