Latest Interviews
Showing 616–630 of 9,624 transcripts.
Clear all filters- Milken Institute57 min
Rewriting the Rules: Scaling Innovation for Rare Diseases | Global Conference 2026
Becky Quick, Nicola Blackwood, David Fajgenbaum, Michael Hund, Neil Kumar, William H. Lewis
Panelists including David, Will Osborn, and Michael discussed how AI-driven repurposing of generic drugs and patient-led "venture cure" models are accelerating the discovery of treatments for the over 300 million people globally affected by rare diseases. The dialogue highlighted transformative regulatory shifts, such as the UK's newborn sequencing trials and FDA-authorized umbrella CRISPR studies, which aim to bypass traditional trial inefficiencies while addressing barriers like pricing models that stifle global drug launches. Ultimately, the event concluded that converging data infrastructure with proactive patient advocacy is essential to de-risk development and deliver rapid therapeutic interventions for currently untreatable conditions.
- Jane Street1h 34m
Building a Data Warehouse From Scratch with Jacob Baskin
Jacob Baskin's career spans mechanism design research at Brown, building real-time ad exchanges at Google, and attempting to digitize urban parking infrastructure. At Jane Street, he engineered the SuperStore distributed database to replace legacy monoliths and designed the auction-based resource allocation system for the massive Hive compute cluster. His current work focuses on refining these mechanisms by addressing utility gaps in bidding models and implementing scalable data distribution architectures to support large-scale machine learning and simulation tasks.
- Sequoia Capital45 min
Memory and Continual Learning: Engram's Dan Biderman and Jessy Lin
Dan Biderman, Jessy Lin, Sonya Huang, Shaun Maguire
Ngram addresses the scalability and cognitive limitations of current retrieval-augmented generation by training custom, continually learning models directly within workspace environments. This approach utilizes adapter fine-tuning to internalize organizational knowledge into model weights, reducing inference token consumption by a factor of 100 while enabling true intuition rather than static fact retrieval. By shifting the focus from pre-training generic AI to perpetual, private adaptation, the platform aims to create personalized neural interfaces that evolve alongside a team's data.
- Stanford Online49 min
Stanford MS&E435 Economics of the AI Supercycle | Spring 2026 | Applications, Coding AI
Guillermo Rauch, Apoorv Agrawal
Vercel, a $9.3 billion infrastructure firm founded by Guillermo Rauch, is pivoting its business model from standard web pages to "agentic infrastructure" to support the exponential growth of AI coding agents and token-based consumption. The company leverages a full-stack approach anchored in open source frameworks like Next.js, enabling enterprises such as Meta and Notion to deploy self-driving cloud capabilities that automate software configuration and security. This strategic shift, which has driven a threefold growth rate since October 2024, positions Vercel as the dominant platform for high-velocity, agent-generated code while redefining industry pricing and deployment standards.
- All-In Podcast1h 3m
GameStop CEO Ryan Cohen’s $56B Plan to Take Over eBay
After restructuring GameStop by cutting costs and capitalizing on the collectibles market to generate $9.7 billion in cash, Ryan Cohen proposed a $56 billion acquisition of eBay to merge its physical store network with digital scale. The eBay board rejected this offer citing execution risks and financing uncertainties, prompting Cohen to threaten a hostile campaign involving tender offers to force shareholder value. This confrontation highlights Cohen's strategy of leveraging physical retail for live commerce and digital assets while contrasting his personal financial risk against entrenched eBay management.
- Bank of America21 min
America at 250 – Innovation, Market Leadership and the Power of Compounding
Presented on June 16, 2026, this analysis details the United States' 150-year economic dominance, driven by superior corporate earnings growth, a $1 trillion annual R&D investment, and the dollar's enduring role as the primary global reserve currency. The report challenges the traditional 60-40 portfolio strategy by demonstrating the historical lack of consistent negative correlation between U.S. equities and long-term Treasury bonds, which have often moved in tandem during recent market cycles. Ultimately, the discussion underscores structural advantages in governance and innovation efficiency that sustain U.S. outperformance despite the current challenges posed by an overvalued currency and global reindustrialization trends.
- Goldman Sachs10 min
What the IPO Boom Means for the US Equity Outlook
The U.S. IPO market has surged to its highest first-half volume since 2021 with nearly 50 deals totaling $120 billion, driven by capital demands for the artificial intelligence sector and a return of large corporations to the public market. While the Goldman Sachs IPO Barometer signals strong sentiment above its long-term average, the current environment remains distinct from historical bubbles as equity valuations stay below peaks seen in 2000 and 2021. Analysts project a continued bull trend for the S&P 500 through 2027, though they warn of potential volatility emerging as investor leverage rises and IPO lockup periods eventually expire.
Mark Pincus: How to Spot a Fake CEO
Mark Pincus launches his book *Life at the Speed of Play* to distill four years of entrepreneurial experience into a framework that distinguishes enduring instincts from temporary ideas. The work integrates case studies from Zynga and Tribe.net to advocate for "Proven Better New" product strategies while challenging leaders to prioritize product execution over consensus. Pincus concludes with bullish predictions on AI market consolidation and a call for founders to maintain "Founder Mode" by constantly adapting tactics despite a stable vision.
- Milken Institute1h 0m
The New Macro Playbook | Global Conference 2026
Stephanie Ruhle, André Esteves, George Goncalves, Karen Karniol-Tambour, Seema Shah, Jeffrey Solomon
Global capital flows are shifting from a U.S.-centric model to diversified inflows in emerging markets and resource economies, driven by a transition from efficiency-based globalization to sovereign security-focused supply chains. This structural change, characterized by modern mercantilism and massive AI infrastructure spending, has created a bifurcated economy where fiscal deficits and geopolitical fragmentation fuel persistent inflation while prompting investors to seek physical assets over traditional equities. As nations fragment into isolated economic blocks and governments face rising risks of financial repression, investors must navigate these divergent currency zones to identify opportunities in captive markets protected by national industrial policies.
- Bank of America27 min
Task force hawkish
Mark Cabana, Aditya Bave, Stephen, Alex Cohen
In a unanimous June vote marking the fourth Federal Reserve chair transition in nearly four decades, policymakers shortened their official statement to omit labor market goals and dissolved transparency norms regarding dissents while establishing five task forces to review internal frameworks. The updated economic projections revealed a sharp hawkish split with nine of eighteen participants forecasting rate hikes this year, driving a consensus that current monetary policy remains insufficient to curb elevated inflation despite supply shocks. This shift in tone and data interpretation triggered an immediate dollar appreciation and led market strategists to adjust positions toward front-end rates and flatteners in anticipation of policy-induced volatility.
- Goldman Sachs20 min
Thelma Golden on Preserving Black Culture and the New Era of the Studio Museum in Harlem
Thelma Golden, serving as Ford Foundation Director and Chief Curator of the Studio Museum in Harlem, continues her career-long mission to center artists of African descent while overseeing the museum's relocation into a new state-of-the-art facility in November. Her leadership leverages strategic partnerships with entities like Goldman Sachs to transform the institution from a temporary loft into a permanent cultural anchor that preserves the legacy of the 1968 founding while supporting contemporary creation. This expansion aims to solidify the museum's role as a vital space where art functions as both a historical mirror and a visionary window for processing current societal realities.
- Y Combinator14 min
How to Get Your First 10 Customers
This guide outlines a tactical framework for founders to secure their first ten customers by prioritizing manual, high-trust interactions over scalable automation. Early acquisition focuses exclusively on personal networks and in-person efforts, utilizing specific channels like micro-events, targeted Reddit DMs, and value-driven advice requests before ever deploying prospecting tools. Once these foundational deals are won through unscalable work, the strategy shifts to utilizing software like Apollo and Clay to replicate the validated pitch for subsequent growth.
- a16z1h 4m
Jake Paul on Going From YouTube to Boxing to Investing | a16z ft. Anti Fund
Antifun has launched a fully over-subscribed $100 million growth fund to leverage Jake Paul's cultural influence alongside traditional venture capital resources, targeting tier-one AI and tech entities like OpenAI and SpaceX. This partnership merges Paul's experience as a resilient "tastemaker" who successfully pivoted from YouTube to professional boxing with strategic insights from industry veterans, focusing on founders who combine high pain tolerance with exceptional attention-wielding capabilities. Together, the collaborators aim to incubate new companies while championing a future where human value is defined by a dual focus on technical "AI maxing" and charismatic "looks maxing" in an increasingly automated landscape.
Nikesh Arora on the Frontier Model Problem: Breadth vs Depth | The Future of Token Costs
Palo Alto Networks CEO Nikesh Arora outlines a strategic vision where enterprise AI evolves from mere augmentation to agentic judgment, fundamentally reimagining workflows and driving a predicted 50% reduction in administrative headcount. Addressing the cybersecurity landscape, Arora explains how frontier models like "Mythos" accelerate vulnerability discovery while necessitating a shift toward unified, AI-infused gateways to manage autonomous agent traffic. Complementing this technical roadmap, his investment philosophy advocates for early engagement in unproven technologies and warns against current market euphoria, predicting a tenfold drop in token costs that will force a realignment of model valuations based on actual developer utility.
- The Diary Of A CEO1h 48m
Dr Rachel Rubin: "I'm Filled With Rage!" Your Doctor Was Never Taught About Women's Bodies!
A comprehensive review highlights critical gaps in women's sexual health, noting that over 75% of eligible patients lack access to generic hormone therapies while medical training omits essential anatomy like the clitoris. The discussion addresses how factors ranging from birth control suppression to GLP-1 medication side effects exacerbate sexual dysfunction, despite evidence that micro-dosed vaginal hormones and systemic testosterone are safe and effective for diverse populations. Ultimately, the event outlines a strategy to educate providers and patients on responsive arousal and specialized pelvic care to reverse the current trend where only 1.7% of eligible women receive necessary treatments.