Latest Interviews
Showing 5596–5610 of 9,980 transcripts.
Clear all filters- All-In Podcast1h 36m
E73: Late-stage VC markdowns and mistakes, market strategy, Ukraine/Russia update with Brad Gerstner
Brad Gerstner, Friedberg, Zelenskyy, Putin, Biden, Zakaria, David Sacks
Brad Gershner, Chamath Palihapitiya, and David Sacks analyze the transition from the 2020–2021 bull market to a normalization phase driven by rising real rates, predicting 50–60% mispricing in late-stage venture valuations and widespread down-round IPOs. The panel introduces the "burn multiple" as a critical governance metric to enforce capital efficiency, while simultaneously warning that geopolitical strategies in Ukraine and a potential US-China recession could exacerbate the upcoming economic downturn. These macroeconomic shifts and valuation corrections are contextualized alongside the upcoming All-In Summit in Miami, where confirmed speakers will address the necessity of stripping away speculative excesses to rebuild resilient business models.
- Goldman Sachs16 min
How Policymakers are Navigating Stagflation Risk
Eric Rosengren, Philipp Hildebrand, Jan Hatzius, Alison Nathan
Economists Eric Rosengren and Philip Hildebrand warn that the U.S. and Euro Area face heightened stagflation risks driven by multi-decade inflation levels and supply shocks from the Russia-Ukraine conflict. While the Federal Reserve is criticized for being behind the curve in raising rates, strategies involving balance sheet recalibration are debated to avoid a policy-induced recession predicted by Goldman Sachs analysts. Policymakers remain compelled to continue tightening to anchor inflation expectations, even as forecasts suggest a shallow normalization cycle and a growth slowdown to approximately 2%.
- The Economist11 min
War in Ukraine: is a peace deal possible?
Ongoing negotiations between Kyiv and Moscow remain stalled over the core triad of territorial status, sanctions sequencing, and Crimea's strategic corridor, as Russian Foreign Minister Lavrov lacks final authority to offer concessions without President Vladimir Putin's direct approval. While Ukraine has hardened its stance by rejecting pre-1991 borders and exploring security guarantees akin to Finnish neutrality, Putin's strategy is increasingly driven by domestic consolidation rather than genuine security needs, reflecting a calculated worldview that prioritizes legacy over realistic military outcomes. This strategic deadlock, compounded by Putin's internal miscalculation and the reluctance of his kleptocratic inner circle to risk nuclear escalation, leaves both sides facing a stalemate with no substantive progress toward a comprehensive peace deal.
- The Diary Of A CEO1h 4m
Diplo: College Dropout To World's Most Iconic DJ | E128
Diplo recounts his transition from a homeless dropout to a self-taught music mogul who pioneered mashup culture and mainstreamed dancehall by leveraging strategic niche marketing and relentless work discipline. Facing the psychological toll of the industry and the premature deaths of peers, he has recently shifted toward prioritizing family mental health and structural stability while preparing a 2024 solo album focused on pop songwriting and master rights ownership. His narrative serves as a critique of modern music logistics and a blueprint for sustainable creativity, emphasizing that his true legacy lies in fostering emotional connections rather than merely accumulating commercial success.
- Goldman Sachs18 min
Gene Editing: The Future of Genomic Medicine & Biotech Investing
Salveen Richter, Allison Nathan, Selvine Richter
Gene editing distinguishes itself from traditional gene therapy by utilizing molecular scissors like CRISPR-Cas9 to permanently correct genetic defects in liver, eye, and neurological applications, with recent ex vivo successes for sickle cell disease and the first in vivo proof-of-concept for TTR. As two CRISPR-based therapies approach regulatory filings in 2022 and pivotal studies advance for rare diseases, the industry faces rigorous FDA safety mandates requiring fifteen years of follow-up data alongside complex reimbursement challenges stemming from the high one-time cost of curative treatments. While significant venture capital and pharmaceutical acquisitions drive the integration of next-generation tools like base and prime editing, the field maintains a strict consensus against germline modifications to mitigate ethical concerns and long-term safety risks.
- Lex Fridman1h 47m
Ariel Ekblaw: Space Colonization and Self-Assembling Space Megastructures | Lex Fridman Podcast #271
MIT's Ariel Ekblot and her startup, the Aurelia Institute, are pioneering autonomous, self-assembling space architecture to enable sustainable human settlement in orbit. Her research utilizes magnetically bonded "Tesserae" tiles and swarm robotics to construct large-scale, artificial gravity habitats while prioritizing decentralized "space cities" over planetary surface colonization. Beyond structural engineering, Ekblot emphasizes the integration of social robotics, psychological support systems, and transparent public engagement to ensure the long-term viability and democratization of humanity's expansion into deep space.
- Goldman Sachs28 min
Russell Wilson, Denver Broncos Quarterback; Super Bowl XLVIII Champion
Russell Wilson, Nicole Pullen-Ross
Nine-time Pro Bowl quarterback Russell Wilson leverages a decade of NFL records and his unique background in baseball and basketball to challenge conventional athletic and business limits. Wilson applies his "neutral thinking" philosophy and strategic risk management to build a diverse portfolio including West to East and the Good Man Brand while directing the Why Not You Foundation to distribute over 70 million meals. Looking forward, he aims to redefine the potential of professional athletes by prioritizing immediate excellence and community leadership over traditional career trajectories.
- The Economist13 min
Sustainable materials: is there a concrete solution?
Nareed, Mazamel, Chris Cheeseman, Michael Ramage
Driven by intensifying extreme weather and the construction sector's 11% share of global carbon emissions, experts are evaluating alternatives to traditional concrete such as Bettila's industrial waste-based cement, hempcrete insulation, and Cambridge University's engineered Cross-Laminated Timber. While these materials offer significant emission reductions and prefabrication efficiencies, their widespread adoption faces hurdles including scalability limits for waste-derived products, mechanical strength constraints for heavy infrastructure, and high upfront costs that conflict with homeowner budgets. As urbanization pushes the global population to 68% by 2050, consumer market pressure remains the primary catalyst for transitioning toward these lower-carbon building solutions despite persistent technical and financial barriers.
- Goldman Sachs40 min
Eric Adams, Mayor of New York City
New York City Mayor Eric Adams is redefining the city's governance by forging a corporate covenant to accelerate economic recovery and establishing strict performance metrics for agencies like the FDNY and Department of Buildings to reduce bureaucratic delays. To create a foundation for prosperity, his administration is simultaneously addressing public safety through a dual strategy of enforcement and root-cause intervention while launching major infrastructure initiatives such as a new onshore wind port and a Brooklyn-based Cyber Command Center. Anchored in his former law enforcement experience, Mayor Adams aims to transform the city into a globally business-friendly hub that balances fiscal innovation with social cohesion and public health resilience.
- Goldman Sachs29 min
Tricia Glynn, Managing Director at Advent International
Managing Director Tricia Glenn outlines Advent's investment philosophy, which prioritizes revenue growth and seeks three-to-fivefold returns by partnering with consumer retail disruptors rather than focusing on cost-cutting. She details how the firm navigates a shifting 2022 macro landscape driven by supply chain disruptions and rising interest rates by targeting "pearls" with exceptional talent and capitalizing on the live-selling revolution. Glenn further emphasizes the necessity of systemic diversity and risk-taking to secure actual power for underrepresented leaders, citing portfolio successes like Olaplex and Lululemon as evidence that aggressive capital deployment drives industry inflection.
- The Diary Of A CEO1h 33m
Jaackmaate: The Untold Story Of My Battle With Health Anxiety & OCD | E127
In a candid reflection on his career and personal life, YouTuber Jack Mate details how a difficult upbringing and severe OCD shaped his transition from viral comedy to authentic long-form podcasting on Spotify. Despite achieving financial milestones like paying off his house, Mate navigates a "Rival Fallacy" that has replaced his early dopamine with a search for purpose through deeper connections and stand-up comedy. His current strategy prioritizes meaningful content and family support over algorithmic ad revenue, marking a strategic shift away from the "cancel culture" persona that once defined his mainstream YouTube success.
Sid Sijbrandij: How I Founded GitLab; Remote Work vs In-Person; CEO Coaches | 20VC
GitLab CEO Sid Sijbrandij outlines the evolution of his fully remote DevOps platform, detailing how a 2,000-page handbook and mandatory informal "coffee chats" enable asynchronous collaboration across 60 countries while mitigating the fragmentation risks inherent in hybrid work models. Beyond internal operations, Sijbrandij advocates for a unified DevOps market and shares governance strategies involving situational leadership and specialized board feedback to support the company's growth from 300 to over 1,500 employees. The discussion concludes with insights into OpenCore Ventures, a new initiative aiming to build open-source companies around core projects, as the organization navigates the scaling challenges of cross-functional initiatives.
- All-In Podcast1h 15m
E72: Impact of sanctions, deglobalization, food shortage risks, macroeconomic outlook and more
Jason, Sacks, Chamath, DavidSacks, Friedberg, TheZachEffect, Biden
Experts at a recent panel debate analyzed the Ukraine-Russia conflict's potential for a near-term ceasefire based on neutrality and territory concessions, while warning that Western overconfidence could delay a settlement. The discussion highlighted how the war threatens global food security by disrupting grain exports and exploding fertilizer costs, creating a feedback loop that could push over 100 million additional people into starvation. Furthermore, the event outlined a structural shift in global economics toward supply chain redundancy and a "Cold War II" dynamic where Russia strengthens its reliance on China amid high inflation and geopolitical fragmentation.
- The Economist25 min
Gene editing: should you be worried?
James Dale, Isla Mirada, Natalie Kofler, Emmanuelle Charpentier, Jennifer Doudna, Josh Lehrer, Denis Rebrikov, Theresa Blankmeyer-Burke, He Zhongkui, George Church
Recent advancements in CRISPR and gene editing have accelerated scientific capabilities for curing terminal diseases, securing food supplies against extinction events like the banana fungus TR4, and controlling disease vectors, yet these tools introduce significant ethical risks regarding bio-warfare, social inequality, and the potential for designer humans. While regulatory frameworks vary globally between the strict bans in Europe and the more permissive approaches in the US and Japan, controversies persist over transparency in field trials and the morality of germline editing, as highlighted by critiques from bioethicists regarding community consent and the normalization of de-extinction projects. Ultimately, experts warn that without robust, transparent governance to balance rapid innovation with safety, humanity risks undermining public trust while failing to leverage these essential technologies to mitigate climate change and ensure future food security.
- The Diary Of A CEO1h 28m
Israel Adesanya: Becoming World Champion Was The Lowest Day Of My Life!
Israel Adesanya, Stephen Bartlett
UFC champion Israel Adesanya discusses how his early experiences with racism and trauma shaped his philosophy on masculinity, mental hygiene, and the distinction between lasting legacy and temporary fame. Drawing from his career highs and lows, including a 2013 personal crisis, he details his strategies for coping with imposter syndrome, managing public scrutiny, and utilizing martial arts to tame primal aggression. Adesanya further outlines his future plans to reform education through homeschooling and expand philanthropy, emphasizing the importance of owning one's identity without seeking external validation.