Sami
Showing 1–2 of 2 transcripts.
- Y Combinator43 min
Aravind Srinivas: Perplexity's Race to Build Agentic Search
Aravind Srinivas, Sami, Akshat, Ravin, Angela
Perplexity AI founder Aravind Srinivasan addresses the company's rapid infrastructure strain and recurring competitive skepticism while detailing the strategic development of "Comet," an AI-powered browser designed to function as a cognitive operating system for complex agentic tasks. Differentiating itself from incumbent tech giants bound by ad-revenue models, the 200-person team leverages AI-driven engineering workflows to iterate quickly, aiming to capture direct transaction revenue through subscriptions rather than competing on traditional search advertising. Srinivasan projects a future where Perplexity maintains market relevance by prioritizing speed and human oversight in distributed systems against inevitable large-scale replication attempts from major competitors.
- Milken Institute57 min
Turning Back Time: The Science of Aging
Joanne Kenen, Nir Barzilai, Howard Fillit, Christopher Hite, Joan Mannick, Joanne Cannon, Sami, Aditi Ramdurai, San, Sarah Locke
A panel of experts led by Nir Barzilai, Christopher Healy, Howard Federoff, and Joan Manik is advocating for a paradigm shift in geroscience from treating individual chronic conditions to targeting the underlying biology of aging. The group is pursuing "healthspan compression" through concrete initiatives like the TAME metformin trial, TORC1 inhibitor development, and combination therapies designed to delay multiple diseases simultaneously. While regulatory hurdles and ethical concerns regarding long-term drug use remain, these efforts aim to prove that extending healthy life is economically viable and socially transformative.