Latest Interviews

Mass extinction: what can stop it?

Katrine Brahek

Experts warn that human reliance on deteriorating ecological networks, with one million species at risk of extinction, poses an immediate threat to global food security and climate stability. While advanced technologies like AI-powered trail guards and satellite imaging have improved monitoring and anti-poaching efforts, these tools remain ineffective without robust political will and enforceable policies. The failure to meet the 2020 Aichi conservation targets highlights an urgent need for governments to transition from vague goals to funded, ground-level interventions to prevent a catastrophic ecological collapse.

Biotech and the Transition from Pandemic to Endemic

Chris Shibutani, Liz

The event analyzes the global transition toward an endemic phase for COVID-19, highlighting a significant disparity where Western nations with high immunization rates differ from the majority of countries in Africa, Asia, and Latin America that remain in the pandemic stage. Industry leaders at BioNTech, Pfizer, and Moderna are currently developing multivalent mRNA vaccines to merge seasonal flu and coronavirus protection, shifting strategies toward frequent boosters to manage waning immunity. The discussion underscores the unprecedented speed of regulatory transparency and clinical development achieved last year while warning against complacency as the world prepares for future pandemic threats.

Why DAOs Matter for Digital Art

pplpleasr, People Pleaser

Digital artist People Pleaser transitioned from traditional animation to the cryptocurrency sector, generating a 310 ETH sale for her Uniswap v3 teaser that catalyzed the creation of Pleaser DAO. Led by co-founder Layton Cusack of Pool Together, this decentralized organization functions as a collective patron for DeFi artists while prioritizing charitable donations and innovative financial mechanisms like NFT fractionalization. Building on this mission, Pleaser immediately launched a follow-up NFT titled "Apes Together Strong," which funds autism advocacy and further explores the integration of animation, community governance, and DeFi lending protocols.

Is Myanmar a failed state?

Following a February 1st military coup that has resulted in over 780 deaths and 3,800 arrests, the junta has detained de facto leader Aung San Suu Kyi on multiple charges while facing a nascent civil war as the Bamar majority joins ethnic militias in armed resistance. Although international sanctions and diplomatic pressure from the West have targeted senior generals, robust intervention remains blocked by veto power wielded by China and Russia, who prioritize regional infrastructure and strategic arms sales. Consequently, Myanmar risks becoming a failed state plagued by collapsing health systems, uncontrolled drug production, and cross-border refugee flows, while the military inherits a devastated economy despite its current control.

Squire, Edlyft, Promise: The Journey, Challenges, & Impact

Squire, Edlyft, Promise, Songe LaRon, Dave Salvant, Erika Hairston, Arnelle Ansong, Phaedra Ellis-Lamkins, Diana Frappier

Founders Song Laurent of Squire, Erika Hairston and Arnelle Ansong of Edlift, and Phaedra Ellis-Lampkins of Promise presented at Y Combinator, detailing how they leveraged prior Big Tech experience and rigorous bootstrapping tactics to address critical market inefficiencies. Their startups successfully tackled distinct challenges by modernizing the barbershop industry, expanding access to computer science for underrepresented students, and facilitating government debt repayment to bridge racial wealth gaps. The session highlighted how building resilient, diverse institutions supported by the YC community enables these leaders to sustain long-term impact while encouraging greater investment in Black founders to solve systemic global problems.

Christine Lagarde: How covid-19 will shape Europe

Christine Lagarde, Zannie Minton-Beddoes, Miranda Johnson

Christine Lagarde identifies Europe as the current pandemic epicenter and highlights data suggesting female leaders possess superior crisis management attributes compared to their male counterparts. She argues that the crisis has disproportionately worsened inequality for women in informal sectors, necessitating government-led interventions such as board quotas and structured support pipelines to ensure recovery. Looking ahead, Lagarde outlines plans for the "Next Generation EU" funds to drive green and digital transformation, while noting that fiscal stimulus and the potential rollout of a central bank digital currency will be critical for a robust economic rebound in 2021 and beyond.

Covid-19 vaccines: what information can you trust?

Ed Carr, Natasha Loder

Regulatory bodies and bioethicists are navigating complex challenges including the deployment of single-dose Johnson & Johnson vaccines, the strategic extension of mRNA dosing intervals to boost population immunity, and the ethical implications of mandatory vaccination or vaccine passports. While media outlets must carefully distinguish between chance adverse events and vaccine causation, experts emphasize that the rapid adaptability of mRNA platforms provides a robust foundation for updating shots against future viral mutations. Ultimately, governments favoring pragmatic public health measures over legal mandates are balancing rising hospitalization rates with the risk of fueling vaccine hesitancy among the public.

Cindy McCain: what next for the Republican Party?

Cindy McCain, Joe Biden, John McCain, Donald Trump

Cindy McCain, the widow of Senator John McCain, asserts that the Republican Party has strayed from its historic values of inclusion and predicts a potential fracture due to current high partisanship and the January 6th insurrection. She contrasts the recent violence with the successful democratic transition under President Joe Biden, whom she praises for prioritizing bipartisanship and immediate crisis management regarding the coronavirus pandemic. Ultimately, McCain envisions a new era of cooperation where the law-abiding majority within the party helps restore the United States' global standing as a beacon of hope and democratic stability.

Bill Gates: How to fund the green revolution

Bill Gates, Zanny Minton Beddoes

Bill Gates outlines the necessity of achieving net-zero emissions through massive technological innovation to solve hard-to-abate industrial sectors like steel and aviation, rather than relying solely on behavioral change. He argues that a $2 trillion global investment strategy must prioritize public R&D funding and venture capital to eliminate the green premium, with the United States serving as the essential exemplar and primary buyer to drive down costs. While carbon taxes remain politically elusive, the path forward requires governments and corporations to shift from symbolic actions to substantive financing of real decarbonization technologies alongside historical emission reductions.

Desining from Day One: Artists as Founders: Multiverse (S20) - YC Gaming Tech Talks 2020

Hisham, Sara, Sarah

Multiverse, a Y Combinator-backed platform founded by two MIT engineers and illustrator Sara, is developing a hybrid of Dungeons & Dragons and Roblox to digitize tabletop RPGs into a visual, streamable online experience. The company differentiates itself by prioritizing high-fidelity narrative art as a core business asset, recruiting top-tier indie creators from platforms like ArtStation and Twitch rather than traditional AAA studios to drive user engagement and market validation. By granting equity to its artistic co-founders and leveraging visual assets for fundraising, Multiverse aims to bridge the gap between scrappy entertainment storytelling and scalable platform economics.

Life after Trump: what’s the future of the Republican Party?

Trump, Joe Biden, Idris Kahloun, James Astle

Despite his 2020 election loss, Donald Trump maintains dominant control over the Republican Party, compelling former critics like Lindsey Graham and Marco Rubio to align with his populist platform to avoid electoral backlash. This entrenched loyalty, reinforced by base support for the 2020 election fraud narrative, has created a fragmented media ecosystem and left Trump with minimal internal opposition as he contemplates a 2024 run. Analysts warn that the party's future trajectory remains volatile, with the strength of Trump's personal appeal serving as the decisive factor in either cementing a populist era or allowing for a potential succession.

Stephen Hawthornthwaite, Chairman and CEO of Rothy’s

Stephen Hawthornthwaite, Jennifer Davis, Stephen Hawthorne-Puig

Founded in 2012 by finance professionals Stephen Hawthorne-Puig and Roth Martin, Rothy's revolutionized the footwear market by launching seamless, machine-washable shoes produced from recycled plastic through a vertically integrated supply chain. The company achieved profitability in 2016 while remaining self-funded, leveraging 3D knitting technology and a core sustainability strategy to build a loyal customer base that drives over half of its traffic through word-of-mouth. Now expanding into handbags and exploring international growth and physical retail, Rothy's maintains a robust research pipeline for men's footwear while continuing to prioritize long-term sustainability over rapid scaling.

Healthcare: The Great Unlock

Julie Yoo

Accelerated by the pandemic, the healthcare sector is compressing a decade of transformation into two to three years through a fundamental shift from local, fee-for-service models to national, digital-first, value-based care. This dislocation is driven by labor reversals, insurance coverage changes, and regulatory mandates that favor remote care, forcing legacy providers to cede ground to startups owning the end-to-end patient journey. Consequently, a once-in-a-generation opportunity has emerged for startups to replace fragmented infrastructure with an automated, interoperable operating system that utilizes AI for intelligent supply-demand matching and dynamic insurance products.

Carbon Offsets and the Climate Transition

Sharmini Chetwode, Liz

The carbon offset market functions as a temporary financial bridge for heavy industries unable to immediately decarbonize, offering compliance and voluntary options ranging from renewable investments to forestry projects. Despite growing shareholder pressure and expanded Scope 3 reporting mandates, the sector faces significant skepticism regarding pricing volatility, verification risks, and its inability to fundamentally shift business models. While Asian companies lag in adopting climate targets, global firms in steel, cement, and transportation face future margin contractions as carbon prices rise, necessitating a strategic pivot away from reliance on offsets toward genuine operational decarbonization.

Covid-19: what will happen to the global economy?

Zanny Minton Beddoes, Edward Carr

The pandemic has triggered the deepest global recession since the 1930s, establishing a permanent "90 economy" where behavioral shifts rather than lockdown mandates drive lasting contraction in sectors like tourism and manufacturing. While the United States has retreated from global coordination, China is expanding its digital financial influence, though a full displacement of the US dollar remains a prolonged process due to historical inertia. Concurrently, developing nations face acute vulnerability from debt burdens and export shocks, while youth unemployment risks causing long-term labor market scarring that necessitates diversifying supply chains rather than abandoning globalization.