Latest Interviews
Showing 2431–2445 of 9,967 transcripts.
Clear all filters- All-In Podcast1h 34m
Bond crisis looming? GOP abandons DOGE, Google disrupts Search with AI, OpenAI buys Jony Ive's IO
Jony Ive, Chamath, Jason, Sacks
The U.S. Treasury struggled to sell $16 billion in 20-year bonds, triggering yield spikes that depressed stock indices and highlighted unsustainable debt costs driven by new tax legislation. In the technology sector, Google pivoted toward subscription-based AI search services while OpenAI acquired Jonathan Ive's firm for $6 billion to develop high-end hardware. Simultaneously, the United States launched an "AI Diplomacy" framework to secure Middle Eastern infrastructure investment, while medical breakthroughs saw the first successful in vivo CRISPR gene editing in a pediatric patient.
- Milken Institute56 min
Rising Strong: Los Angeles' Path to Recovery | Global Conference 2025
Michelle Stevenson, Elex Michaelson, Karen Bass, Lindsey Horvath, Cinny Kennard, Evan Spiegel
Hosted by the Milken Institute on January 12, a panel of Los Angeles officials and philanthropists assessed recovery efforts following the January 7, 2024 wildfires that destroyed over 16,000 structures. While Mayor Karen Bass and County Supervisor Lindsay Horvath highlighted rapid debris removal and AI-driven permit processing as key successes, the discussion also addressed systemic hurdles including insurance underwriting bottlenecks and infrastructure fragmentation across the region's 88 cities. With Governor Newsom requesting $39 billion in federal aid and philanthropists like Evan Spiegel pledging long-term support, the event emphasized balancing accelerated rebuilding timelines with rigorous safety standards and regional consolidation strategies.
- 80,000 Hours3h 35m
The bewildering frontier of consciousness in insects, AI, and more | 17 experts weigh in
Luisa, Robert Long, Jeff Sebo, Meghan Barrett, Andrés Jiménez Zorrilla, Jonathan Birch, David Chalmers, Holden Karnofsky, Bob Fischer, Cameron Meyer Shorb, Sébastien Moro, Anil Seth, Peter Godfrey-Smith, Lewis Bollard, Stuart Russell, Buck Shlegeris, Will MacAskill, Carl Shulman
A panel of leading neuroscientists and philosophers, including Megan Barrett, Robert Long, and David Chalmers, explores the ethical frameworks required to address the potential sentience of invertebrates and artificial intelligence amid profound uncertainty. Participants argue that the vast global populations of invertebrates and the theoretical possibility of conscious silicon-based systems necessitate a precautionary moral approach to prevent mass suffering and exploitation. The discussion concludes that current evidence, while inconclusive regarding a definitive "sentience score," is sufficient to warrant legal protections and the development of cooperative economic models for these potentially conscious entities.
- a16z46 min
Building AI Systems You Can Trust
Following a fifteen-year career optimizing traditional machine learning and leading AI divisions at Intel, the speaker identified that enterprise adoption of generative AI is hindered by a critical trust gap rather than a lack of raw performance. This insight drove the founding of Distributional, a platform that replaces marginal optimization with distributional testing and holistic monitoring to detect behavioral shifts in non-deterministic, agentic systems. By shifting focus from atomic metrics to continuous validation of complex workflows, the company enables organizations to centralize operations, mitigate operational risks like hallucination, and scale reliable AI applications.
- Y Combinator30 min
How To Design Better AI Apps
Pete Kuhman argues that most current AI software applications are merely legacy interfaces retrofitted with basic chat capabilities rather than being re-engineered as true "action-oriented" agents. He proposes a shift where users can customize or auto-generate system prompts to transform AI from a generic text generator into a tool that executes complex, multi-step workflows across different software environments. Supported by Y Combinator's internal implementation of such agents, this paradigm aims to replace manual prompt engineering with personalized, autonomous systems that handle routine cognitive tasks.
How Whop Is Making $1.2+ Billion For Creators
A lean engineering team of 15 to 20 staff has scaled WAP to a $1.2 billion GMV run rate and $108 million in monthly creator transactions by leveraging AI agents and a "rebuild over refactor" philosophy. Backed by high-profile investors including Peter Thiel and a16z, the platform is transitioning from a sneaker bot marketplace into a full-stack creator economy with a "Content Rewards" program driving over 5 billion views across emerging markets. The company now targets a $10 billion GMV valuation by expanding its developer ecosystem and global payment infrastructure while rejecting traditional junior engineering roles in favor of autonomous, senior-level technical leadership.
- Goldman Sachs10 min
Fade the S&P 500 rally?
Brian Garrett advises fading the S&P 500 rally by leveraging low volatility to purchase asymmetric upside calls while positioning for a potential recession through dual-digital products that profit when equities decline alongside rising yields. This strategy reflects a market divergence where soft data signals deterioration despite Goldman Sachs maintaining a 35% recession probability, creating elevated risk from upcoming geopolitical catalysts like the July tariff clock. Consequently, investors are hedging against a critical 5% to 6% yield threshold that could trigger significant equity outflows, particularly as retail capital becomes increasingly sensitive to upcoming labor data.
- Dwarkesh Patel2h 24m
Is RL + LLMs enough for AGI? — Sholto Douglas & Trenton Bricken
Sholto Douglas, Trenton Bricken
By 2025, advanced reinforcement learning with verifiable rewards is expected to enable software engineering agents to match junior human output, though they will still struggle with long-horizon, amorphous tasks due to memory and context limitations. Concurrently, mechanistic interpretability research is mapping internal neural circuits to distinguish genuine reasoning from heuristic guessing, while safety studies reveal critical fragility in model alignment during fine-tuning and evaluation contexts. Despite these capabilities, the industry faces looming bottlenecks from GPU supply and energy constraints that may dictate the pace of intelligence scaling, necessitating strategic shifts toward infrastructure investment and economic adaptation.
- Milken Institute1h 1m
Addressing the Financial Headwinds Faced by Gen Z and Millennials | Global Conference 2025
Cheryl Evans, Kahlil Byrd, Catherine Collinson, Alexis Crow, Dorothy Kelly, Sylvia Kwan
A diverse panel of financial experts from institutions including Ellevest and the Transamerica Institute examines the distinct economic headwinds facing Gen Z and Millennials, highlighting a severe wealth gap where Baby Boomers control 65% of assets against 13% for younger generations. The discussion details how structural shifts in the economy, rampant student loan defaults, and AI-driven job transformations are eroding intergenerational mobility and forcing many young adults into precarious financial positions due to caregiving duties. Panelists recommend immediate industry interventions such as employer-integrated debt-to-wealth platforms and personalized financial education to mitigate the risk of long-term wealth stagnation as the Great Wealth Transfer progresses.
Rippling vs. Deel Lawsuit: WTF Happens Now? The Future of the Late Stage Private Market
Rory O'Driscoll, Jason Lemkin, Harry Stebbings
The Chime S1 filing reveals an expected IPO valuation of $10 billion to $12 billion, a significant drop from its $25 billion private peak driven by regulatory reliance on the Durbin Amendment and potential investor ratchet protections. This event reflects broader venture market shifts where financial services firms prioritize public listings for scalable capital while AI adoption threatens traditional SaaS moats by commoditizing core applications. Concurrently, corporate strategies are pivoting toward aggressive settlements in legal disputes and structural transitions like OpenAI's move to a Public Benefit Corporation to navigate governance and profitability challenges.
- Goldman Sachs22 min
A world of opportunity: Rob Citrone’s best ideas
Rob Citrone, Tony Pasquariello
Discovery Capital Management founder Robert Citrone outlines a macro strategy delivering 50% annual returns in 2023 and 2024, driven by high-conviction short positions in U.S. regional banks and a bullish thesis on Latin American markets. Citrone forecasts a "fake recession" in the U.S. before a 2026 boom fueled by tax cuts, predicting higher Treasury yields and resisting near-term Fed rate cuts while championing Argentina's fiscal reforms as a prime investment opportunity. The firm combines Julian Robertson's stock-picking with George Soros's risk management, leveraging a unique 24-hour trading cycle and direct global policy access to capitalize on emerging political shifts and market inefficiencies.
- The Diary Of A CEO1h 47m
Alcohol Rewires Your Brain - Dr. Sarah Wakeman
Harvard professor Dr. Sarah Wakeman presents a comprehensive analysis of alcohol and drug use disorders, dismantling the myth of safe consumption thresholds while identifying trauma and isolation as primary drivers of addiction. She argues for a paradigm shift from punitive measures to chronic disease management, highlighting evidence-based treatments like medication-assisted therapy and psilocybin that target the neurobiology of craving. Ultimately, her mission is to reframe addiction as a treatable condition with a high prognosis, emphasizing that recovery relies on connection, community, and long-term care rather than willpower or "hitting bottom."
- All-In Podcast29 min
Antonio Gracias: DOGE updates, Voter fraud, Finding 'Big Balls' | All-In Live from Miami
Antonio Gracias, Chamath, Jason, Friedberg, David Sacks
Antonio Gracias leads a Doge team implementing a zero-defect operational overhaul of the US government bureaucracy, targeting a 15% reduction in waste and fraud by eliminating NGO spending and restoring full office productivity. The administration combines aggressive voter fraud detection using restored SAVE database protocols with a meritocratic recruitment strategy that prioritizes problem-solving over credentials to secure high-caliber engineering talent. This approach supports a dual-track immigration policy that balances open borders for skilled professionals with strict border sovereignty measures and temporary public service models.
- Milken Institute59 min
The Roadmap to Longevity | Global Conference 2025
Gadi Schwartz, Dan Buettner, Laura Deming, Richard Isaacson, Eric Verdin, Vonda Wright
Panels including Dan Buettner, Laura Deming, and Dr. Eric Verdin emphasized a paradigm shift from extending mere life span to maximizing health and brain span through lifestyle interventions that determine 93% of longevity outcomes. While no single "hack" exists, experts project that combining optimized nutrition, walkable urban design, and emerging precision medicine could push healthy life expectancy to 90–95 years, with the first FDA-approved longevity drug anticipated within the next five years. Despite this potential for breakthrough therapies, the consensus highlights a critical funding crisis threatening US biomedical research and calls for systemic reforms to democratize access to preventive care rather than reactive sick care.
- Goldman Sachs25 min
Is Fed independence at risk?
Richard Clarida, John Cochrane, Alison Nathan
The Trump administration is actively pursuing legal challenges to overturn the *Humphrey's Executor* precedent, aiming to eliminate "for-cause" protections for Federal Reserve officials and subject them to direct presidential removal. While structural checks like the Federal Open Market Committee's voting system and Senate confirmation remain, this strategy threatens to destabilize financial markets by introducing uncertainty over the central bank's ability to maintain price stability. Experts warn that removing these independence safeguards could distort inflation expectations and encourage mission creep, as the Fed faces pressure to expand beyond its statutory mandate into areas like climate risk and housing policy.