Latest Interviews
Showing 391–405 of 585 transcripts.
Clear all filters- Y Combinator17 min
Reshma Shetty, Founder of Ginkgo Bioworks at the Female Founders Conference
Ginkgo Bioworks, a Boston-based female-founded unicorn, leverages the digital nature of DNA to program organisms with sub-nanometer precision while advising founders to raise substantial capital only under strict fiscal discipline to avoid the pitfalls of organizational bloat. The company distinguishes its scaling strategy by enforcing efficiency through a "Scrooge McDuck" leadership role and a "Mission to Metrics" framework that explicitly links its core goal of making biology easier to engineer with quantitative measures like output per employee. This approach allows Ginkgo to decouple commercial growth from headcount expansion, thereby mitigating non-linear interpersonal conflicts and sustaining a competitive advantage despite rapid organizational expansion.
- Y Combinator1h 14m
Fermat's Library Cofounders João Batalha and Luís Batalha
João Batalha, Luís Batalha, Mika, Timor, Francesc Campoy Flores, Mark Mandelmann
Fermat's Library is a browser-based platform founded by four MIT alumni that enables researchers to annotate academic papers using LaTeX and Markdown to simulate an offline journal club experience. The team has grown the site by hosting over 1,000 documents, including the most commented-on Bitcoin whitepaper, and deployed a Chrome extension for arXiv to facilitate real-time collaboration on preprints. By promoting open science principles and addressing systemic issues like the lack of incentives for negative results, the platform aims to evolve into a global "Stack Overflow for science" that supports peer review and knowledge discovery outside traditional paywalls.
- Y Combinator3h 39m
Female Founders Conference - New York
Jessica Livingston, Kathryn Minshew, Alex Cavoulacos, Mariya Nurislamova, Reshma Shetty, Shan-Lyn Ma, Reham Fagiri, Tiffani Ashley Bell, Alana Branston, Katherine Minshew, Kirsty Nathoo, Adora, Stephanie, Holly Liu, Sharon Pope, Kat Mignolet, Matthew, Carolyn
Y Combinator and a diverse panel of founders, including Jessica Livingston and representatives from Zola and Scentbird, convened to discuss scalable startup strategies that prioritize values alignment, efficient hiring, and rapid product-market fit validation. The discussion highlighted critical insights such as the dangers of bias in "culture fit" evaluations, the necessity of avoiding "crappy yeses" during fundraising, and the importance of maintaining founder-led scrappiness even after significant capital deployment. By contrasting successful pivots in sectors ranging from wedding registries to virtual data science, the event underscored that sustainable growth relies on unique founder traits and disciplined metric management rather than traditional VC heuristics or rapid scaling alone.
- Y Combinator1h 14m
Scott Aaronson on Computational Complexity Theory and Quantum Computers
Scott Aronson clarifies that quantum computing relies on choreographing destructive interference patterns to amplify correct solutions rather than simply testing all possibilities simultaneously, a capability that has shifted the field from theoretical impossibility to a rigorous engineering challenge requiring fault tolerance. He identifies the generation of untrusted random bits as a near-term application for 50–70 qubit devices and introduces shadow tomography, a technique merging differential privacy with quantum mechanics to estimate state properties efficiently. Furthermore, Aronson contextualizes these technical advances within broader computational limits regarding the P vs. NP problem, the holographic nature of spacetime, and the urgent need to align artificial intelligence with human values before addressing existential risks.
- Y Combinator26 min
Announcing Work at a Startup
Jared Friedman, Matt Long, Craig Cannon
Scheduled for July, the Work at a Startup conference reunites Y Combinator partners Justin Kahn and Sam Altman with over 80% of the accelerator's hiring companies for a scaled event featuring 35 pitches across software, robotics, and deep tech. Attendees will engage directly with startups ranging from unicorns like Instacart to early-stage hardware firms offering roles in AI, DevOps, and co-founder positions, while also viewing live hardware demonstrations from entities such as Starsky Robotics. The gathering addresses critical market trends including remote work expansion, equity transparency, and the shifting definition of startup engineering to counter traditional compensation gaps.
- Y Combinator48 min
Advice for Students and Recent Graduates on Finding Jobs – Liz Wessel of WayUp
WayUp co-founders and former Google associate product marketing manager and his partner Joel Flegelman launched their job platform after validating a user base of tens of thousands during their senior year at the University of Pennsylvania. Leveraging insights from mentor Roloff Botha and a strategic stint at Google, the duo differentiated the service from general job boards by utilizing rich, 360-degree candidate profiles to achieve a one-in-three hire rate. Today, the company operates under a distinct management philosophy that prioritizes personality alignment and skill-based hiring to help students navigate the transition into their careers.
- Y Combinator1h 19m
Simon Benjamin on Architectures for Quantum Computing
Simon Benjamin, John Preskill, Craig Cannon
Driven by experimental progress surpassing the 99% fault-tolerance threshold, Oxford University's ion trap systems now achieve 99.9% gate fidelity, enabling the first viable implementations of quantum error correction. The research team proposes a modular networking architecture that links high-fidelity units via optical fibers and entanglement purification to scale toward useful applications like molecular simulation while avoiding the engineering bottlenecks of monolithic designs. By addressing hardware limitations through this approach, the project aims to demonstrate a fully linked two-module system within a year, bridging the gap between current quantum supremacy demonstrations and future large-scale computational utility.
- Y Combinator1h 33m
John Preskill on Quantum Computing
John Preskill, Steven Hawking, Kip Thorne, Craig Cannon
Established by Richard Feynman's early theoretical work, the field of quantum computing has evolved from theoretical challenges in the 1970s to a practical reality enabled by mid-1990s error correction and recent hardware advancements in superconducting and trapped-ion systems. As current devices approach 100 qubits, they are poised to disrupt public-key cryptography through Shor's algorithm while simultaneously offering transformative capabilities in quantum chemistry simulation and materials science. The industry now focuses on bridging these applications through hybrid classical-quantum systems and developing post-quantum security measures to address the imminent threat to existing encryption standards.
- Y Combinator42 min
Mathematical Approaches to Image Processing with Carola Schönlieb
Carola Schönlieb, Craig Cannon
A researcher specializing in inverse imaging problems and partial differential equations is advancing techniques to reconstruct high-resolution medical, environmental, and historical data from severely limited measurements. By developing bi-level optimization strategies that integrate machine learning with interpretable, handcrafted mathematical models, this work addresses critical challenges in noise reduction and adversarial robustness for applications ranging from dynamic MRI imaging to the virtual restoration of illuminated manuscripts. The research successfully bridges theoretical stability guarantees with practical data-driven performance, enabling safer radiation exposure in CT scans and accurate 3D modeling of forest structures from airborne sensor data.
- Y Combinator28 min
Kieran Snyder of Textio at the Seattle Female Founders Conference
Founded in 2014 by linguists and Microsoft veterans Kieran Snyder and Jensen Harris, Textio has developed a machine-learning platform that analyzes 350 million job postings to predict engagement and reduce bias. The company recently pivoted its pricing to a flat-fee enterprise model and formed data partnerships with major clients like Amazon and Johnson & Johnson to accelerate revenue growth. With a workforce that is 50% female or non-binary, Textio aims to expand its "augmented writing" capabilities beyond HR to eventually challenge major office software providers in a planned IPO within seven years.
- Y Combinator29 min
Avni Patel Thompson at the Seattle Female Founders Conference
Seattle-based startup Poppy, founded by Avni Patel-Thompson, connects families with vetted caregivers to recreate a modern village safety net for childcare following the failure of her previous subscription box venture. After validating the concept through a low-cost pilot and recruiting a technical co-founder, the company secured Y Combinator acceptance and over $2 million in seed funding by pivoting from a membership model to a transaction fee structure. Now in a rapid growth phase with a team of ten, Poppy prioritizes mission-driven hiring and founder sustainability while aiming to help hundreds of other entrepreneurs reach validated market traction.
- Y Combinator1h 3m
Helping Landlords Find Tenants – Sean Mitchell of Rezi
Resi operates a full-risk leasing marketplace in New York and the Bay Area that transfers vacancy and tenant performance risks from landlords to itself while enabling apartment lease-ups in under ten minutes. The company funds these guaranteed upfront rent payments through a debt securitization model targeting mid-teens to 20% returns, preserving equity capital while utilizing automated underwriting to minimize discrimination. Early growth was driven by high-volume direct outreach to individual landlords, and the firm now leverages proprietary pricing algorithms to optimize unit rents ranging from $2,000 to $6,000 monthly.
- Y Combinator50 min
Crypto Investors - Linda Xie and Avichal Garg
Linda Xie, Avichal Garg, Craig Cannon, Avicil
Industry experts Avicil and Linda project that blockchain adoption will initially prioritize decentralized exchanges and digital collectibles over complex distributed applications due to current scaling limitations. The discussion highlights a trajectory where underserved regions with inflationary currencies lead mainstream integration while technical development remains concentrated in traditional hubs like Silicon Valley and Berlin. To ensure long-term viability, the speakers advocate for mandatory default privacy, rigorous investor protection mechanisms, and a shift away from public token sales toward milestone-based venture funding structures.
- Y Combinator56 min
Gaming Studio Founders - Patrick Moberg and Holly Liu
Patrick Moberg, Holly Liu, Craig Cannon
The Betaworks-founded studio Dots evolved from a minimalist art project inspired by Yayoi Kusama into a full-service game developer known for *Two Dots*, shifting its design philosophy from pure minimalism to narrative-driven Game as a Service models. The company's growth trajectory was marked by a viral Facebook ad error that drove massive initial user acquisition, followed by a strategic pivot to longer development cycles and live operations to manage rising customer acquisition costs and sustain high lifetime value. Today, the studio navigates the complexities of mobile market saturation by balancing indie innovation with specialized talent for mid-core genres, while exploring emerging technologies like AR and leveraging IP licensing to mitigate the challenges of clone competition and inflated marketing budgets.
- Y Combinator46 min
A.I. Policy and Public Perception - Miles Brundage and Tim Hwang
Miles Brundage, Tim Hwang, Craig Cannon
Researchers from the Future of Humanity Institute and Oxford University analyze the dual-use nature of artificial intelligence, categorizing risks ranging from near-term digital threats like deepfakes and adversarial attacks to long-term existential concerns. They advocate for a shift in policy from reactive measures to proactive frameworks that incorporate responsible disclosure norms, interpretability standards, and structured international cooperation to address geopolitical competition and regulatory divergence. By extrapolating technical trends rather than waiting for incidents, these experts aim to establish rigorous governance models that balance rapid deployment in fields like healthcare with the critical need for safety and value alignment.