Latest Interviews

Public Debt: how much is too much?

Ryan Avent

Between April and June 2020, the United States borrowed a record $3 trillion while the global economy saw public debt surge by an estimated $300 billion due to pandemic-related spending. Historical precedents and favorable conditions, such as low interest rates, have traditionally allowed nations to sustain high debt levels, though experts warn that a potential rise in rates could threaten financial stability. Consequently, economists maintain that despite these risks, continued deficit spending remains essential to prevent lasting damage to the global recovery.

Covid-19: why travel will never be the same

Leo Mirani

In April 2020, global aviation experienced a historic collapse with passenger numbers dropping 94% year-over-year, forcing carriers like Virgin Atlantic to eliminate thousands of jobs while the IATA warned that without government aid, only 30 of over 700 airlines would survive. Regional recovery remains uneven, with European and U.S. flight levels still down by 75% and 57% respectively, threatening to permanently erase business travel segments that once subsidized leisure fares. Looking ahead, the industry faces a potential shift toward closed borders and reduced globalization, as travel restrictions and the retirement of older aircraft reshape the economic and operational landscape for years to come.

Covid-19: is working from home really the new normal?

Philip Coggan

The pandemic has accelerated a fundamental shift in the US labor market, transforming the remote work ratio from one in fifty to over one in three while forcing a reevaluation of the $10,000 annual cost per employee associated with traditional office leases. Tech leaders like Twitter and Facebook are institutionalizing permanent remote mandates, driving a transition from time-based industrial wages to function-based compensation even as urban productivity models face disruption from reduced office density and gendered employment impacts. Despite skepticism about replicating corporate culture and creativity online, future office spaces are expected to evolve from daily workstations into collaborative hubs that complement a decentralized, knowledge-based economy where remote eligibility remains highly variable across global regions.

Covid-19: what’s really going on in Russia?

Arkady Ostrovsky

Russian healthcare professionals have compiled unofficial records revealing that the nation's reported pandemic death rates are significantly lower than reality, prompting local officials in Dagestan and Moscow to later admit to severe undercounting to maintain an illusion of control. Amidst this crisis, President Vladimir Putin avoided a strict nationwide lockdown and faced plummeting popularity, yet he proceeded with a military parade and scheduled a constitutional vote to secure his grip on power until the end of his life. Analysts warn that instead of adopting transparency to address the pandemic's human toll, the leadership is likely to deepen repression, creating a dangerous precedent for a potentially violent future transfer of authority.

How scientists calculate climate change

Vilhelm Bjerknes, Oliver Morton

Building on Wilhelm Bjerknes' 19th-century formulas, modern atmospheric computers now operate 25 trillion times faster than early models to simulate global climate behavior through complex grid systems. Although technical limitations regarding small-scale cloud dynamics create divergent warming projections, historical data confirms these tools accurately forecast observed trends when paired with economic scenarios that link human policy to temperature outcomes. Ultimately, while these models cannot predict human decisions, they remain the essential instrument for quantifying carbon dioxide's impact and guiding the stringent emission reductions necessary to meet Paris Agreement targets.

Covid-19: how bad will it be for the economy?

Philip Coggan

Global markets have plummeted due to the pandemic-induced collapse of commodity prices and a historic surge in unemployment, triggering the fastest bear market decline on record as investors rapidly devalued future profit projections. Governments worldwide have deployed over $2.2 trillion in fiscal relief to balance economic survival against strict lockdowns that aim to prevent a spike in mortality rates, even though models warn that prolonged restrictions could slash U.S. and Eurozone GDP by one-third. While early indicators from China suggest a V-shaped recovery is possible, economists caution that restoring global supply chains and achieving economic stability will require a slow, cautious approach as nations navigate the trade-off between public health and financial contraction.

The new coronavirus: how should the world respond?

As the global pandemic escalated to 565 deaths and triggered market panic in mid-March, governments enforced unprecedented lockdowns while grappling with a stark trade-off between life-saving suppression and severe economic collapse. Analysis of China's strategy and modeling by Imperial College London demonstrated that only sustained social distancing could prevent critical care from exceeding capacity, though economic indicators like China's 20% retail decline signaled the high cost of such measures. Meanwhile, contrasting successes in Singapore and South Korea highlighted the necessity of aggressive testing and clear communication, even as experts warned that effective antibody testing and vaccines remain months away from resolution.

America v China: why the trade war won't end soon

Soumaya Keynes, Deng Xiaoping, Trump, David Rennie, Chad Bowne, Samaya

After sixteen months of reciprocal tariffs triggered by US concerns over China's rapid economic ascent and alleged unfair trade practices, the conflict has escalated to impose 25% duties on billions of dollars in goods while specifically targeting the agricultural sector to influence political outcomes. The dispute has severely impacted global growth projections and business investment, with recent restrictions on tech firm Huawei and a stalled "phase one" deal highlighting the deep structural disagreements regarding intellectual property and market access. Analysts caution that while a limited agreement might offer temporary tariff relief, the fundamental clash over US dominance in future industries and China's state-led economic model suggests a prolonged stalemate without comprehensive resolution.

Is America right to fear Huawei?

Ren Zhengfei, Joe Franell

Amidst a geopolitical clash where the US government labels Huawei a national security risk citing China's 2017 National Intelligence Law, the world's largest telecommunications manufacturer faces a 2019 ban on American components despite offering independent code audits. While Huawei's founder Ren Zhengfei acknowledges the resulting uncertainty, the company's cheaper 5G infrastructure remains critical for billions of users globally, including rural US networks. Analysts warn that excluding Huawei could fracture global supply chains and stall technological progress, yet the US administration maintains its stance to counter China's strategic rise in the telecommunications sector.

Reducing the Cost and Risk of Dementia

Nora Super, Michael Belleville, Jennie Chin Hansen, Kevin Crain, Jeff Huber, Shari Ling, Sarah Locke, Ian Cramer, Orion, Alan Stevens, Jill Lesser

The Milken Institute's new report on reducing dementia costs sparked a multi-sector dialogue involving CMS officials, patient advocates, and industry leaders to address critical gaps in workforce preparedness and community support. Key initiatives highlighted include CMS's expanded billing codes for cognitive screening, the rapid growth of accredited Geriatric Emergency Departments that reduce hospitalizations, and innovative financial strategies to protect caregivers from retirement disparities. Panelists emphasized that effective intervention requires moving beyond isolated medical treatment to holistic models that integrate home care, fraud detection, and policy changes aimed at improving long-term quality of life.

How Brexit is changing the EU

Andrea Venson, Marine Le Pen

Following the 2016 Brexit referendum, which initially predicted the European Union's dissolution, public attachment to the bloc has strengthened and populist exit movements have largely subsided as leaders like Marine Le Pen shifted toward reforming the EU from within. This resilience was demonstrated through the bloc's successful navigation of the 2008 financial crisis and 2015 migrant surge, fostering a paradoxical sentiment where the departure of the UK is viewed as a stabilizing force rather than a catalyst for fragmentation. Consequently, while exit sentiment remains significant in specific nations like Italy, the overall trend reveals a political will among diverse member states to preserve the union against threats, exemplified by the rise of pan-European movements such as Volt Europa.

CRISPR 2.0 and the Future of Gene Therapies

Andy Tran

The gene therapy sector is undergoing a paradigm shift from simple transgene addition to precise CRISPR-based editing, driven by recent FDA approvals and a pipeline projecting dozens of Phase 3 trials this year. Despite significant progress in developing base editors and expanding delivery vectors, the industry faces critical bottlenecks in manufacturing scalability and achieving organ-specific targeting without immunogenicity. Successful organizations are distinguishing themselves by combining rigorous engineering mindsets with interdisciplinary teams to optimize modalities and automate production for a future of millions of patients.

Carolynn Levy - Modern Startup Funding

Carolynn Levy

Early-stage financing has shifted from complex, costly Series A preferred stock rounds to streamlined convertible securities like Y Combinator's SAFE, which allow founders to raise capital rapidly without immediate legal counsel. While these instruments facilitate frequent small checks and faster closings, they introduce challenges such as tracking dilution until conversion and potential administrative burdens from party rounds with numerous angels. Ultimately, founders must balance the efficiency of modern templates against specific deal structures and regional investor preferences to avoid corner cases where funding fails to convert into equity.

Can You Apply to YC Before You Have a US Visa? - Jared Friedman

Jared Friedman

Y Combinator actively admits non-U.S. citizens and provides specific assistance to secure B-1 business visas, which serve as the standard solution for the program's three-to-four-month duration. Historical data confirms that founders lacking U.S. citizenship or existing visas face virtually no barriers to admission, despite their foreign status. Consequently, international entrepreneurs are encouraged to proceed with applications without concern regarding visa eligibility for participation.

Request for Startups: Government 2.0 - Michael Seibel

Michael Seibel

Y Combinator CEO Michael Seibel has launched a "Request for Startups" initiative titled "Government 2.0" to identify for-profit ventures using software to solve societal failures that traditional government entities have not resolved. The program specifically targets founders motivated by social impact over mere wealth or scale, aiming to validate Silicon Valley's capacity to drive meaningful community improvements. This effort builds on historical YC successes in sectors like healthcare and criminal justice to demonstrate investor enthusiasm for startups with significant missions.