Latest Interviews
Showing 121–135 of 548 transcripts.
Clear all filters- a16z12 min
AI Is Coming For These 3 Industries In 2026 (a16z Big Ideas)
Ryan McEntush, Angela Strange, Sarah Wang
Ryan McIntosh, Angela Strange, and Sarah Wang identify three pivotal 2026 inflection points defining the future of American industry, finance, and software architecture. These experts forecast a transition where the U.S. must vertically integrate its electro-industrial ecosystem to match China, financial institutions must abandon legacy mainframes for AI-native data systems to unlock tenfold operational scaling, and dynamic AI agent layers must displace traditional systems of record to enable autonomous execution. Collectively, these shifts emphasize that future economic and military power depends on controlling embodied electrified components, unifying data across unstructured sources, and achieving product velocity through continuous AI-driven iteration.
- a16z14 min
How AI Agents Will Transform in 2026 (a16z Big Ideas)
Marc Andrusko, Stephanie Zhang, Olivia Moore, Steph Ng
The event details a fundamental shift from reactive prompt-based interfaces to proactive AI agents that autonomously diagnose issues and execute actions, expanding the addressable market from software spending to the broader labor economy. Speakers discuss how design priorities are evolving toward machine legibility to enable high-autonomy applications in sales, security, and content discovery, while voice AI agents achieve scalable enterprise deployment in healthcare, finance, and customer service by outperforming humans in compliance and multilingual accuracy. This transition is redefining the human-in-the-loop dynamic, where critical decisions retain oversight while routine tasks are increasingly automated to drive efficiency across nearly every industry vertical.
- The Economist8 min
Why this crypto crash is different
Amidst a regulatory landscape reshaped by the Trump administration's appointment of industry insiders and the removal of past constraints, the global crypto market has matured from a niche asset class into a multi-trillion dollar financial component. Despite significant political support and the launch of family-backed ventures like World Liberty Financial, the sector is currently grappling with a unique downturn where new investors face substantial losses even as Bitcoin trades near $90,000. This shift marks a departure from historical boom-bust cycles, signaling a transition where decentralized finance aligns with conservative anti-establishment sentiments while institutional adoption accelerates through ETFs and banking licenses.
- Milken Institute6 min
LeadersLink Eszter Hars
Esther Harst, a molecular biologist and CEO of the Schwarzman-Diamond Syndrome Alliance, is deploying a patient-entered data platform to address the critical lack of "patient voice" insights in treating this rare genetic disorder that causes fatal leukemia in many patients. The initiative has secured IRB approval and is preparing to launch a pilot study to mobilize the community, facilitate clinical trial matchmaking, and catalyze global collaborations through an open architecture. Building on over 20 years of biotech experience, Harst aims to expand the program to the entire SDS community early next year after validating data utility and patient trust during the pilot phase.
- The Economist6 min
How is Russia testing the West?
Russia currently perceives itself under a continuum of low-intensity conflict with the West, interpreting Ukrainian strikes as direct aggression while employing hybrid tactics to destabilize Western democracies and undermine the existing international order. While Moscow retains high risk tolerance born of this siege mentality, recent escalations appear tempered by the fear of triggering an all-out war that would contradict its strategic goal of dismantling Western dominance. Simultaneously, China maintains a cautious distance from Russian recklessness to preserve its own economic stability, creating a complex dynamic where global powers calibrate responses to deter adversary activities without sparking accidental escalation.
- The Economist9 min
What we know about the Ukraine peace plan
Zanny Minton Beddoes, Edward Carr, Olly, Ed, Shashank, Zannie, Chris
Emerging from Geneva talks, a draft treaty to partition Ukraine has evolved from a 28-point plan to an 18-point document featuring relaxed military caps and the potential removal of constitutional bans on NATO membership. While special representative Steve Witkoff allegedly advised Russian negotiators on pressure tactics and leaked communications cast suspicion on the security of the process, key disputes remain regarding the status of Donbass, the enforceability of vague US security guarantees, and the exclusion of European military forces. Analysts warn that despite the removal of restrictive weapon bans, the proposed framework relies on unenforceable terms and creates a strategic vacuum for Ukraine's post-war defense.
- Goldman Sachs18 min
Across America with Goldman Sachs 10,000 Small Businesses
Jill Bomarito, Bill Michaels, Jenny Steffensmeyer
The Goldman Sachs 10,000 Small Businesses program functions as a strategic "mini MBA" that equips entrepreneurs like Jill Bomarito, Bill Michaels, and Jenny Steffensmeyer with the framework to transition from daily operations to high-level business management. Through this initiative, case study participants achieved significant scale by addressing critical gaps in cash flow, marketing, and leadership, resulting in sales growth ranging from 20% to tenfold and facilitating shifts from local to international markets. Beyond individual financial gains, the curriculum fosters a supportive peer network that empowers graduates to advocate for small business policy changes and secure their enterprises' long-term succession planning.
- The Economist8 min
How strong is Iran’s regime?
Nicolas Pelham, Adam Roberts, Nick, Ed
Iran's strategic pivot from a proxy-heavy "forward defense" to a missile-centric approach follows the erosion of its Syrian alliances, while the regime grapples with Supreme Leader Ali Khamenei's frailty and a shifting succession landscape dominated by factional money rather than ideology. To maintain power amidst a secular populace, the leadership is adopting nationalist narratives and rebranding the nuclear program as a permanent national asset, signaling a retreat from revolutionary theocracy. This reinvention faces an existential conflict between the public's desire for global integration and the Islamic Revolutionary Guard Corps' vested interest in preserving a closed economy that fuels its monopolies.
- Sequoia Capital10 min
From Early Failures to ‘Clash of Clans’ and ‘Brawl Stars’ - Supercell ft Ilkka Paananen
Ilkka Paananen, Maya Hoffree, Joost van Dreunen, Roelof Botha
Supercell established a unique corporate structure known as "cells" that empowers individual game teams with startup-like autonomy, a strategy that enabled leaders to cancel their initial €8 million investment in the Facebook title *Gunshine* to pivot successfully toward mobile platforms. This bold approach fostered a culture where project failures are celebrated as learning experiments, ultimately leading to the creation of industry-defining hits like *Clash of Clans* and *Hay Day* that currently command 60% of total industry playtime. Now fifteen years old, the company continues to navigate the high barrier of launching new titles by embracing increased risk-taking, aiming to emulate the century-long legacy of Nintendo or LEGO while maintaining operational excellence.
- The Economist10 min
Former IMF chief economist Gita Gopinath’s warning for rich world economies
Former IMF Chief Economist Gita Gopinath assessed the global economy from 2019 to 2025, highlighting how emerging markets demonstrated unexpected resilience against the pandemic, war, and inflation thanks to improved fiscal governance and diversified borrowing. Despite this stability, she warned of looming systemic risks including a fragile US financial sector, the opacity of non-bank lending, and a projected global debt-to-GDP ratio exceeding 100% by 2030. Addressing these challenges requires advanced economies to confront structural fiscal imbalances and aging demographics, though necessary adjustments to retirement ages face significant political resistance.
- All-In Podcast11 min
California Forever: The Startup Building America's Next Great City
Silicon Valley-backed investor Jan Sramic is advancing the California Forever project to construct a 70,000-acre self-funded community in Solano County designed to solve California's housing crisis and reindustrialize the region. The development plan features a massive advanced manufacturing park, a national shipbuilding hub on the Deepwater Ship Channel, and a walkable city intended to house 400,000 residents. By co-locating high-tech R&D with production and leveraging AI-driven robotics, the initiative aims to demonstrate American capacity for rapid construction and strategic abundance over the next two decades.
- The Economist10 min
Were we wrong about Trump's tariffs?
Zanny Minton Beddoes, Edward Carr, Henry, John, Ed
Recent trade policies have established the highest tariff levels in ninety years, creating a significant gap between announced rates and effective collection due to supply chain shifts and business cost absorption. While the U.S. economy experienced its weakest half-year growth since 2012 with rising inflation, political dynamics are shifting toward protectionism across both parties despite bipartisan opposition from key figures like Mitch McConnell. Experts warn that arbitrary policy implementation and entrenched lobbying interests will likely create long-term structural damage and market isolation, even if an immediate recession is avoided.
- All-In Podcast11 min
Bryan Johnson’s Best Health Hack: Lower Your RHR Before Sleep = Sleep Better and Live Longer
Brian Johnson presents an ambitious framework positioning the indefinite extension of human life as a new global ideology, utilizing biological age testing to illustrate that organs age independently and require targeted management. He identifies resting heart rate as the primary health metric and details a specific protocol involving strict sleep hygiene, diet timing, and screen discipline to lower this rate by approximately 10%. This approach aims to reverse aging trends while simultaneously treating sleep as the fundamental intervention for anxiety and depression, ultimately preparing humanity for a future defined by superintelligence.
- All-In Podcast19 min
Cathie Wood on How AI Can Double GDP, Bull Case for Bitcoin $1M, Elon’s Trillion-Dollar Pay Package
ARK Capital projects a near-future US GDP acceleration to 7% driven by the convergence of five innovation platforms, a trajectory that investor Cathie Wood attributes to both technological deflation and the Trump administration's tax policies. The firm forecasts a significant market broadening away from the "Mag 6" toward disruptive sectors like autonomous mobility and multi-omic healthcare, with a targeted 40–50% compound annual return for innovation equities over the next five years. Supporting this thesis, ARK maintains a bullish $2,600 price target for Tesla and a valuation model suggesting Bitcoin could reach $3.8 million, while advocating for regulatory reforms to expand private market access to retail investors.
- The Economist10 min
Who will run Gaza?
Zanny Minton Beddoes, Greg, Patrick, Zannie, Ed
Experts assess that Hamas will likely retain lighter arms while potentially depleting heavier weaponry, driven by ideological identity and fears of local reprisals. The proposed Trump peace plan outlines a corporate-style transitional authority led by President Trump and former Prime Minister Tony Blair, employing technocrats to manage civil services amid disputes between the Palestinian Authority and Hamas over governance representation. This model diverges from the Oslo Accords by prioritizing reconstruction and external pressure to shift public opinion, though recovery depends heavily on Israel allowing building materials into a territory where 80% of structures have been destroyed.