Latest Interviews

The Future Will Be Genetically Engineered

Alec Nielsen

Asimov, a Cambridge-based company founded by Alec, is redefining biotechnology by merging software engineering with biology to create living systems that function as advanced molecular nanotechnology. Building on a history of genetic milestones ranging from insulin production to CRISPR-like therapies, the firm utilizes machine learning and computer-aided design to develop next-generation therapeutics, such as personalized cancer vaccines, and future applications including sustainable manufacturing and space exploration. This shift from manual genetic manipulation to computational genome design aims to overcome biological complexity, positioning engineered biology as a ubiquitous infrastructure comparable to integrated circuits.

The Latest in Cyber Attacks

Martin Casado

A strategic shift in the cybersecurity landscape has redirected attacker focus from costly corporate systems to individuals, driven by the economic disparity where compromising an account costs $100 versus millions for device exploits. This pivot has enabled a $26 billion Business Email Compromise industry relying on social engineering and physical access vectors like SIM porting, which recently compromised high-profile targets such as Jack Dorsey. To counter these threats, experts advocate a defense stack combining hardware-stored security keys, password managers, and physical security measures like smart surveillance to restore organizational herd immunity.

Afghanistan: why the Taliban can't be defeated

Marking the longest war in American history, the nearly two-decade conflict in Afghanistan has left the nation in ruin with the Taliban controlling significant territory despite decades of US military intervention and diplomatic efforts. While previous administrations deployed varying troop levels and fostered temporary democratic gains, the insurgency remains resilient, fueled by local grievances, Pakistani support, and a booming opium trade that funds 90% of the world's heroin. Ultimately, the transcript concludes that sustainable peace requires a genuine power-sharing agreement among Afghan factions rather than rushed withdrawals or fragile deals, as the international community must prioritize patient diplomacy to prevent a Taliban takeover.

YC SUS: Eric Migicovsky hosts founder office hours

Eric Migicovsky, Eric Mijakovsky, Helen, Drow, Philippe, Diana, Bill, Jason Hirschhornbecker

Five software founders presenting Jovial, Cognitive, Match Hotels, DreamList, and Burlocks received targeted strategic advice to refine their business models and overcome specific operational hurdles such as low conversion rates and scalability challenges. The session emphasized executing concrete two-week action plans, including manual outreach to secure annual subscriptions, niche market testing, and pivoting from manual services to scalable software products. By defining clear success metrics and shifting revenue strategies from one-time fees or unreliable affiliate tracking toward recurring revenue, these entrepreneurs aim to validate their product-market fit and drive sustainable growth.

Matt Might: The Algorithm for Precision Medicine

Matt Might, Matt Mite

Matt Mite, director of the Hugh Call Precision Medicine Institute at UAB, leverages computational optimization and a knowledge graph of 30 million abstracts to derive actionable precision medicine strategies for patients with undiagnosed genetic disorders. His approach, exemplified by the successful treatment of his son Bertrand's NGLY1 deficiency and the identification of Prevacid for ion channel epilepsies, prioritizes logical mechanism proofs to overcome physician skepticism and legal liability. Through an undergraduate-led workflow and the "All of Us" initiative, Mite's institute continues to transform complex genomic data into targeted interventions, from drug repurposing to novel metabolic pathways, asserting that scientific experimentation always yields actionable solutions.

YC SUS: Gustaf Alströmer and Eric Migicovsky discuss growth tactics

Gustaf Alströmer, Eric Migicovsky, Gustav

This comprehensive analysis outlines critical strategies for early-stage startups, emphasizing that charging users immediately is essential for validating product-market fit and sustaining growth. Founders are advised to prioritize direct customer engagement and curated supply acquisition while leveraging predictive retention metrics and substantial referral incentives to drive scalable adoption. The guidance further details how to navigate market education through targeted SEO and social proof, ensuring that monetization models align with user value rather than relying on unsustainable advertising revenue.

A Conversation with Strive Masiyiwa and Michael Milken

Strive Masiyiwa, Michael Milken

With Africa's population projected to reach 4 billion by 2100 and 12 million young entrants joining the workforce annually, the continent faces a critical imperative to modernize its fragmented economy and address high unemployment rates like the 29% in South Africa. Global tech giants and investors are capitalizing on unique innovations such as mobile money and blockchain to unify 54 currencies, while infrastructure projects connect the continent from Cape Town to Cairo alongside rapid 5G deployment. Strategic partnerships led by figures like Strive Maseiwa aim to train government leaders and expand private enterprise networks, positioning Africa as a primary future market despite capital shortages and the need to replace nearly 500 million traditional jobs.

Mic'd Up - Part 2:Genomics & the Future of Medicine

Rick Berke, Phil Febbo, Anamika Mehta, Rakesh Suri

The event details how advanced viral defense mechanisms, culturally attuned facility designs, and rapidly declining genomic sequencing costs are reshaping clinical precision medicine, with specific case studies highlighting Cleveland Clinic Abu Dhabi's successful integration of these technologies. Key speakers analyze the friction caused by fragmented U.S. payers and electronic health records while contrasting these challenges with the streamlined adoption seen in the UK and the UAE's population-specific cancer initiatives. The discussion concludes with a strategic roadmap for the next decade that emphasizes decentralized care, robust data privacy protocols, and AI-driven analytics to transform genomic insights into actionable, personalized patient outcomes.

Mic'd Up - Part 1: Public Health Response to Coronavirus

Christopher Mores, Rick Berke

This expert panel discusses the emerging COVID-19 outbreak, noting its official WHO naming to prevent stigmatization, approximately 45,000 confirmed cases primarily in China, and the critical lack of international access due to data transparency concerns. Speakers analyze divergent future scenarios ranging from endemic circulation to a global pandemic with a 2% fatality rate, while critiquing delayed WHO leadership and insufficient vaccine development timelines that may exceed a year. The discussion further addresses necessary public health strategies, including social distancing over universal masking, the economic risks of draconian travel restrictions, and the urgent need for rapid diagnostic deployment amid funding cycles that previously hampered preparedness.

Lunch Program - Part 2: The New Age of Consumerism

Hadley Gamble, Mohammed Alshaya, Mike Novogratz, Dan Murphy, Mohamed Alshayer

At the Milken Institute Middle Eastern Africa Summit, moderated by CNBC's Dan Murphy, Alshaya Group Executive Chairman Mohamed Alshayer and Galaxy Digital CEO Mike Novogratz discussed the strategic evolution of the modern consumer market. They highlighted how brands must pivot toward experiential value, digital integration, and authentic storytelling to capture the loyalty of Millennials and Gen Z, citing Alshaya's aggressive five-year, $5 billion investment plan in Saudi Arabia as a primary example of regional expansion. The dialogue further explored the rising influence of celebrity-driven viral marketing and the accelerating institutional acceptance of cryptocurrency, with both leaders advocating for adaptive business models that embrace ESG principles and technological innovation.

Lunch Program - Part 1: Well Being in the Digital Era

Deepak Chopra, Paris Hilton, Louise Tabbiner

Milken Institute CEO Michael Clowden hosted a dialogue between physician Deepak Chopra and Paris Hilton that examined the intersection of personal storytelling, social media archetypes, and modern well-being. The conversation explored how Hilton leveraged her television persona to build a multi-billion dollar empire while Chopra advocated for a philosophy of success rooted in inner purpose rather than traditional ambition. The session concluded with Chopra guiding the audience through a meditation framework designed to enhance self-awareness and manage stress through specific breathing techniques and reflective inquiry.

Venture Capital: The Rise of the Rest

Fahad AlSharekh, Ibrahim Ajami, Avi Eyal, Sarah Kunst, Jack Selby, Pule Taukobong

Leading venture capitalists from the Middle East and Africa, including representatives from Mubadala, Entree Capital, and Teal Capital, discuss a surge in regional capital inflows and the shift toward deep-tech sectors like AI and semiconductors. Despite persistent talent shortages and infrastructure gaps, panelists identify emerging local funds as critical gatekeepers that will validate startups before attracting tier-one international follow-on capital. Strategic partnerships are forming to foster founder-centric cultures and build indigenous expertise, positioning these frontier markets for potential growth that may soon outpace traditional U.S. and European hubs.

The Future of Banking

Dan Murphy, Elissar Farah Antonios, Steve Jacobs, Sunil Kaushal

Industry experts at the "Future of Banking" summit concluded that traditional financial institutions must integrate with fintechs and Big Tech rivals to survive a shift from product silos to data-driven platforms. Case studies from BTG Pactual and Citi illustrated how strategies like tokenization, internal innovation challenges, and leadership exposure to tech hubs can drive market growth and cultural agility. Despite these disruptions, the event emphasized that incumbent banks retain a significant valuation advantage over digital-native competitors while navigating regulatory hurdles and the need for massive cybersecurity investment.

Morning Program - Opportunity in the Middle East: A Road Less Traveled

Michael Clowden, John Riccolta, Mina al-Arabi, Khaled El-Romehi, Mohamed El-Ardi, Abdullah Zamil

At the Milken Institute MIA Summit in Abu Dhabi, regional leaders and experts from the UAE, Bahrain, and Saudi Arabia outlined a collective strategic pivot from hydrocarbon dependence toward diversified, knowledge-based economies driven by demographic youth bulges and technological innovation. Key speakers highlighted specific success models, such as Bahrain's telecommunications deregulation and Saudi Arabia's Vision 2030 initiatives like NEOM, while emphasizing the critical need for robust intellectual property laws and regulatory frameworks to attract foreign direct investment. The discussions concluded that navigating fiscal constraints and geopolitical volatility requires governments to transition from primary employers to regulators, fostering private sector competition to absorb the growing workforce and achieve long-term stability.

A Conversation with Leon Black

Leon Black, Sherwood Dodge

Founded by Leon Black three decades ago, Apollo Global Management now directs $350 billion in assets across 18 global offices using a diversified "fund for all seasons" strategy that spans private equity, private credit, insurance, and real assets. The firm distinguishes itself by targeting an average acquisition multiple of 6x EBITDA and prioritizing complexity arbitrage in corporate carve-outs and distressed scenarios, while shifting 80% of capital into long-duration structures to mitigate fundraising pressure. Facing a market where public valuations discourage long-term planning, Apollo is actively deploying capital into public-to-private transactions and emerging sectors like aviation finance with the goal of generating 8–10% returns in credit platforms over the coming years.