Latest Interviews
Showing 8281–8295 of 9,951 transcripts.
Clear all filters- Y Combinator1h 14m
Fermat's Library Cofounders João Batalha and Luís Batalha
João Batalha, Luís Batalha, Mika, Timor, Francesc Campoy Flores, Mark Mandelmann
Fermat's Library is a browser-based platform founded by four MIT alumni that enables researchers to annotate academic papers using LaTeX and Markdown to simulate an offline journal club experience. The team has grown the site by hosting over 1,000 documents, including the most commented-on Bitcoin whitepaper, and deployed a Chrome extension for arXiv to facilitate real-time collaboration on preprints. By promoting open science principles and addressing systemic issues like the lack of incentives for negative results, the platform aims to evolve into a global "Stack Overflow for science" that supports peer review and knowledge discovery outside traditional paywalls.
- The Economist10 min
Can eco-tourism help save the ocean?
In Indonesia's Coral Triangle, the Mizzul Marine Protected Area transitioned from a poached wasteland to a thriving ecosystem through a private-enterprise model founded by Andrew and Marit Miners. This initiative employs over 200 locals in conservation and tourism roles, utilizing ocean rangers to enforce a no-take ban that has boosted shark populations by 25 times and increased marine biomass by 600%. By generating revenue that exceeds former fishing income, the project demonstrates a scalable financial argument for biodiversity protection that local communities now control.
- Milken Institute59 min
Artificial Intelligence and Machine Learning in Medicine: Hope or Hype?
Rick Berke, Rowan Chapman, Iya Khalil, Lloyd Minor, George Yancopoulos, Megan Zweig, Dan Furstenberg
Industry leaders and researchers convened to address the critical bottleneck of poor data quality in healthcare AI, noting that high-quality "big data" is essential for overcoming the limitations of existing Electronic Health Records and avoiding failures like those seen with IBM Watson. While venture capital has pivoted from high-risk clinical decision support to near-term applications in operational efficiency and medical imaging, participants advocated for long-term systemic reforms such as FDA mandates for molecular data collection and a $200 million biobank initiative to enable precise patient phenotyping. The panel concluded that bridging the gap between clinical trial success and real-world outcomes requires rigorous regulatory frameworks and collaborative investment to reduce physician burnout and improve drug development success rates.
- Goldman Sachs26 min
Episode 87: The Rate Stuff: What Markets Are Saying About the Macro Outlook
Francesco Garzarelli, Jake Seward
Goldman Sachs Research analysts attribute current equity and bond volatility to a market repricing of U.S. growth following fiscal stimulus, while forecasting four Federal Reserve rate hikes in 2018 that align with a terminal rate near 3%. The firm contends that a synchronized global bond bear market is unlikely until late 2018 or 2019, noting that divergent central bank cycles currently limit systemic risk despite rising term premiums in Europe and Japan. To capitalize on expected market complacency regarding inflation, the strategy advocates maintaining exposure to risky assets while exploiting volatility premiums through steeper yield curves.
- Y Combinator3h 39m
Female Founders Conference - New York
Jessica Livingston, Kathryn Minshew, Alex Cavoulacos, Mariya Nurislamova, Reshma Shetty, Shan-Lyn Ma, Reham Fagiri, Tiffani Ashley Bell, Alana Branston, Katherine Minshew, Kirsty Nathoo, Adora, Stephanie, Holly Liu, Sharon Pope, Kat Mignolet, Matthew, Carolyn
Y Combinator and a diverse panel of founders, including Jessica Livingston and representatives from Zola and Scentbird, convened to discuss scalable startup strategies that prioritize values alignment, efficient hiring, and rapid product-market fit validation. The discussion highlighted critical insights such as the dangers of bias in "culture fit" evaluations, the necessity of avoiding "crappy yeses" during fundraising, and the importance of maintaining founder-led scrappiness even after significant capital deployment. By contrasting successful pivots in sectors ranging from wedding registries to virtual data science, the event underscored that sustainable growth relies on unique founder traits and disciplined metric management rather than traditional VC heuristics or rapid scaling alone.
- Y Combinator1h 14m
Scott Aaronson on Computational Complexity Theory and Quantum Computers
Scott Aronson clarifies that quantum computing relies on choreographing destructive interference patterns to amplify correct solutions rather than simply testing all possibilities simultaneously, a capability that has shifted the field from theoretical impossibility to a rigorous engineering challenge requiring fault tolerance. He identifies the generation of untrusted random bits as a near-term application for 50–70 qubit devices and introduces shadow tomography, a technique merging differential privacy with quantum mechanics to estimate state properties efficiently. Furthermore, Aronson contextualizes these technical advances within broader computational limits regarding the P vs. NP problem, the holographic nature of spacetime, and the urgent need to align artificial intelligence with human values before addressing existential risks.
- The Economist38 min
James Comey on emails, the "American giant" and the end of Donald Trump
James Comey, Donald Trump, Anne McElvoy
Former FBI Director James Comey articulates his judgment that President Trump is morally unfit for office while asserting the FBI remains a rock-solid, unpoliticized institution despite intense scrutiny. He reflects on the contentious October 28 decision regarding the Clinton email investigation and expresses skepticism about the North Korean denuclearization deal, maintaining high confidence that the Mueller probe will uncover criminal facts regardless of political fallout. Looking ahead to his public policy course at the College of William & Mary, Comey emphasizes that ethical leadership is defined by rigorous truth-seeking processes rather than outcomes, arguing that American democratic values may ultimately strengthen through a necessary national reassessment.
- Goldman Sachs32 min
Talks at GS: Malcolm Gladwell on the Art of Storytelling – From Print to Podcasts
In this wide-ranging discussion, Malcolm Gladwell explains how the immersive nature of podcasting enabled him to transition from print journalism to the non-fiction series *Revisionist History*, where he explores counterproductive outcomes by well-intentioned people. He details specific investigations into the University of Pennsylvania football scandal, the economic paradox of private country clubs, and the NIH's innovative response to the AIDS epidemic while defending the ad-supported audio model. Finally, Gladwell outlines the central thesis of his upcoming book *Talking to Strangers*, which examines the "default to truth" bias through the lens of the Madoff scandal and discusses his personal views on academic research and standardized testing.
- Goldman Sachs14 min
Deborah Jackson and Davida Herzl: Advancing the Future of Women Entrepreneurs
Deborah Jackson, Davida Herzl, Stephanie Cohen
Plum Alley Investments, founded by Deborah Jackson, targets Series A female-founded technology companies like Davida Herzl's Aclima by providing capital and strategic support to address the systemic capital gap for women in hard tech. This venture capital firm prioritizes ventures with validated products and societal impact, operating with an investment thesis that diverse leadership correlates with superior financial returns and global innovation. Through an active partnership model where members commit $1.5 million or more annually, Plum Alley aims to establish a replicable template proving that women-led investing and companies can achieve both massive market impact and exceptional profitability.
- Milken Institute1h 0m
Entitlements: A Collision Course With Fiscal Reality
Josh Barro, Jared Bernstein, Andrew Biggs, Chris Hughes, Maya MacGuineas, Eric Schmidt, Andrew McAfee, Jonathan Zittrain, Jared King, Nancy Gertner, David Rockefeller, Anne Coughlin, Eric Schwartzman
A panel of experts including Andrew Biggs and Jared Bernstein addressed the actuarial insolvency of Social Security and Medicare, evaluating revenue increases and benefit adjustments to close the projected 75-year shortfall. The discussion extended to expanding income support through a modernized Earned Income Tax Credit while contrasting these proposals with healthcare reforms aimed at reducing drug costs and leveraging public options. Panelists concluded that political constraints and intergenerational inequities currently prevent necessary fiscal adjustments, creating a gap between public demand for services and willingness to fund them.
- Y Combinator26 min
Announcing Work at a Startup
Jared Friedman, Matt Long, Craig Cannon
Scheduled for July, the Work at a Startup conference reunites Y Combinator partners Justin Kahn and Sam Altman with over 80% of the accelerator's hiring companies for a scaled event featuring 35 pitches across software, robotics, and deep tech. Attendees will engage directly with startups ranging from unicorns like Instacart to early-stage hardware firms offering roles in AI, DevOps, and co-founder positions, while also viewing live hardware demonstrations from entities such as Starsky Robotics. The gathering addresses critical market trends including remote work expansion, equity transparency, and the shifting definition of startup engineering to counter traditional compensation gaps.
- Goldman Sachs21 min
Dan Abrams: Trial in American Life: Cases That Have Shaped the Nation
Dan Abrams, founder of Abrams Media and Chief Legal Anchor for ABC News, leverages his background in constitutional law and trial coverage to advocate for televised proceedings while producing complex legal analysis for public consumption. His work spans the creation of "Law and Crime," the co-authorship of *Lincoln's Last Trial*, and the production of the high-rating show *Live PD*, all designed to clarify legal systems through immersive storytelling and historical context. By prioritizing accessible "airport questions" over technical jargon, Abrams aims to improve public understanding of justice while countering the perceived risks of media influence on courtroom integrity.
- Goldman Sachs45 min
Paul Tudor Jones: Investing in a More “JUST” World
Paul Tudor Jones, Lloyd Blankfein
Hedge fund legend Henry Jones, following his 1980 founding of Tudor Investment Corp, warns of impending market corrections driven by derivative structures, negative real interest rates, and unsustainable fiscal policies that mimic the 1987 crash. Leveraging his insights on economic volatility, Jones has shifted his focus to social impact by launching the Robin Hood Foundation and co-founding Just Capital to redefine corporate success through public-prioritized metrics like employee treatment and customer care. His research demonstrates that companies adhering to these "just" principles outperform traditional benchmarks while simultaneously addressing wealth inequality and poverty, proving that ethical practices can generate superior financial alpha.
- Goldman Sachs23 min
Darren Star: From "Sex and the City" to "Younger": Coming of Age on Television
Speaker Aaron established a transformative television legacy by creating *90210*, *Melrose Place*, and *Sex and the City*, which collectively shifted network standards to embrace serialized storytelling, diverse representation, and female-centric narratives. His production strategy consistently prioritized controversial content and "found families" to challenge industry norms, directly influencing the cultural landscape and forcing *90210* to evolve from an issue-of-the-week format into a character-driven soap opera. Currently, he applies these foundational principles to *Younger*, leveraging streaming platforms to craft bingeable content that explores generational divides and encourages creative risk-taking in the modern media environment.
- Milken Institute1h 2m
Global Capital Markets
Gerard Baker, Mary Callahan Erdoes, Michael Corbat, Joshua Friedman, Scott Minerd, Ning Tang
Prominent financial leaders from Guggenheim, J.P. Morgan Asset Management, and Citigroup convened to analyze a 2018 global economy characterized by synchronous growth amidst rising debt levels, regulatory shifts, and structural market vulnerabilities. Key speakers warned that the rapid transition from quantitative easing to tightening, combined with the dominance of passive investing and record corporate leverage, creates significant risks for volatility and liquidity disruptions in coming years. The discussion further highlighted that while geopolitical tensions and trade deficits remain contentious, the most immediate threats to stability stem from a "fast speed, slow speed" trading dynamic and a labor market nearing critical constraints.