Latest Interviews

Early Decision for Students

Y Combinator is launching an "Early Decision" track specifically for graduating seniors to apply during their final year of study, securing guaranteed funding and a spot in the Summer 2026 batch. This program eliminates the immediate pressure to interview for traditional employment by providing financial support and a committed place in a future cohort before graduation. By allowing founders to receive capital and enrollment immediately, the initiative enables students to focus entirely on building their startups while completing their degrees.

What is the future of the UN?

Anton La Guardia, Jason Palmer

Amidst its 80th anniversary and severe funding crises driven by potential US abandonment, the United Nations faces existential threats from eroding border sanctity and budget cuts forcing agencies to reduce spending by up to one-third. While a French-led coalition recently recognized a Palestinian state to offer symbolic momentum, the organization's future remains uncertain as it navigates three divergent scenarios: becoming a rogue entity separated from Washington, decaying into a shrunken but bureaucratic shell, or being reshaped into a transactional tool for American leadership. Ultimately, experts warn that a strategic vacuum left by US withdrawal could allow Russia and China to dominate global diplomacy, despite the independent continuity of technical agencies like the ICAE and IAEA.

Software Finally Eats Services - Aaron Levie

Aaron Levie, Erik Torenberg, Steven Sinofsky, Martin Casado

The event analyzes how AI is accelerating a universal adoption curve that empowers young founders and small teams to achieve unprecedented productivity gains by acting as a turbocharger for domain expertise rather than a replacement for it. Participants debate the implications of Reed Hastings' visa salary proposal and discuss how incumbent corporations face disruption from agile startups leveraging non-deterministic workflows to redefine vertical industries. The discussion concludes that while historical leaders will likely expand, the most significant future value creation will emerge from entirely new categories built by the next generation of AI-native entrepreneurs.

Taking Bold Bets: NIH and the Future of Biomedical Science

Dr. Jay Bhattacharya, Erik Torenberg, Vineeta Agarwala, Jorge Conde

Secretary Xavier Becerra announced a $50 million federal investment to launch the Autism Data Science Initiative, selecting 13 teams from 250 applicants to address the rising prevalence of autism and the lack of effective therapies. Concurrently, the NIH is implementing comprehensive reforms to resolve the scientific replication crisis, centralize peer review, and prioritize early-career investigators to foster high-risk innovation. These strategic shifts aim to rebuild public trust through transparent communication, integrate AI for capacity augmentation, and tackle chronic diseases while ensuring rigorous, reproducible medical standards.

Why Now Is The Best Time To Build In Crypto

Harj Taggar, Jesse Pollak

Led by Base founder Jesse Pollock, industry leaders declare a new golden age for crypto building driven by mature infrastructure that has reduced transaction costs to near zero and achieved regulatory clarity through legislation like the Genius Act. This environment enables a shift from legacy financial systems to programmable, censorship-resistant networks where stablecoins facilitate global access and tokenization allows creators to retain ownership of their capital. As a result, Coinbase and Y Combinator are prioritizing technical founders who apply these scalable Layer 2 architectures to solve real-world problems, signaling a surge in high-quality engineering teams ready to integrate AI and financial services over the next 18 months.

Why Businesses Are Rejecting the AI They’ve Asked For ft Agency CEO Elias Torres

Elias Torres, Sonya Huang, Pat Grady

Elias Torres leverages his experience founding Drift and leading HubSpot's platform rebuild to launch Agency, an AI-native company dedicated to automating entire customer workflows rather than merely assisting human agents. The venture targets enterprise clients by challenging the market's demand for perfect AI accuracy, instead promoting a model that delivers broad functionality with 10-30% efficiency gains while relying on fewer than 100 employees to scale operations. Torres aims to build a $1 billion revenue entity by deprogramming businesses from manual dependency and hiring talent driven by grit and hunger over traditional credentials.

Disaster Preparedness and Community Resilience | Global Conference 2025

Raj Kumar, Christoph Gorder, Louis A. Gritzo, Donald Howard, Vanessa Kerry, Michelle Nunn, DAN GALPIN

Industry leaders and humanitarian officials warn that escalating climate disasters and drastic foreign aid cuts necessitate a strategic pivot from reactive emergency response to proactive public-private resilience investments. By leveraging technology for rapid housing solutions and engineering for risk reduction, experts demonstrate how preventing damage yields billions in savings while addressing critical workforce shortages in reconstruction. The consensus emphasizes that future security and economic stability depend on community-led planning, direct investment in high-risk regions, and treating climate adaptation as a core driver of operational continuity rather than a peripheral cost.

General Catalyst CEO, Hemant Taneja: Lessons Scaling GC to $40BN in AUM

Hemant Taneja, Harry Stebbings

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Dylan Patel on the AI Chip Race - NVIDIA, Intel & the US Government vs. China

Dylan Patel, Erik Torenberg, Sarah Wang, Guido Appenzeller

NVIDIA and Intel have established a transformative $5 billion strategic partnership to jointly develop custom data center and PC products, a move that significantly boosted NVIDIA's stock and acknowledged the industry's shift from CPU to GPU dominance. This alliance contrasts sharply with China's aggressive pursuit of semiconductor self-sufficiency, where Huawei navigates US export bans and high-bandwidth memory bottlenecks through domestic innovation and alleged smuggling channels. Simultaneously, hyperscalers like Oracle and AWS are capitalizing on surging demand with massive infrastructure deals and repurposed capacity, while the market faces technical complexities in deploying next-generation Blackwell architectures and optimizing hardware for specific inference workloads.

Insulin Doctor: The Fastest Way To Burn Dangerous Visceral Fat! I'm Finding Mould In My Patients!

Dr. Pradip Jamnadas

Dr. Jamnadas presents a comprehensive framework for preventing and reversing coronary artery disease by targeting inflammation and hyperinsulinemia as the primary drivers of vascular damage rather than cholesterol alone. The protocol integrates specific fasting cycles to mobilize visceral fat, optimize mitochondrial function through ketones, and repair endothelial lining via autophagy, alongside lifestyle adjustments such as high-intensity interval training and rigorous environmental toxin reduction. By utilizing advanced diagnostics like coronary calcium scoring and insulin panels, this approach aims to halt disease progression and restore physiological health through a holistic return to natural metabolic rhythms.

Critical Minerals, Critical Risks: Securing Supply Chains | Global Conference 2025

Daniel Yergin, Frank Fannon, Nicholas Myers, Kei Onishi, Vandita Pant, Nick Myers

Driven by surging demand from AI infrastructure and electrification, the global market faces a critical supply gap that requires doubling copper production by the mid-2030s. While China currently dominates rare earth output and smelting capabilities, emerging U.S. ventures like Phoenix Tailings are leveraging zero-emission technologies to process industrial waste and secure supply chains. Strategic investments from major automakers and corporate venture arms are accelerating domestic refining and exploration, yet the sector remains constrained by decades-long permitting cycles and a massive infrastructure funding deficit.

Transforming Food for a Healthier Future | Global Conference 2025

Holly Freishtat, Alice Hm Chen, Sarah Mastrorocco, Ashley Tyrner-Dolce, Aaron Wiese

Industry leaders from Centene, Hy-Vee, FarmboxRx, and Instacart are redefining healthcare strategy by treating food as a primary preventive tool rather than a mere treatment, leveraging data to prove that medically tailored nutrition significantly reduces chronic disease costs. This shift is driven by evidence that 50% of U.S. adults suffer from preventable diet-related conditions, prompting payers and retailers to integrate food access into care management despite regulatory ambiguities surrounding "healthy" food definitions under changing SNAP and Medicare Advantage rules. As the sector targets a 2035 vision of seamless access, stakeholders are balancing urgent clinical outcomes with the complex logistics of scaling personalized nutrition interventions across fragmented state policies.

Charlie Kirk Murder, Assassination Culture in America, Jimmy Kimmel Suspended, Ellison Media Empire

Charlie Kirk, Jimmy Kimmel, Ellison, Chamath, Jason, Friedberg, Zach, Sax

Following the murder of conservative activist Charlie Kirk by Tyler Robinson, a discussion emerges attributing the violence to a radicalized generation shaped by algorithmic extremism and social isolation rather than a random act. The event has triggered a broader national debate regarding the rising acceptance of political violence and the specific cancellation of Jimmy Kimmel, which hosts frame as a symptom of media consolidation and the erosion of free speech norms. Participants conclude by calling for a societal pledge against political violence while analyzing how tech giants and media moguls are reshaping the information landscape that fuels such ideological fractures.

Norman Ohler: Hitler, Nazis, Drugs, WW2, Blitzkrieg, LSD, MKUltra & CIA | Lex Fridman Podcast #481

Norman Ohler, Lex Fridman, Ian Kershaw, Antony Beevor

This historical analysis details the systematic deployment of Pervitin methamphetamine by Nazi Germany to enable the rapid 1940 Western Campaign and examines Adolf Hitler's accelerating opioid dependency under physician Theodor Morel. The narrative connects state-sponsored drug use to critical military outcomes, including the failed pursuit at Dunkirk, while simultaneously documenting the internal resistance of the Schulze-Boysen network and the postwar legacy of Nazi pharmaceutical research in CIA mind-control programs. By synthesizing these elements, the work argues that while psychoactive substances significantly impaired leadership judgment and tactical execution, they did not absolve the regime of responsibility for its genocidal crimes.

A New Era of Military Technology | Global Conference 2025

Rick Newman, Jeff Cole, Matt Markel, Mariam Sorond

This Milken Institute panel brought together defense technology startups Hidden Level, Epirus, and NextNav to demonstrate how agile, non-traditional contractors are closing critical warfare gaps left by legacy primes. Highlighting specific operational successes, the session detailed Hidden Level's passive radar for rapid drone detection, Epirus's high-power microwave systems for cost-effective kinetic disruption, and NextNav's 5G-based terrestrial positioning as a GPS alternative. Executives and strategists concluded that leveraging rapid-acquisition pathways like OTAs is essential to overcoming bureaucratic inertia while securing US technological resilience against global threats.