Latest Interviews
Showing 2011–2025 of 3,506 transcripts.
Clear all filters- Milken Institute1h 2m
Outsmarting Superbugs: What Are the Alternatives?
Margaret Hamburg, Matthew Hepburn, Peter Jackson, Nancy Knight, Jeanette Mucha, Peter Piot, Peggy Hamburg, David Wallace, Lance Price
Global leaders and organizations including the WHO, CDC, and the U.K. government are coordinating a multi-faceted response to antimicrobial resistance, which threatens to cause 10 million annual deaths by 2050 and mimic the 2008 financial crisis through massive economic losses. Innovative initiatives such as the CDC's AMR Challenge, Carb-X's $80 million funding for 40 development projects, and the U.K.'s "pull incentive" trial aim to revitalize the antibiotic pipeline by supporting SMEs and rewarding disease prevention rather than sales volume. Despite these advances, experts warn that rigid intellectual property laws, inadequate wastewater treatment, and capital gaps in microbiome startups hinder the deployment of new therapies needed to combat untreatable superbugs like drug-resistant tuberculosis.
- Milken Institute1h 22m
Toward a Healthier Future
Will Durant, Mike Milken, Tanisha Carino, Michael Milken, Francis Collins, Susan Desmond-Hellmann, Bernard J. Tyson, Seema Verma, Sue Desmond-Hellman
Representatives from the Gates Foundation, Kaiser Permanente, CMS, and NIH converged to outline a unified strategy shifting global health systems from reactive treatment toward proactive prevention and precision medicine. Leaders highlighted specific breakthroughs in gene therapy, AI-driven neural decoding, and data interoperability while proposing structural reforms to align financial incentives with long-term population wellness and disease eradication. The consensus among these major institutions emphasizes that future economic prosperity and reduced healthcare costs depend on integrating community infrastructure, digital infrastructure, and innovative financing models to address challenges ranging from mental health crises to rare genetic disorders.
- Milken Institute1h 2m
Envisioning the Future of Media and Entertainment
Julia Boorstin, Jeffrey Hirsch, Gale Anne Hurd, Charles D. King, Asif Satchu, Jeremy Zimmer, Jeff Hirsch
Industry leaders project a fragmented streaming landscape where major consolidators like Netflix and Disney+ coexist with premium add-on services, driven by a shift in creator leverage toward aggressive upfront deals over traditional backend participation. While writers face income compression due to shortened production cycles and structural residual gaps, the market is simultaneously evolving toward data-driven meritocracy that could reinstitute performance-based royalties. This evolution extends globally, with content featuring underrepresented demographics and non-U.S. productions becoming central to international revenue growth alongside a compressed theatrical window strategy.
- Lex Fridman1h 0m
Rosalind Picard: Affective Computing, Emotion, Privacy, and Health | Lex Fridman Podcast #24
Rosalind Picard, the pioneer of affective computing, argues that while machines can now detect emotional states with over 80% accuracy using wearable sensors, the field remains limited to narrow contexts and poses significant ethical risks regarding privacy and authoritarian surveillance. She advocates for strict regulations that separate emotional analysis from commercial exploitation and criminalizes non-consensual emotion detection, emphasizing that current AI cannot replace genuine human connection or consciousness. Ultimately, Picard urges the industry to shift focus from generating wealth to solving critical health challenges, such as predicting fatal epilepsy seizures, thereby using technology to empower underserved populations rather than consolidating power.
- Milken Institute56 min
The City for All Ages: Harnessing the Promise of Longevity
James Anderson, Dan Buettner, Carol Coletta, Rodney Slater, Jan Vapaavuori, Jim Anderson
Leading urban experts and policymakers converge to address the unprecedented demographic shift where the global population over 65 now exceeds those under 5 by advocating for built environment interventions over individual behavioral changes. Drawing on longevity strategies from Blue Zones and Helsinki's intergenerational housing models, the panel proposes that mayors and civic leaders actively redesign cities to make healthy choices the default option through walkability, social integration, and regulatory nudge policies. These initiatives aim to transform the "silver economy" into a catalyst for civic innovation, ensuring that aging populations remain healthy, employed, and socially connected while reducing the strain on healthcare systems.
- Milken Institute1h 2m
The Age of Private Equity and Credit
Jim Moglia, Glenn August, Victor Khosla, Greg Lippmann, Virginie Morgon, Raymond Svider
Leading alternative asset managers including Oak Hill Advisors, Strategic Value Partners, and BC Partners are redirecting capital from public markets to private credit to secure higher yields amid a 45% decline in public U.S. companies. Panelists highlight that rising institutional return targets, combined with tight investment-grade spreads, are driving a $5.7 trillion migration into private capital while disintermediating traditional commercial banks. Despite late-cycle valuation concerns, these firms are expanding direct lending capabilities and integrating ESG and diversity frameworks to mitigate liquidity risks and maintain long-term operational competitiveness.
- Y Combinator50 min
Tracy Young on Scaling PlanGrid to 400+ People with YC Partner Kat Manalac
Tracy Young, Kat Manalac, Craig Cannon, Fredi Fernández, Seyed Rasoul Jabari, Holly
Founded in the 2012 Y Combinator batch by Tracy Young and Ryan Sutton, PlanGrid digitized construction workflows by deploying an iPad-based platform that utilizes overlay technology and version control to prevent blueprint errors. The company bypassed traditional enterprise sales channels by targeting field workers directly, growing organically to 450 employees before being acquired by Autodesk. Now integrated into Autodesk's 1,200-person construction division, the startup focuses on international expansion to eliminate billions in annual industry waste while maintaining a founder-led culture centered on authenticity and role clarity.
- Milken Institute59 min
Common Sense from Uncommon Investors
Michael Milken, Jonathan Coslet, John Danhakl, Mitchell Julis, Brian Sheth, Steven Tananbaum, Mike Milken
Industry leaders from Leonard Green & Partners, Canyon Partners, Vista Equity Partners, GoldenTree Asset Management, and TPG convened to discuss evolving strategies in private equity, corporate debt, and technology investing. These executives detailed critical shifts in their operational frameworks, ranging from Canyon's resistance to AI in bespoke financial structuring to Vista's data-driven talent acquisition and GoldenTree's transformation of CLOs into fund structures. The dialogue further examined the necessity of aligning investor and management interests through diverse ownership models and the strategic preference for absolute value over relative metrics in a shifting macroeconomic environment.
- Milken Institute1h 0m
Blockchain Technology: What Is It Good for, Really?
Staci Warden, Elad Gil, Sandra Ro, Stefan Schulz, Bill Tai, Tomicah Tillemann
Milken Institute moderator Stacey Worden led a panel including Elad Gil, Sandra Rowe, and Bill Tai to define blockchain's superior utility in scenarios requiring trustlessness, open ledgers, privacy, or programmability, while arguing that centralized databases remain optimal for all other applications. The discussion highlighted transformative real-world adoptions ranging from Power Ledger's peer-to-peer energy trading and Bill Tai's $35 million real estate tokenization to Estonia's governance models and New York City's digital benefit wallets. Panelists concluded that overcoming regulatory fragmentation and data integrity risks is essential as the industry shifts from financial speculation toward building a global infrastructure for financial inclusion and automated asset management.
- Lex Fridman1h 9m
Gavin Miller: Adobe Research | Lex Fridman Podcast #23
Adobe Research is advancing creative workflows by shifting from manual pixel manipulation to intent-based automation, exemplified by tools like Project Sky Replacement and Generative Fill that utilize deep learning to bridge the gap between human creativity and machine execution. The lab operates on a collaborative model where AI provides smart defaults and assistive suggestions, allowing human users to intervene for final quality assurance while leveraging vast data libraries to build context-aware educational features. Strategic initiatives including the Sensei platform and high-risk intern programs aim to centralize neural models and drive innovation, ultimately fostering a future where generative AI and immersive technologies enhance content velocity without compromising professional reliability or ethical standards.
- Y Combinator49 min
Simone Giertz on Her Robots and Returning to Work After Brain Surgery
Simone Giertz, Adam Savage, Craig Cannon, Ali, beep boop, Beste, Khawar Shehzad, Olaf Doschke, Johnathan Nader
Following a brain tumor diagnosis and subsequent surgery in the previous year, electronics engineer turned YouTuber Simone Yetch is diversifying her career by launching a product design company centered on a high-end, 365-day interactive calendar scheduled for a mid-June release. This strategic shift from viral "shitty robots" to serious hardware allows her to build independent revenue streams while maintaining a creative philosophy that prioritizes health boundaries, play, and the rejection of restrictive media contracts. Yetch currently balances multiple projects and recovery needs with a defined goal to step back from content creation entirely by age 55 to pursue alternative life paths.
- Lex Fridman1h 11m
Rajat Monga: TensorFlow | Lex Fridman Podcast #22
Launched by Google Brain in 2011, the TensorFlow ecosystem has evolved from a proprietary deep learning library into a globally adopted platform with over 41 million downloads and 1,800 contributors. The framework is currently transitioning to version 2.0, which defaults to eager execution and unifies its API around Keras to resolve developer confusion while preserving backward compatibility for enterprise systems. Driven by a distributed governance model and competition from alternatives like PyTorch, the project aims to democratize machine learning across diverse hardware, from mobile devices to cloud TPUs, by simplifying model development and addressing enterprise data organization challenges.
- Milken Institute57 min
Right or Left: Who's Best for Freedom?
Josh Barro, Kenneth Hersh, Rich Lowry, Gene Sperling, Felicia Wong
In a debate contrasting FDR's positive liberties with classical negative freedoms, Felicia Wong and Gene Sperling argue that true liberty requires protection from want and fear, while Rich Lowry and Kenneth Hirsch contend that freedom is strictly defined by the absence of government coercion. The panel further explores how economic policies like the Affordable Care Act and anti-discrimination laws either expand individual agency or threaten consumer choice, while noting that shifting political narratives now force conservatives to defend liberty against a backdrop of authoritarianism and rising public demand for government intervention. Ultimately, the discussion highlights a deep ideological divide over whether freedom entails securing material security and dignity through state action or preserving it through limited government and market competition.
- Milken Institute1h 3m
eSports: The Bumpy Ride to ROI
Ben White, Sam Englebardt, Peter Levin, Kristen Salvatore, Ari Segal, David Rockefeller Jr., Emily Fortuna, Amanda Han, Eric Schmidt, Ari Schwartzmann, Sam Nelsons, Chai, Peter Barron, Peter Barry Kaufmann, Kevin, Carlos, Paul
Industry leaders highlight that gaming now surpasses film and television in scale, with a user base of 2.6 billion driving a strategic shift for traditional media and sports organizations to secure the Gen Z demographic. Investment activity is surging as entities like Immortals Gaming Club adopt holding company structures to capture high valuations and leverage the mobile boom, while platforms like Twitch demonstrate superior engagement metrics that attract non-endemic advertising. Amidst these rapid expansions, the sector faces evolving structural debates regarding player welfare, the rise of influencer-driven brands over traditional franchises, and the impending need for standardized unionization and global regulatory frameworks.
- Milken Institute52 min
Inside a Blockbuster Franchise: "Avengers: Endgame"
Julia Boorstin, Anthony Russo, Joe Russo, David Levinson, John McCutchan
Directors Joe and Anthony Russo leveraged a unique back-to-back production strategy and a global day-and-date release to propel *Avengers: Endgame* to a record-breaking $1.2 billion opening weekend. Their collaborative "mastermind" approach, which integrated scientific consultation and disciplined ensemble management, transformed the film into a universal cultural phenomenon while reaffirming the distinct value of the theatrical experience. Building on this success, the Russo brothers are now expanding their AGBO production company to champion artist ownership and emerging talent with projects like *Cherry*, all while maintaining a format-agnostic commitment to both streaming and cinema.