Latest Interviews
Showing 1246–1260 of 1,573 transcripts.
Clear all filters- The Economist24 min
Covid-19: why vaccine mistrust is growing
Professor Jonathan Heaney, Professor Heidi Larson, Dr Jonathan Kennedy, Kristin Urquiza, Neil Johnson, Fadi Kouran, Slavia Chankova
With over 20 COVID-19 vaccine candidates in development, experts warn that failing to achieve 70% population uptake due to widespread hesitancy could necessitate indefinite social restrictions. This crisis of trust is driven by political polarization, the legacy of the retracted Andrew Wakefield study, and algorithmic amplification of misinformation on social media platforms that have disproportionately spread falsehoods from figures like President Trump. In response, health organizations and tech-savvy clinics are launching counter-misinformation campaigns to protect herd immunity goals against hostile narratives that link political populism with declining public confidence.
- Jane Street45 min
Clock Synchronization with Chris Perl
Responding to MIFID 2 regulations, Jane Street engineered a hybrid time synchronization system that combines GPS-driven Precision Time Protocol with Linux-based NTP Interleaved Mode to achieve sub-100-microsecond accuracy across its infrastructure. By leveraging hardware timestamping at the network interface and cross-verifying local and distant time sources, the architecture mitigates standard PTP vulnerabilities while maintaining a simple, inspectable network topology. This design successfully reduces worst-case synchronization errors to approximately 35 microseconds, effectively balancing regulatory compliance with robust fault tolerance.
- a16z29 min
"Crypto Startup School" Documentary
Jeff, Teddy, Andrey Anisimov, Tina, Tope, Sarah Reynolds, Meta Katari
Andreessen Horowitz's Crypto Startup School launched a remote cohort of diverse founders to build decentralized finance applications like AfriX and HoneyLemon while navigating a 40% market crash and pandemic lockdowns. Through intensive collaboration and rigorous security audits, the teams overcame technical design errors to ship audited prototypes and secure early traction despite significant fundraising hurdles. The program successfully transitioned these entrepreneurs from ideation to Mainnet deployment, validating their models in a volatile environment while forecasting a future where cryptocurrency integrates as deeply as the internet into daily life.
- Goldman Sachs22 min
Ric Lewis, Executive Chairman of Tristan Capital Partners
Tristan Capital Partners Managing Director Rick Lewis outlines the firm's strategic navigation of the 2008 financial crisis and the 2020 pandemic, highlighting a distinct sector divergence where residential assets rebounded while office demand remains complex despite long-term recovery forecasts. Leveraging these insights, Lewis launched the Impact X Fund to provide growth capital for underrepresented entrepreneurs and restructured his foundation's philanthropy to target 85% BAME scholars, effectively shifting from silent leadership to active advocacy for social mobility. Beyond market analysis, the discussion emphasizes a philosophical call to action for high-performing individuals to prioritize tangible community investment and daily behavioral change over mere awareness to dismantle systemic barriers in both the UK and US.
- The Economist24 min
How to tackle corruption
Avril Andrews, Leslie Weingard, Shamila Bhattoyi, Max Nefudov, Cynthia Agnes Soraya Stimple
This event examines the global $3 trillion cost of corruption through critical case studies in South Africa, Ukraine, and the UK, highlighting specific outcomes such as South Africa's Zondo Commission, Ukraine's ProZorro digital transparency system, and the UK's AI-driven Rolls-Royce prosecution. It details high-level leadership efforts to restore integrity, including President Ramaphosa's restructuring of state institutions and the appointment of Shamila Bhattoo to lead the National Prosecuting Authority, while contrasting these with the systemic impunity that often penalizes whistleblowers like Cynthia Stimpell. Ultimately, the discussion underscores that sustainable anti-corruption requires a cultural shift toward protecting whistleblowers and replacing box-ticking compliance with genuine ethical accountability supported by technological innovation.
- a16z34 min
From Unknown Title to Viral Game: 12 Growth Lessons From Spellbreak
Proletariat leveraged a high-risk, community-first strategy to grow *Spellbreak* from a 2018 pre-alpha concept to over 1.8 million sign-ups by prioritizing viral social channels like Imgur and Discord over traditional owned media. The studio built momentum through an exclusive NDA-gated ecosystem that utilized referral incentives, mandatory voice chat for social bonding, and a "cool kids club" dynamic to drive organic acquisition and retention without monetary rewards. This approach generated millions in free marketing value and a highly engaged global base, positioning the free-to-play Battle Royale for a cross-platform launch while acknowledging that the initial success relied heavily on executing authentic content cadence to overcome the studio's lack of initial brand traction.
- Dwarkesh Patel35 min
Matjaž Leonardis - Science, Identity and Probability
Matjaž Leonardis, David Deutsch
Machos Leonardis critiques the restrictive social identity of "scientist" while co-authoring a re-examination of the Popper-Miller theorem that challenges the foundations of Bayesian reasoning in AGI development. The discussion further explores how universal explanatory theories drive human knowledge accumulation and offers polymath aspirants advice to prioritize curiosity-driven collaboration over systematic linear study. The episode concludes with host Dwarkesh Patel announcing upcoming content featuring Robin Hanson and acknowledging specific equipment donations.
- Goldman Sachs24 min
Mayors LaToya Cantrell, Eric Johnson, and Nan Whaley
LaToya Cantrell, Eric Johnson, Nan Whaley
Dallas, New Orleans, and Dayton mayors jointly addressed the compounding crises of the pandemic and civil unrest, implementing specific lockdowns, dual disaster declarations, and targeted equity initiatives to protect vulnerable populations. Each city deployed distinct economic recovery strategies, including Dallas's $15 million small business fund, New Orleans's French Quarter re-envisioning, and Dayton's focus on minority-owned enterprises, while collectively advocating for critical federal financial support. The leaders emphasized that these disruptions present a unique opportunity to enact systemic reforms and rebuild their municipalities with greater resilience and social justice in mind.
- Milken Institute33 min
A Conversation with Federal Reserve Bank of St. Louis President and CEO James Bullard
St. Louis Fed President James Bullard explains that the U.S. economy is adapting to pandemic risks through endogenous behavioral changes rather than broad lockdowns, projecting output recovery to 90% of normal levels despite historical quarterly declines. Bullard contrasts his view of a new steady state with host Josh Barrow's concern over permanently lower living standards, while addressing the dual policy challenge of balancing business preservation with market dynamism. Furthermore, Bullard highlights the strategic necessity of preventing a secondary financial crisis and identifies eliminating racial unemployment gaps as a critical metric for ideal monetary policy outcomes.
- Goldman Sachs27 min
Paul Farmer CBE, CEO of Mind
Experts and organizations including Mind, Samaritans, and Goldman Sachs are addressing a pandemic-induced surge in mental health crises by promoting protective strategies such as strict routine maintenance, digital detoxification, and structured remote work environments. Historical precedents from the SARS outbreak and 2008 economic crash inform current protocols for vulnerable demographics, including frontline workers facing PTSD risks and students navigating educational uncertainty. Ultimately, the initiative aims to leverage these challenges to normalize mental health care as a societal priority and institutionalize resilience-building practices for the next decade.
- Goldman Sachs44 min
Adm. Timothy J. Keating, USN (Ret.) and Brig. Gen. Robert S. Spalding III, USAF (Ret.)
Timothy J. Keating, Robert S. Spalding III, Admiral Timothy Keating, Brigadier General Robert S. Spalding III, Norman Nye, Tim Keating, Rob Spalding
Hosted by Goldman Sachs's Norman Nye on April 15, 2020, Admiral Timothy Keating and Brigadier General Rob Spalding assessed how the COVID-19 pandemic accelerated U.S.-China geopolitical rivalry, particularly regarding Taiwan, supply chain decoupling, and 5G surveillance infrastructure. The experts concluded that the crisis would permanently shift global alignment toward a "democratic bloc" prioritizing national security over economic integration, forcing a reshoring of critical industries and tighter restrictions on Chinese technology. They further warned that economic strains could provoke China to employ gray zone tactics while the United States pivots toward strengthening alliances in the Indo-Pacific, India, and Latin America.
- Goldman Sachs24 min
Rahm Emanuel, Former Chicago Mayor and Author of "The Nation City"
Political leader Rahm Emanuel argues that global power has permanently shifted from dysfunctional national institutions to local governments, where 75% public confidence drives mayors to assume federal responsibilities in climate action, education, and economic growth. Citing Chicago's transformation of its school system and energy grid, Emanuel demonstrates how local leadership can achieve measurable outcomes, such as raising high school graduation rates from 56% to nearly 80%, while overcoming federal gridlock. He asserts that this structural realignment is irreversible and calls for a political strategy focused on execution and enabling policy rather than broad, unfulfillable campaign promises.
- Milken Institute34 min
A Conversation with Strive Masiyiwa and Michael Milken
Strive Masiyiwa, Michael Milken
With Africa's population projected to reach 4 billion by 2100 and 12 million young entrants joining the workforce annually, the continent faces a critical imperative to modernize its fragmented economy and address high unemployment rates like the 29% in South Africa. Global tech giants and investors are capitalizing on unique innovations such as mobile money and blockchain to unify 54 currencies, while infrastructure projects connect the continent from Cape Town to Cairo alongside rapid 5G deployment. Strategic partnerships led by figures like Strive Maseiwa aim to train government leaders and expand private enterprise networks, positioning Africa as a primary future market despite capital shortages and the need to replace nearly 500 million traditional jobs.
- Milken Institute29 min
Mic'd Up - Part 2:Genomics & the Future of Medicine
Rick Berke, Phil Febbo, Anamika Mehta, Rakesh Suri
The event details how advanced viral defense mechanisms, culturally attuned facility designs, and rapidly declining genomic sequencing costs are reshaping clinical precision medicine, with specific case studies highlighting Cleveland Clinic Abu Dhabi's successful integration of these technologies. Key speakers analyze the friction caused by fragmented U.S. payers and electronic health records while contrasting these challenges with the streamlined adoption seen in the UK and the UAE's population-specific cancer initiatives. The discussion concludes with a strategic roadmap for the next decade that emphasizes decentralized care, robust data privacy protocols, and AI-driven analytics to transform genomic insights into actionable, personalized patient outcomes.
- Milken Institute25 min
Mic'd Up - Part 1: Public Health Response to Coronavirus
This expert panel discusses the emerging COVID-19 outbreak, noting its official WHO naming to prevent stigmatization, approximately 45,000 confirmed cases primarily in China, and the critical lack of international access due to data transparency concerns. Speakers analyze divergent future scenarios ranging from endemic circulation to a global pandemic with a 2% fatality rate, while critiquing delayed WHO leadership and insufficient vaccine development timelines that may exceed a year. The discussion further addresses necessary public health strategies, including social distancing over universal masking, the economic risks of draconian travel restrictions, and the urgent need for rapid diagnostic deployment amid funding cycles that previously hampered preparedness.